ABSTRACT
ABSTRACTThe aim of this study is to investigate the effect of Cecropia glaziovii Snethl, Urticaceae, extracts on the oral glucose tolerance curve, on glycemia in alloxan-induced diabetic rats and vasorelaxant effect after the extraction process, and to standardize the extractive solutions. The effects of the process variables and their interactions were calculated in relation to dry residue, pH, total phenolic results and chemical marker content. Furthermore, the effect of the extracts (400 mg/kg), chlorogenic (2 or 15 mg/kg) and caffeic acids (2 mg/kg) were investigated on the oral glucose tolerance curve and on glycemia in alloxan-induced diabetic rats. Oral administration of ethanol extracts 4d20 and 8d20 significantly improved glucose tolerance in the hyperglycemic rats. Chlorogenic and caffeic acids, as well as the association of the compounds were able to significantly reduce glycemia after oral gavage treatments. On the other hand, the aqueous extracts did not alter the glycemia. The aqueous extracts (8020 and 9030) and only the higher dose of chlorogenic acid presented a significant effect on serum glucose lowering in diabetic rats. Additionally, the IC50 reveals that the ethanol extracts presented more potent vasodilator effects than the aqueous extracts in aortic rings. This study shows that C. glazioviistandardized extracts exhibits antihyperglycemic action, is able to improve glucose tolerance and has a potent vascular relaxing effect. These results are probably linked to concentrations of the main phenolic compounds of the extracts.
ABSTRACT
OBJECTIVE: To identify the prevalence of overweight and its associated factors among university students of the area of health. METHODS: The sample comprised 344 students. Body Mass Index (BMI) and associated factors were assessed from a self-report questionnaire. Students who presented BMI ≥25 kg/m² were rated overweight. Statistical analysis was performed using the chi-square test and associations were estimated by odds ratio with 95% (95% CI). The prevalence of overweight students was 23.8% overall. RESULTS: Factors associated with overweight were as follows: male (OR=3.773: CI=2.152-6.614); not living in the city where one studies (OR=1.830: CI=1.104-3.034); attending the final years of an undergraduate course (OR =1.758: CI=1.066-2.897); attending night classes (OR=1.654: CI=1.004-2.726); alcohol consumption (OR=1.676: CI=1.014-2.769); smoking (OR=3.914: CI=1.458-10.506); and working (OR=2.029: CI=1.222-3.366). CONCLUSION: The groups with the highest risk of overweight were male students who live in other cities, attend the final years, study at night, consume alcohol and tobacco, and work
OBJETIVO: Identificar a prevalência de excesso de peso e os fatores associados em universitários da área da Saúde. MÉTODOS: A amostra foi constituída por 344 acadêmicos. Índice de Massa Corpórea (IMC) e fatores associados foram avaliados a partir de um questionário de autorrelato. Foi classificado com excesso de peso aquele estudante que tivesse IMC ≥ 25 kg/m². A análise estatística foi realizada por meio do teste qu i-quadrado e as associações foram calculadas pelo odds ratio 95% (IC95%). RESULTADOS: A prevalência de excesso de peso geral foi de 23,8%. Os fatores associados ao excesso de peso foram: ser do sexo masculino (OR = 3,773: IC = 2,152-6,614); não morar na cidade em que estuda (OR = 1,830: IC = 1,104-3,034); estar cursando as séries finais do curso de graduação (OR = 1,758: IC = 1,066-2,897), estudar no período noturno (OR = 1,654: IC = 1,004-2,726), consumir bebidas alcoólicas (OR = 1,676: IC = 1,014-2,769), fumar (OR = 3,914: IC = 1,458-10,506) e trabalhar (OR = 2,029: IC = 1,222-3,366). CONCLUSÃO: Os grupos com maior risco de excesso de peso foram estudantes do sexo masculino, que vivem em outras cidades, participam de séries de estudo finais, à noite, consomem álcool, usam tabaco e trabalham