Ultrasound measurement of thyroid volume in euthyroid children under 3 years of age / Mensuração ultrassonográfica do volume tireoidiano em crianças eutireóideas menores de três anos

Abstract Objective: To establish ultrasound reference values for thyroid volumes in children up to 3 years of age, given that ultrasound of the thyroid is an essential examination in the diagnosis of childhood thyroid disease. Materials and Methods: This was a prospective study conducted in an iodine-sufficient city in southeastern Brazil. A total of 100 healthy children underwent clinical evaluation, anthropometric examination, and cervical ultrasound in accordance with conventional protocols. We evaluated characteristics such as echotexture, thyroid lobe volume, and total thyroid volume. The children were divided into five groups, by age: < 2 months; 2-12 months; 12-18 months; 18-24 months; and 24-36 months. Results: The mean thyroid volume was lower in the < 2 month age group than in the other groups (0.4 mL vs. 0.18-0.70 mL; p < 0.001). For the subjects between 2 and 36 months of age, the mean volume was 1.0 mL (range, 0.30-2.0 mL). No other significant differences were observed between groups, thyroid lobes, or gender. However, body mass index correlated significantly with total thyroid volume (r = 0.347; p = 0.001). Conclusion: The mean thyroid dimensions were smallest in the < 2 month age group (0.35 ± 0.16 mL). For the subjects between 2 and 36 months of age, a reference value of 0.85 ± 0.42 mL can be used. Our data could guide the diagnostic investigation of thyroid disease, especially congenital hypothyroidism, in childhood.

Resumo Objetivo: Estabelecer valores de referência ultrassonográficos de volumes tireoidianos em crianças de até três anos de idade, por ser exame essencial no diagnóstico de doença tireoidiana infantil. Materiais e Métodos: Trata-se de estudo prospectivo conduzido em cidade do sudeste brasileiro suficiente em iodo. Participaram 100 crianças saudáveis, submetidas a exame clinicoantropométrico e ultrassonografia cervical seguindo protocolos convencionais. Características como ecotextura e volumes dos lobos e da tireoide total foram obtidos. Segundo a idade, as crianças foram distribuídas em cinco grupos: < 2 meses; 2-12 meses; 12-18 meses; 18-24 meses; e 24-36 meses. Resultados: No grupo < 2 meses os volumes tireoidianos foram menores (p < 0,001) do que nos demais (0,4 mL; 0,18-0,70 mL). Além dessa idade, o volume total médio foi 1,0 mL (0,30-2,0 mL) e não diferiu entre os grupos. Não foram observadas diferenças entre lobos ou relacionadas a gênero. Houve correlação (r = 0,347; p = 0,001) entre índice de massa corporal e volume total. Conclusão: As dimensões tireoidianas foram menores até dois meses (0,35 ± 0,16 mL), e a partir dessa idade os mesmos valores de referência podem ser usados até 36 meses (0,85 ± 0,42 mL). Tais dados podem orientar a investigação diagnóstica, especialmente no hipotireoidismo congênito.

Puberty in a sample of brazilian schoolboys: onset and anthropometric characteristics / Puberdade em uma amostra de meninos escolares brasileiros: início e características antropométricas

ABSTRACT Objective: To determine the age of puberty onset in boys and collect anthropometric data of participants at different puberty stages. Methods: This is a cross-sectional study that assessed 430 boys in a random sample representing 48,390 students from public and private schools from the city of Uberaba, Southeast Brazil. The inclusion criteria were males, aged between 5 and 18 years, and absence of previous diseases. Participants and their guardians filled a semistructured questionnaire with questions relevant to their and their parents' puberty. We set the significance at p<0.05 and calculated the 95% confidence intervals. Results: The mean age found in the puberty stage G2 was 11.2±1.8 (95% of participants in stage G2 were 9.2-13.4 years old). Pubarche data showed a mean of age of 11.0±1.6 years (95% of the participants experienced pubarche when they were 8.0-14.0 years old). When compared to the confidence intervals of two classical studies on the subject, our results showed a trend toward earlier pubarche. In addition, the mean age of this event in the children's parents was of 12.1±1.4 years, which was significantly higher than the age of the children's pubarche (p<0.001). Conclusions: These results indicate a secular decreasing trend in pubarche age and an earlier puberty onset. Considering these parameters, is important to design public policies aimed at preventing these early events.

RESUMO Objetivo: Determinar a idade em que a puberdade começa em meninos e coletar dados antropométricos de participantes em diferentes fases da puberdade. Métodos: Trata-se de um estudo transversal no qual foram avaliados 430 meninos, uma amostra aleatória representativa da população total de 48.390 estudantes de escolas públicas e particulares de Uberaba, Minas Gerais. Os critérios de inclusão foram: ser do sexo masculino, ter idade de 5 a 18 anos e ausência de doenças prévias. Os participantes e seus responsáveis preencheram um questionário semiestruturado com perguntas pertinentes à sua puberdade e à de seus pais. Os dados foram considerados significantes para p<0,05, e os intervalos de confiança calculados foram de 95%. Resultados: A média de idade encontrada no estágio G2 foi de 11,2±1,8 anos, sendo que 95% dos participantes em G2 tinham entre 9,2 a 13,4 anos. Quanto à pubarca, a média de idade foi de 11,0±1,6 anos, e 95% dos participantes apresentaram pubarca entre 8,0 e 14,0 anos. Quando tais resultados foram comparados aos intervalos de confiança de dois estudos clássicos sobre o tema, houve tendência à pubarca mais precoce. Além disso, a média de idade da pubarca nos pais das crianças foi de 12,1±1,4 anos, significantemente maior em relação à dos filhos (p<0,001). Conclusões: Os resultados indicam uma tendência secular em direção à diminuição da idade da pubarca e um possível início mais precoce da puberdade. É muito importante considerar esses parâmetros para estabelecer políticas públicas destinadas a prevenir esses eventos iniciais.

