A Aminofilina Antagoniza a Açäo do Midazolan / Aminophylline Antagonizes Midazolan-Induced Sedation

The efficacy of aminophylline in antagonizing midazolam-induced sedation was evaluated in a double-blind study involving 60 patients scheduled for epidural anesthesia. Premedication consisted of sublingual flunitrazepam 2mg. Intraoperative sedation was achieved with intermitent intravenous bolus of midazolam 1mg. At the end of the surgery patients received either aminophyline 2mg/Kg (Group A), flumazenil 0.01mg/Kg (Group F) or placebo 0.1 ML/Kg (Group P) intravenously. Central nervous system functions were evaluated according to the degree of sedation, orientation, and cooperation presented. At the end of the surgery sedation was such that no patient was "completely awake". Fifteen minutes after the "antagonist" drug was administered, 35 percent of the patients in Group A, 100 percent in Group F, and 0 percent in Group P were "completely awake". Regarding orientation, 5 percent vs 55 percent in Group A, 0 percent vs 100 percent in Group F and 10 percent vs - 15 percent in Group P were "completely oriented" before vs after the drugs. Regarding cooperation, 5 percent vs 70 percent in Group A, 5 percent vs 100 percent in Group F, and 15 percent vs 15 percent in Group P were "completely cooperative" before vs after drugs. It is suggested that aminophylline can be used for reversal of midazolam action, although it is less effective than flumazenil

Estudo da visao de cores realizado na UFSC / Study of the vision of colore at UFSC

Os autores pesquisaram a visao de cores em 390 pessoas adultas, estudantes de medicina, medicos e funcionarios da Universidade Federal de Santa Catarina, sendo 179 do sexo feminino e 211 do sexo masculino. Encontraram uma frequencia global de 7,17 por cento de deficientes visuais para cores, sendo 6,66 por cento no sexo masculino e 0,51 por cento no sexo feminino. A grande maioria das 390 pessoas examinadas pertencia aos grupos etarios compreendidos entre 17 e 41 anos. Nao foi possivel estabelecer relacao entre a frequencia de deficiencia de visao para cores com as diferentes categoria profissionais. Em torno de 57 por cento das pessoas com discromatopsia conheciam sua deficiencia de visao para cores. Entre as 28 pessoas com discromatopsia, apenas duas relataram dificuldades com a sinalizacao de transito, o que nao as impossibilitava de conduzir veiculos automotores. Constatou-se tambem que 20 por cento das pessoas com discromatopsia conhecem familiares portadores de deficiencia visual para cores. Finalmente, os autores tambem concordam com as alteracoes na legislacao para habilitacao de motoristas e na sinalizacao de transito.