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Objective: To evaluate the analgesic effect of pregabalin combined with intrathecal sufentanil infusion for the treatment of breakthrough pain in patients with bone metastases. Methods: A total of 60 breakthrough pain patients with bone metastases were randomly divided to 3 groups: group A (pregabalin combined with intrathecal sufentanil infusion group,n=20), group B (placebo combined with intrathecal sufentanil infusion group,n=20) and group C (oral morphine sulfate controlled-release tablet group,n=20). The differences in visual analogue scale (VAS)between background pain and breakthrough pain, the seizure frequency of breakthrough pain, general satisfaction and side effects of the 3 groups were observed. Results: hTe seizure frequency and VAS of breakthrough pain in group A decreased signiifcantly after the treatment (P<0.05) and the general satisfaction was the best among the the 3 groups (P<0.05), with less nausea and vomiting, constipation, drowsiness and fewer other side effects. Conclusion: Pregabalin combined with intrathecal sufentanil infusion can effectively relieve breakthrough pain in patients with bone metastases.
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0.05).There was significantly increased HR,SBP,DBP after implantated the suspensive laryngoscopy in group Ⅰ(P
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0.05).The blood sugar of group B was significantly higher after gastroscope insertion,There was significant difference between pre-insertion and post-insertion(P
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Objective To evaluate the effect of three anesthetic methods on induced abortion. Methods three hundred women were randomly divided into three groups, groupⅠ(n=100), intravenous injection propofol(1.0~1.5mg/kg),groupⅡ(n=100),intravenous injection propofol (1.0~1.5mg/kg)combined with fentanyl ( 1?g/kg),group Ⅲ(n=100),2%lidocaine(5ml) into cavity of uterus as control group. Analgesia efficacy was assessed by visual analog scales (VAS) and sedation scales,SBP,DBP,SpO_2 at all in three groups.Results Analgesia efficacy in group Ⅱ was obviously higher than that in group Ⅰ(P