Effectiveness of screening for tuberculosis in HIV: a pragmatic clinical trial

ABSTRACT OBJECTIVE: To verify the effectiveness of screening for tuberculosis (TB) on all-cause mortality and tuberculosis cases in newly diagnosed HIV-infected patients through a clinical algorithm based on recommendations of the World Health Organization. METHODS: From March 2014 to April 2016, a pragmatic randomized clinical trial was conducted with newly diagnosed and TB-free HIV-infected adults undergoing antiretroviral therapy for up to one month at a major tertiary hospital for HIV in the state of Pernambuco, Brazil. Participants were randomized into intervention and control groups using an automatically-generated random list, and followed-up for at least 6 months. The intervention group was screened for TB at hospital admission and at every follow-up visit through a series of questions addressing TB-related symptoms (cough, fever, night sweating, and weight loss). Patients presenting with any of these symptoms were referred to a pulmonologist and underwent sputum smear microscopy, sputum culture, and rapid molecular testing (GeneXpert). When at least one test result came back positive, TB treatment was initiated. In turn, if patients tested negative but presented with severe clinal symptoms, TB preventive treatment was initiated. Screening for TB was not performed systematically in the control group. The primary outcome assessed in this study was death from all causes, and secondary outcomes included sensitivity and specificity of this screening test, as well as its detection time. RESULTS: This study evaluated 581 patients, 377 in the intervention group (64.9%) and 204 in the control group (35.1%). In total, 36 patients died during the follow-up period. Of these, 26 (6.9%) were from the intervention group, reaching a cumulative mortality coefficient of 69 per 1,000 inhabitants, and 10 (4.9%) from the control group (p = 0.341), with a cumulative mortality coefficient of 49 per 1,000 inhabitants (p = 0.341).

Clinical and laboratory parameters of gonadotropin-releasing hormone analog treatment effectiveness in children with precocious puberty

OBJECTIVE: There are no doubts about the clinical benefits of treatment with GnRH analogs for patients diagnosed with central precocious puberty (CPP). However, laboratory monitoring of CPP is still a matter of considerable controversy in the literature. Therefore, the main objective of this study was to evaluate the cut-off values of stimulated LH that determine gonadotrophic suppression. METHODS: Twenty-four girls, on treatment with leuprorelin acetate (LA) at 3.75 mg IM every 28 days, were studied. The clinical parameters used to indicate clinical effectiveness were regression or maintenance of sexual characteristics according to the Tanner stage, growth velocity reduction, reduction or maintenance of the difference between bone age and chronological age and maintenance or improvement of the final height prediction. For the laboratory effectiveness test, basal estradiol, LH, and FSH levels were collected before and 1 and 2 h after the administration of 3.75 mg LA. RESULTS: Eleven girls showed improvement in all clinical parameters, and their effectiveness tests were compared to those of the other patients to calculate the cut-off values, which were ≤3.64 IU/L (p=0.004*) for LH after 1 h and ≤6.10 IU/L (p<0.001*) for LH after 2 h. CONCLUSION: The LH response after the LA stimulation test, associated with clinical data and within a context of CPP, constitutes a reliable and feasible resource and can assist in monitoring the effectiveness of treatment.

Metabolic and hormonal assessment of adolescent and young adult women with prior premature adrenarche

OBJECTIVE: Follow-up studies of girls with premature adrenarche have reported the development of polycystic ovary syndrome, insulin resistance, and dyslipidemia and a propensity to cardiovascular disease. The aim of this study was to analyze the presence of these conditions in patients previously treated at the Universidade Federal do Triângulo Mineiro. METHODS: A total of 130 medical records reported premature adrenarche. One hundred and twenty-two patients were invited to participate, of whom 54 accepted; 34 patients were selected, as they had reached their final height. Anthropometric, blood glucose, insulin, and lipid and hormonal profile (LH, FSH, estradiol, 17α-OH-progesterone, androstenedione, dehydroepiandrosterone sulfate, testosterone) data were obtained, the HOMA-IR index was calculated, and pelvic ultrasonography was performed. To characterize polycystic ovary syndrome and metabolic syndrome, the Rotterdam and International Diabetes Federation criteria, respectively, were used. Data were analyzed according to measures of dispersion, frequency and correlations of interest. RESULTS: The age of the participants ranged from 15.2 to 28.2 years/months; 23.5% of the patients were overweight, 11.8% were obese, 29.4% had a large waist circumference, and 8.8% were hypertensive. None of the patients had altered glucose levels, and insulin levels and HOMA-IR were elevated in 29.4% and 38.2% of the participants, respectively; 14.7% of the patients exhibited acanthosis nigricans. The lipid profiles of the participants were variable, and one patient (2.9%) had metabolic syndrome. Polycystic ovary syndrome was found in 41.2% of patients. CONCLUSION: The percentage of patients with polycystic ovary syndrome who also had overweight, obesity and insulin resistance corroborates the literature data about the need for follow-up aiming at interventions, especially for conditions associated with cardiometabolic risk.

