ABSTRACT
Serum samples (n: 110) from blood donors and high risk individuals from Cordoba, Argentina with indeterminate HIV-1 and HTLV-I/II Wb profiles were studied for specific antibodies to HTLV-I/II and HIV-1 by indirect immunofluorescence assay (IFA) and for the presence or absence of HIV-1 and HTLV-I/II specific bands by Wb. This study was carried out in order to characterize their putative reactions with HIV-1 and HTLV-I/II proteins and to resolve the retrovirus infection status of these individuals. Results indicated that blood donors sera displaying indeterminate HIV-1 or HTLV-I/II Wb patterns were not immunoreactive to HTLV-I/II and HIV-1 on IFA. However, a high rate of indeterminate HIV-1 and HTLV-I/II Wb samples from high risk individuals had positive HTLV-I/II and HIV-1 IFA results respectively. Our study supports the growing evidence that HTLV-HIV indeterminate seroreactivity in low risk population is due to a cross reaction against nonviral antigens, and in high risk populations the indeterminate samples show serological cross-recognition between HIV-1 proteins and HTLV-I/II proteins on Wb. These results point out the necessity to investigate the HTLV-I/II reactivity in indeterminate HIV-1 samples and viceversa in order to confirm the diagnosis. Finally, this study shows the potential usefulness of IFA in elucidating the status of HIV-1 and HTLV-I/II infection of individuals with indeterminate Wb profiles, thus enabling resolution of retrovirus infection status
Subject(s)
Humans , Male , Female , Blotting, Western , Deltaretrovirus Antibodies , Fluorescent Antibody Technique, Indirect , Retroviridae Infections , Argentina , Blood Donors , Cross Reactions , False Negative Reactions , HIV Antibodies , HIV Infections , HTLV-I Antibodies , HTLV-I Infections , HTLV-II Antibodies , HTLV-II Infections , Retroviridae Infections , Risk FactorsABSTRACT
1) Se presenta el primer caso registrado en nuestra ciudad de Kaposi por SIDA, describiendo sus síntomas y evolución. 2) El paciente era un hombre, heterosexual, no drogadicto pero vinculado a drogadictas, de 37 años de edad. 3) Manifestaba vida sexual muy activa y promiscua. Había padecido numerosos procesos venéreos. Bebedor. 4) A pesar de su aparente estado general relativamente conservado en junio de 1987, y control especiazado, el paciente fallece ocho meses después de diagnosticado el proceso