Associação entre acantose nigricans e outros fatores de risco cardiometabólico em crianças e adolescentes com sobrepeso e obesidade / Association between acanthosis nigricans and other cardiometabolic risk factors in children and adolescents with overweight and obesity

RESUMO Objetivo: Avaliar em um grupo de crianças e adolescentes com obesidade e sobrepeso a presença ou não de acantose nigricans e sua associação com alterações metabólicas. Métodos: Estudo transversal envolvendo 161 indivíduos com excesso de peso, que foram divididos em dois grupos, segundo a presença ou não de acantose nigricans, e nos quais foram obtidas medidas antropométricas (índice de massa corporal, pregas cutâneas, circunferência abdominal), pressão arterial, análises laboratoriais (glicemia de jejum, insulina, perfil lipídico, triglicerídeos, ácido úrico, transaminases) e o índice homeostasis model assessment. Resultados: O grupo com acantose nigricans representou 51,5% da amostra. A média de idade foi semelhante entre os grupos. O grupo com acantose nigricans apresentou maiores índice de massa corporal, escore Z do índice de massa corporal, percentual de gordura corporal, circunferência abdominal (p<0,0001) e pressão arterial sistólica (p=0,006) e diastólica (p=0,002). Não houve diferença significativa na análise do perfil lipídico, exceto o colesterol de alta densidade, que foi menor (p=0,003) no grupo com acantose. Já o ácido úrico (p<0,0001), a glicemia de jejum (p=0,006), a insulina (p<0,0001), a transaminase glutâmica oxalacética (p<0,0001) e o índice homeostasis model assessment (p<0,0001) foram significativamente maiores no grupo com acantose nigricans. Conclusões: Acantose nigricans em crianças e adolescentes com sobrepeso e obesidade esteve associada à elevação dos índices de adiposidade corporal, pressão arterial, insulina e homeostasis model assessment, indicando-a como marcador clínico associado à síndrome metabólica.

ABSTRACT Objective: To evaluate the presence or absence of acanthosis nigricans and its association with metabolic alterations in a group of obese and overweight children and adolescents. Methods: A cross sectional study of 161 overweight children and adolescents, who were divided into two groups, according to presence or absence of acanthosis nigricans. Anthropometric measurements (body mass index, skinfolds, abdominal circumference), blood pressure, laboratory tests (fasting glycemia, insulin, lipid profile, triglycerides, uric acid, transaminases) and homeostasis model assessment index. Results: The acanthosis nigricans group represented 51.5% of the sample. The mean age was similar between groups. The group with acanthosis nigricans presented higher body mass index, Z score of body mass index, body fat percentage, abdominal circumference (p<0.0001), systolic (p=0.006) and diastolic blood pressure (p=0.002). There was no significant difference in the analysis of lipid profile, except for the high-density cholesterol, which was lower (p=0.003) in the group with acanthosis. On the other hand, uric acid (p<0.0001), fasting glycemia (p=0.006), insulin (p<0.0001), glutamic oxalacetic transaminase (p<0.0001), and homeostasis model assessment index (p<0.0001) were significantly higher in the group with acanthosis nigricans. Conclusions: Acanthosis nigricans in overweight and obese children and adolescents is associated with elevation of body fat, blood pressure, insulin and homeostasis model assessment index, indicating that it is a clinical marker associated with the metabolic syndrome.

Interferência nutricional no tratamento de pacientes com diabetes mellitus tipo 1 / Interferencia nutricional en el tratamiento de pacientes con diabetes mellitus tipo 1 / Nutritional interference in the treatment of patients with diabetes mellitus type 1

RESUMO O tratamento do Diabetes Mellitus tipo 1 (DM1) constitui-se na adesão ao tratamento insulínico, na alimentação e na atividade física, visando ao controle glicêmico. O objetivo deste estudo foi observar os efeitos da interferência nutricional no tratamento de pacientes com DM1. Trata-se de estudo quantitativo, prospectivo e longitudinal desenvolvido no Ambulatório de Diabetes da UFTM. A coleta de dados foi realizada entre março de 2013 e setembro de 2014. Foram avaliados 41 crianças e adolescentes entre 6 e 17 anos, quanto à antropometria, controle glicêmico e lipídico em 4 momentos: M1 no início do seguimento; M2 após orientação nutricional convencional; M3 após aprendizagem da contagem de carboidratos (CCHO) e M4 em contagem plena. A análise estatística foi descritiva e inferencial. A antropometria comprovou que a CCHO não resultou em ganho de peso e foi efetiva no sexo masculino, demonstrada pela redução nas concentrações de frutosamina (p=0,050) e HbA1C (p=0,041) no M4 comparado ao M1. Considerando a frutosamina, o grupo com CCHO se diferenciou do grupo sem CCHO M4 (p=0,035). A terapêutica insulínica associada à CCHO demonstrou ser um recurso importante a ser integrado no tratamento do DM1, visando atingir alvos efetivos na redução das complicações.

RESUMEN El tratamiento de la Diabetes Mellitus tipo 1 (DM1) se constituye en la adhesión al tratamiento medicamentoso, en la alimentación y en la actividad física, centrando en el control glucémico. El objetivo de este estudio fue observar los efectos de la interferencia nutricional en el tratamiento de pacientes con DM1. Se trata de estudio cuantitativo, prospectivo y longitudinal desarrollado en el Ambulatorio de Diabetes de la UFTM (Universidade Federal do Triângulo Mineiro). La recolección de datos fue realizada entre marzo de 2013 y septiembre de 2014. Fueron evaluados 41 niños y adolescentes entre 6 y 17 años, en cuanto a la antropometría, control glucémico y lipídico en 4 momentos: M1 en el inicio del seguimiento; M2 tras orientación nutricional convencional; M3 tras aprendizaje del conteo de carbohidratos (CCHO) y M4 en conteo pleno. El análisis estadístico fue descriptivo e inferencial. La antropometría comprobó que el CCHO no resultó en ganancia de peso y fue efectivo en el sexo masculino, demostrado por la reducción en las concentraciones de fructosamina (p=0,050) y HbA1C (p=0,041) en el M4 comparado al M1. Considerando la fructosamina, el grupo con CCHO se diferenció del grupo sin CCHO M4 (p=0,035). La terapéutica insulínica asociada al CCHO demostró ser un recurso importante a ser integrado en el tratamiento del DM1, a fin de alcanzar blancos efectivos en la reducción de las complicaciones.

ABSTRACT The treatment of Diabetes Mellitus Type 1 (DM1) involves adherence to insulin treatment, diet and physical activity, aiming at glycemic control. The objective of this study was to observe the effects of nutritional interference in the treatment of patients with DM1. It is a quantitative, prospective and longitudinal study developed at the UFTM Diabetes Outpatient Clinic. Data collection was performed between March 2013 and September 2014. Thirty-one children and adolescents between 6 and 17 years old were evaluated for anthropometry, glycemic and lipid control in four stages: M1 at the beginning of follow-up; M2 after conventional nutritional counseling; M3 after learning the carbohydrate count (CCHO) and M4 in full count. Statistical analysis was descriptive and inferential. The anthropometry showed that CCHO did not result in weight gain and was effective in males, demonstrated by the reduction in the concentrations of fructosamine (p=0.050) and HbA1C (p=0.041) in M4 compared to M1. Considering the fructosamine, the CCHO group differed from the non-CCHO M4 group (p=0.035). CCHO-associated insulin therapy has been shown to be an important resource to be integrated into the treatment of DM1 to achieve effective targets in reducing complications.

Percepção de Acadêmicos de Medicina e de Outras Áreas da Saúde e Humanas (Ligadas à Saúde) sobre as Relações entre Espiritualidade, Religiosidade e Saúde / The Perception of Medical Students as well as Students from Other Health-Related Areas Regarding the Relations between Spirituality, Religiosity and Health

RESUMO Introdução: Alguns autores encontraram relação estreita e positiva da religiosidade e espiritualidade com comportamentos saudáveis, resultando em saúde adequada. Além disso, dados da literatura sugerem que, de modo geral, as pessoas se apoiam em suas crenças para enfrentar momentos de dificuldades pessoais e coletivas. Os profissionais cujas práticas estão ligadas ao cuidado em saúde necessitam se capacitar para atender e respeitar as manifestações e necessidades dos pacientes no que se refere a religiosidade e espiritualidade. Objetivos: Investigar o que pensam os acadêmicos ingressantes no curso de Medicina e de outras áreas da saúde e humanas acerca do tema; identificar o papel e a importância da religiosidade e espiritualidade em suas vidas e futuras práticas profissionais. Metodologia: Trata-se de estudo quantitativo-qualitativo, descritivo, transversal, de amostra intencional. Entre fevereiro e abril de 2014, foi aplicado aos acadêmicos do primeiro período de Medicina, Biomedicina, Enfermagem, Fisioterapia, Terapia Ocupacional, Educação Física, Nutrição, Psicologia e Serviço Social um questionário que avaliou variáveis sociodemográficas e conceitos que envolvem religiosidade e espiritualidade e saúde. A análise dos dados empregou Qui-Quadrado clássico, feita pelo SPSS versão 2.0, e P < 0,05 foi considerado significante. Resultados: Foram selecionados 270 alunos, de 18 a 43 anos; entretanto, 183 preencheram o questionário, sendo a maioria do sexo feminino, de família convencional, cristã/católica, que herdou a religião dos pais; 78,6% (144/183) referiram afiliação religiosa, 43,5% (87/183) a exercem de forma organizacional. A maioria dos indivíduos considerou que a religiosidade e espiritualidade confere sentido a suas vidas, fortalece em momentos difíceis, traz benefícios à saúde, e considera importante a abordagem de temas relacionados em sua formação acadêmica, enquanto 31,4% (57/183) referiram que houve influência da religiosidade e espiritualidade na escolha profissional. Conclusão: Os alunos das áreas estudadas que ingressaram na Universidade Federal do Triângulo Mineiro manifestaram características positivas relacionadas ao tema religiosidade e espiritualidade, e têm expectativa de uma abordagem mais integral e espiritual do homem na grade curricular.

ABSTRACT Introduction: Some authors have found close and positive relationship between religiosity and spirituality and healthy behaviors that result in good health. Furthermore, data drawn from the literature suggest that, in general, people rely on their beliefs to face moments of personal and collective difficulties. Professionals whose practices are linked to health care, need to be trained to meet and observe the needs of patients, in terms of religiosity and spirituality. Objective: To investigate what medical students as well as students in the health area think about this topic, in addition to identifying the role and importance they attribute to religiosity and spirituality in their lives and future professional practices. Methodology: This was a quantitative and qualitative, descriptive, cross intentional sample study. We applied a questionnaire to first-year students of medicine, biomedicine, nursing, physiotherapy, occupational therapy, physical education, nutrition, psychology and social service, which assessed socio-demographic variables and concepts involving religiosity and spirituality and health. For the data analysis, we used the Chi-Square test developed in SPSS version 2.0, and P<0.05 was considered significant. Results: We selected 270 students, aged between 18 and 43, however, only 183 completed the questionnaire. The majority of the respondents were female, who come from conventional Catholic and Christian families, and inherited their religion from their parents; 78.6% (144/183) report religious affiliation, 43.5% (87/183) practice it in a disciplined way. Most the individuals considered that R/S gives meaning to their lives, strengthens them in times of trouble and brings benefits to their health. They also consider religiosity and spirituality and issues related issues as very important to their academic background, whereas 31.4% (57/183) quoted that religiosity and spirituality have influenced their professional choice. Conclusion: Those who have become students at the Universidade Federal do Triângulo Mineiro have a positive attitude towards religiosity and spirituality and expect a more comprhensive and spiritual approach towards their curriculum.

Prevalence of overweight and obesity and associated factors in school children and adolescents in a medium-sized Brazilian city

OBJECTIVES: The objective of this study was to describe the prevalence of overweight and obesity in school children and adolescents in a medium-sized Brazilian city. METHODS: In total, 1,125 children and adolescents between the ages of 5.6 and 18 years from public and private schools participated in the study. The sample included 681 girls and 444 boys. Each subject's weight and height were obtained according to Brazilian guidelines (SISVAN). The triceps (TSF), subscapular (SSF), biceps, suprailiac, femoral and calf skinfolds were measured in triplicate. Body mass index (BMI) was classified as the BMI percentile (BMIP) according to the World Health Organization (WHO) 2007 criteria. The percentage body fat (%BF) was obtained using the equations by Slaughter et al., 1998. Categorical variables were analyzed using the chi-squared test. RESULTS: Overall, 364 participants with excess weight were identified: 17.3% were overweight, and 15.0% were obese. Among the girls, 18.0% were overweight, and 12.5% were obese; among the boys, 15.3% were overweight, and 18.0% were obese. These prevalence rates were higher when the time spent watching TV or participating in media-related activities surpassed 5 hrs/day, when individuals belonged to a higher economic class and when the head of the family had a higher education level (≥12 years). CONCLUSION: It is important to emphasize the need to increase our understanding of factors associated with overweight and obesity, and it is essential to implement measures and policies aimed at reversing this trend, such as stimulating healthy eating habits and physical activity and reducing time spent watching TV and participating in other media activities, including video games and social networking.

Evaluation of clinical and laboratory markers of cardiometabolic risk in overweight and obese children and adolescents

OBJECTIVE: This study analyzed the frequency of cardiometabolic risk markers and metabolic syndrome occurrence in overweight and obese children and adolescents. METHODS: The participants included 161 overweight (n=65) and obese (n=96) individuals aged between 5 and 19 years. Clinical markers were assessed (body mass index, body fat percentage, waist circumference, acanthosis, systolic and diastolic blood pressures, laboratory parameters [glucose, insulin, cholesterol (total and fractions) and triglyceride levels and homeostasis model assessment of insulin resistance (HOMA-IR) index] and leptin and adiponectin levels). The frequency of changes, odds ratios and correlations among markers were determined. Metabolic syndrome was assessed according to International Diabetes Federation criteria. RESULTS: A high frequency of acanthosis (51.6%); increased waist circumference (45.4%), systolic blood pressure / diastolic blood pressure (8.1% / 9.3%), glucose (10%), insulin (36.9%) and HOMA-IR (44.3%) values; and reduced high-density lipoprotein levels (47.2%) were observed. Leptin levels were increased in 95% of obese and in 66% of overweight subjects. Adiponectin was decreased in 29.5% of obese and in 34% of overweight subjects. An odd ratio analysis revealed a greater probability of increased waist circumference (9.0), systolic blood pressure (4.1), triglyceride (2.3) and insulin (2.9) levels and HOMA-IR (3.0) in the obese group than in the overweight group. The clinical and laboratory parameters and leptin levels exhibited significant correlations, whereas adiponectin was negatively correlated with systolic blood pressure. The occurrence rate of metabolic syndrome was 13.6%. CONCLUSIONS: The high frequency of changes in clinical, laboratory and adipokine markers indicates the need for early interventions aimed at preventing cardiometabolic complications in adulthood.

Clonidine-stimulated growth hormone concentrations (cut-off values) measured by immunochemiluminescent assay (ICMA) in children and adolescents with short stature

OBJECTIVES: To establish cut-off values for growth hormone concentrations using clonidine as a secretagogue and an immunochemiluminescent assay as the method of measurement and to analyze the response time as well as the influence of gender, nutritional status and pubertal stage. METHODS: A total of 225 tests were performed in 3 patient groups, categorized as group 1 (normal), group 2 (idiopathic short stature) and group 3 (growth hormone deficiency). Among the 199 disease-free individuals, 138 were prepubertal, and 61 were pubertal. Clonidine (0.1 mg/m2) was orally administered, and the growth hormone level was measured by immunochemiluminescent assay. The growth hormone peak and the difference between the growth hormone peak and the baseline level were then analyzed. Statistical analyses were performed using Student’s t-test or the Mann-Whitney test and Kruskal-Wallis test followed by Dunn’s post hoc test. Cut-off values were determined using a receiver operating characteristic curve. RESULTS: Group 1 and group 2 had no difference in growth hormone peak, gender, body mass index standard deviation score, or pubertal stage. Group 3 exhibited a significantly lower growth hormone peak than the other groups did. The receiver operating characteristic curve demonstrated that growth hormone concentrations ≥ 3.0 ng/mL defined responsiveness to clonidine. In total, 3.02% of individuals in group 1 and group 2 were considered false positive, i.e., these children lacked growth hormone deficiency and had a peak below 3.0 ng/mL. CONCLUSION: Clonidine-stimulated growth hormone concentrations ≥3 ng/mL, as measured by immunochemiluminescent assay, suggest responsiveness to the stimulus regardless of gender, body mass index standard deviation score or pubertal stage.

Factors associated with treatment for latent tuberculosis in persons living with HIV/AIDS / Fatores associados ao tratamento da tuberculose latente em pessoas vivendo com HIV/AIDS / Factores asociados al tratamiento de la tuberculosis latente en personas viviendo con VIH/SIDA

Abstract The aim was to identify factors associated with non-initiation of prophylactic treatment of latent tuberculosis infection (LTBi) in persons living with HIV/AIDS (PLWA), based on a prospective cohort study of PLWA ≥ 18 years of age in two referral services for HIV/AIDS. Of the 232 patients eligible for treatment of LTBi, 69.8% initiated treatment. Following multivariate logistic regression analysis, only treatment in one of the two referral services was associated with non-initiation of treatment for LTBi (p < 0.001). TB incidence in the cohort was 0.6/100 person-years. TB incidence in patients that initiated treatment of LTBi was 0.4/100 person-years, compared to 1.2/100 person-years in those that did not initiate treatment, but the difference was not statistically significant. The study’s most interesting finding was that the main factor associated with the likelihood of treatment for LTBi was the health service where the patient was treated.

Resumo O objetivo foi identificar os fatores associados ao não início do tratamento preventivo para tuberculose (TB) latente (TBLi) em pessoas vivendo com o HIV/AIDS (PVHA). Um estudo de coorte prospectivo foi realizado com PVHA, idade ≥ 18 anos, de dois serviços de referência para HIV/AIDS. De 232 pacientes elegíveis para tratamento da TBLi, 69,8% iniciaram o tratamento. Após análise de regressão logística multivariada, apenas ser tratado em um dos serviços de referência esteve associado ao não início do tratamento para TBLi (p < 0,001). A taxa de incidência de TB na coorte foi de 0,6/100 pessoas/ano. Para os pacientes que iniciaram o tratamento para TBLi, a taxa de incidência de TB foi de 0,4/100 pessoas/ano e para aqueles que não iniciaram, a taxa foi de 1,2/100 pessoas/ano, mas esta diferença não foi estatisticamente significativa. O achado mais interessante deste estudo foi o fato de o principal fator associado ao aumento da probabilidade de ser tratado para TBLi foi a unidade de saúde onde o paciente foi acompanhado.

Resumen El objetivo fue identificar los factores asociados a no iniciar el tratamiento preventivo para la tuberculosis (TB) latente (TBLi) en personas viviendo con VIH/SIDA (PVHA). Un estudio de cohorte prospectivo fue realizado con PVHA, edad ≥ 18 años, de dos servicios de referencia para VIH/SIDA. De 232 pacientes elegibles para el tratamiento de la TBLi, 69,8% iniciaron el tratamiento. Tras el análisis de regresión logística multivariada, simplemente ser tratado en uno de los servicios de referencia estuvo asociado a no comenzar el tratamiento para TBLi (p < 0,001). La tasa de incidencia de TB en la cohorte fue de 0,6/100 personas-año. Para los pacientes que iniciaron el tratamiento para TBLi, la tasa de incidencia de TB fue de 0,4/100 personas-año y para aquellos que no lo iniciaron, la tasa fue de 1,2/100 personas-año, pero esa diferencia no fue estadísticamente significativa. El hallazgo más interesante de este estudio fue el hecho de que el principal factor asociado al aumento de la probabilidad de ser tratado para TBLi fue la unidad de salud donde se realizó el seguimiento del paciente.

Puberty in a sample of Brazilian schoolgirls: timing and anthropometric characteristics

Objective The objective of this study was to determine the age at which puberty begins, age of menarche and anthropometric data of the participants at different stages of puberty. Subjects and methods This is a cross-sectional study in which we evaluated 665 girls, a sample representing the female schoolchildren population in Uberaba. Results We found that thelarche, pubarche, underarm hair and menarche were attained at the age of 9.8 ± 1.4, 10.2 ± 1.4, 10.5 ± 1.5 and 11.7 ± 1.3 years, respectively. The mean interval between thelarche and menarche (ITM) was 1.7 ± 1.3 years. The prevalence of overweight and obesity was 31.3% and 95% of the participants began at thelarche between the age of 7 and 12 years. Conclusion These values indicate a secular tendency to the decrease of the age of menarche and an earlier start of puberty. It is very important to understand these parameters to establish public policies aimed at plans to prevent these early events, especially regarding control of the prevalence of obesity. .

Palatal rugoscopy as a method of human identification / Rugoscopia palatina como método de identificação humana

Test the applicability of the formula in palatoscopy.Methodology: three observers examined 30 plaster models of the upper arch, obtained from dentistry students at the Universidade Federal da Paraiba (UFPB). Rugae were classified as simple and composed and as line, curve, angle, circle, sinuous and point.Results: the intra-observer examination of simple and compound rugae showed a higher coincidence percentage for composed rugae (53.3 to 56.7%), as did inter-observer examinations (43.3% to 55.0%), compared to the 5% - 23.3% obtained for simple rugae. Analysis of the main types revealed that circular rugae showed the highest coincidence percentage (95.0% to 96.7%), followed by angular (61.7% to 66.7%). The line rugae demonstrated the lowest coincidence percentage (11.7% to 45.0%). Inter-observer coincidences were highest in the circle rugae (93.3% to 96.7%) and lowest in the line rugae, with percentages between 16.7% and 15.0%. The higher percentage of composed rugae reflected its good visualization. The high observer agreement in relation to circular rugae is due to the classification of their absence, since this rugae is seldom found, in contrast to line rugae, which are mistaken for wavy rugae and vice versa, often present in the palate. It can be observed that palatal rugae as a method has a large number of classifications, but with low practicability, storage difficulties and absence of universal standards...

Testar a aplicabilidade da fórmula na rugoscopia palatina.Metodologia: três avaliadores examinaram 30 modelos em gesso do arco superior, obtidos de estudantes de Odontologia da UFPB. As rugosidades foram classificadas em simples e compostas e em reta, curva, angular, circular, sinuosa e ponto.Resultados: o exame das rugas simples e compostas, intra avaliador, demonstrou maior percentual de coincidência para as rugas compostas (53,3 a 56,7%), assim como nos exames inter avaliadores, com acertos entre 43,3% e 55,0%, confrontando com os 5,0% e 23,3% obtidos nas rugas simples. Na análise dos tipos fundamentais observa-se que as rugas circulares apresentaram maior percentual de coincidências (95,0% a 96,7%), seguida das angulares (61,7% a 66,7%). A ruga reta demonstrou menor percentual de coincidências (11,7% a 45,0%). As coincidências inter avaliadores foi maior nas rugas circulares (93,3% a 96,7%) e menor nas rugas retas, com percentual entre 16,7% e 15,0%. O maior percentual das rugas compostas demonstra a sua boa visualização. A alta concordância dos avaliadores quanto a rugas circulares ocorre em virtude da classificação de sua ausência, pois raramente se encontra esta ruga, diferente das retas, que se confundem com as sinuosas e vice-versa, frequentemente presentes no palato. Nota-se que a rugosidade palatina como método possui uma grande quantidade de classificações, porém, com praticabilidade baixa, de difícil arquivamento e ausência de padrão universal.Conclusão: a classificação das rugosidades palatinas, por meio da fórmula rugoscópica, não é aplicável devido à subjetividade do método...

Body mass index in individuals with HIV infection and factors associated with thinness and overweight/obesity / Índice de massa corporal em indivíduos com infecção pelo HIV e fatores associados com magreza e sobrepeso/obesidade

A cross-sectional study was conducted using body mass index (BMI) to estimate the prevalence of thinness and overweight/obesity and associated factors in 2,018 individuals with HIV/AIDS attending health services referral centers. The dependent variable was classified as thinness, overweight/obesity and eutrophy. Multinomial logistic regression analyses were performed considering eutrophy as the reference level. The prevalence of thinness was 8.8 percent and of overweight/obesity, 32.1 percent. The variables associated with thinness were anemia and CD4 cell count < 200mm³. The variables associated with risk of overweight/obesity were age > 40 years and diabetes, and the variables identified as decreasing likelihood of overweight/obesity were having no long-term partner, smoking, presence of an opportunistic disease, anemia, and albumin levels < 3.5mg/dL. The main nutritional problem observed in this population was overweight and obesity, which were much more prevalent than thinness. Older individuals with diabetes should be targeted for nutritional interventions and lifestyle changes.

Estudo seccional para estimar a prevalência de magreza e sobrepeso/obesidade e fatores associados em 2.018 indivíduos com HIV/AIDS, atendidos em serviços de referência em Recife, Pernambuco, Brasil, utilizando o índice de massa corporal. A variável dependente foi classificada como magreza, sobrepeso/obesidade e eutrofia. Realizou-se análise de regressão logística multinomial considerando-se como referência os eutróficos. A prevalência de magreza foi de 8,8 por cento e a de sobrepeso/obesidade de 32,1 por cento. Permaneceram associados à magreza ter anemia e contagem de células TCD4 < 200mm³. Os fatores associados à maior chance de sobrepeso/obesidade foram: idade > 40 anos e presença de diabetes, e aqueles inversamente associados com sobrepeso/obesidade: não ter companheiro fixo, tabagismo, história recente de doença oportunista, anemia e níveis de albumina < 3,5mg/dL. O principal desvio nutricional observado foi o sobrepeso/obesidade, superando a magreza. Os indivíduos mais velhos com diabetes devem ser alvos de intervenções nutricionais e de estilo de vida.

Estudo retrospectivo das implicações maternas, fetais e perinatais em mulheres portadoras de diabetes, em 20 anos de acompanhamento no Hospital Escola da Universidade Federal do Triângulo Mineiro / Retrospective study of the maternal, fetal and perinatal outcomes in diabetic women in twenty years of assistance in the Universidade Federal do Triângulo Mineiro School Hospital

OBJETIVOS: Avaliar implicações do diabetes melito (DM) na morbimortalidade materno-fetal, segundo experiência da Universidade Federal do Triângulo Mineiro. MATERIAIS E METODOS: Procedeu-se à análise retrospectiva dos prontuários de gestantes diabéticas assistidas entre 1990 e 2009 focando dados e complicações maternas e neonatais. RESULTADOS: A última gestação de 93 diabéticas foi avaliada, sendo 34 com DM tipo 1, em que se observou maior ocorrência de tocotrauma (p = 0,023) e retinopatia (p = 0,023). Vinte e uma pacientes tinham DM tipo 2; suas necessidades de insulina aumentaram progressivamente (p < 0,01) e observou-se maior prevalência de tabagismo (p = 0,004). Trinta e oito tiveram diabetes gestacional e iniciaram acompanhamento do diabetes em idade gestacional mais tardia (p < 0,001), tiveram mais antecedentes de macrossomia fetal (p = 0,028) e maior prevalência de fatores de risco cardiovascular. CONCLUSÕES: Não obstante melhora do controle glicêmico durante a gestação, nenhum dos grupos atingiu alvos glicêmicos ideais. Ainda assim, a maioria das gestações em diabéticas, conduzidas em nosso meio, evoluiu favoravelmente.

OBJECTIVES: Evaluation of the consequences of diabetes mellitus (DM) on maternal and fetal morbidity and mortality at Universidade Federal do Triângulo Mineiro. MATERIALS AND METHODS: A retrospective review of medical records of pregnant women with diabetes was carried out at the hospital between 1990-2009, focusing on maternal and neonatal data and complications. RESULTS: The last pregnancy of 93 diabetics was evaluated. In thirty-four patients with type 1 diabetes a higher incidence of birth trauma (p = 0.023) and retinopathy (p = 0.023) was observed. Twenty-one type 2 DM subjects required progressively increased insulin therapy (p < 0.01) and showed a higher prevalence of smoking (p = 0.004). Thirty-eight had gestational diabetes. Their diabetic follow-up started at a later gestational age (p < 0.001), had more fetal macrosomia histories (p = 0.028) and cardiovascular risk factors. CONCLUSIONS: Despite improvement of glycemic control during pregnancy neither group attained the glycemic target. However, the majority of DM pregnancies evaluated in our group presented successful outcomes.

Avaliação da estatura final atingida por pacientes com diabetes melito tipo 1 acompanhados em serviço terciário / Evaluation of the final stature reached by type 1 diabetes mellitus patients followed at an outsourced service

As alterações metabólicas decorrentes do diabetes melito tipo 1 (DM1) podem prejudicar o crescimento e o desenvolvimento. OBJETIVO: Avaliar a estatura final de pacientes com DM1 e a interferência da doença no crescimento. PACIENTES E MÉTODOS: A estatura final de 58 pacientes com DM1 foi avaliada em relação aos dados antropométricos e controle metabólico. RESULTADOS: A idade média foi de 26,4 anos (15,0-51,0) e a duração da doença, de 9,6 anos (1,4-25,0). A estatura final foi 165,1 cm (149,3-183,0) e o z-escore da estatura final foi igual a 0,09 (-1,76-2,85). Num subgrupo (n = 34), foi possível avaliar o controle glicêmico durante a fase de crescimento estatural. A média de hemoglobina glicosilada foi 12,2 por cento (6,8-24,1) e as correlações entre dados antropométricos e controle glicêmico não foram estatisticamente significantes (p > 0,05). CONCLUSÃO: Não houve interferência do DM1 na estatura final, apesar do controle glicêmico inadequado.

Metabolic changes resulting from type 1 diabetes mellitus (DM1) may put growth and development at risk. OBJECTIVE: To evaluate the final stature of DM1 patients and the interference of DM1 in growth. SUBJECTS AND METHODS: The final height reached by 58 DM1 patients was evaluated according to anthropometric data and metabolic control. RESULTS: Mean age was 26.4 years (15.0-51.0) and the duration of disease was of 9.6 years (1.4-25.0). Final stature was 165.1 cm (149.3-183.0) and the z-score for height was 0.09 (-1.76-2.85). In a subgroup (n = 34), it was possible to evaluate the effect of metabolic control on growth. Mean glycosylated hemoglobin was 12.2 percent (6.8-24.1) and the correlation between anthropometric data and glucose control was not considered statistically significant (p > 0.05). CONCLUSION: We conclude that DM1 had no effect on the final stature, to the detriment of a poor metabolic control.

Interpretation of mandibular condyle fractures using 2D- and 3D-computed tomography

A tomografia computadorizada (TC) tem sido cada vez mais utilizada para exames de pacientes portadores de traumas craniofaciais. Essa técnica tem apresentado vantagens no exame da articulação temporomandibular, sendo também empregada com sucesso no diagnóstico de fraturas de côndilo. Com o propósito de verificar se a reconstrução em 3 dimensões de imagens de TC (3D-TC) acrescenta informação visual às interpretações baseadas em imagens de 2D-TC, o presente trabalho avaliou qualitativamente exames realizados segundo ambas as técnicas em 18 pacientes portadores de fraturas por trauma do côndilo mandibular. Os resultados indicaram que a 2D-TC e a 3D-TC apresentaram informações similares para o diagnóstico dessas fraturas. Contudo, as imagens reconstruídas em 3D-TC forneceram indicações mais precisas quanto à posição anatômica da fratura, deslocamento dos fragmentos ósseos e presença de cominução nas fraturas. Estes resultados, aliados à possibilidade de refinamento e manipulação em vários ângulos das imagens em 3D, sublinham sua aplicabilidade no planejamento e acompanhamento cirúrgico daquelas fraturas. Concluiu-se que a técnica de 3D-CT apresentou informações suplementares para um diagnóstico mais preciso das fraturas de côndilo mandibular.

Validade da tomografia computadorizada para diagnóstico de fraturas crânio-faciais, utilizando uma estaçäo de trabalho independente / Validity of computed tomograph for diagnosis of craniofacial fractures using an independent workstation

Este trabalho teve como objetivo demonstrar a sensibilidade e a especificidade da TC para diagnóstico de fraturas crânio-faciais, utilizando um protocolo por meio do Multislice CT e aplicaçäo de um programa volumétrico com propriedades da computaçäo gráfica, o qual gerou as RMP e as reconstruçöes em 3D, em uma estaçäo de trabalho independente. Foram analisados 25 pacientes submetidos ao exame por tomografia computadorizada (TC) com cortes axiais. Os dados originais foram transferidos para a estaçäo de trabalho independente e as imagens em axial, RMP e em 3D foram interpretadas por 2 examinadores, independentemente. Por ultimo foram associadas as três técnicas (AxialRMP3D) e também interpretadas. Os achados pós-cirúrgicos foram considerados o padräo ouro deste trabalho, os quais foram comparados em relaçäo à presença e localizaçäo das fraturas crânio-faciais. Os resultados foram apresentados de maneira global e por regiöes selecionadas (regiäo de maxila, orbitária, de mandíbula e de zigomático) e näo demonstraram diferenças estatisticamente significantes entre os quatro métodos. Entretanto a associaçäo AxialRMP3D indicou maiores valores percentuais de sensibilidade e especificidade para o diagnóstico de fraturas crânio-faciais (95,8 porcento e 99 porcento, respectivamente), inclusive para as regiöes anatômicas observadas separadamente, com exceçäo da regiäo orbitária, onde apresentou total equilíbrio em relaçäo às demais técnicas. Pôde-se concluir que a utilizaçäo deste protocolo, empregando o Multislice TC e a associaçäo das técnicas, promoveu melhor interpretaçäo radiográfica das fraturas crânio-faciais, com refinamento da qualidade das reconstruçöes, bem como rapidez na interpretaçäo das mesmas, possibilitando o acréscimo de importantes informaçöes e demonstrando a validade da TC para diagnóstico de fraturas crânio-faciais, utilizando uma estaçäo de trabalho independente