ABSTRACT
Leptin, a pleiotropic cytokine, regulates various metabolic and endocrine responses, has emerged as an important regulator of inflammation. Also, hyperleptinemia has been reported as a component of metabolic syndrome. Association between periodontitis, pregnancy and cardiovascular risk has been suggested. Hence, the present study was planned to study gingival crevicular fluid [GCF] leptin concentrations in pregnant women with and without periodontitis. Twenty five pregnant women with periodontitis and 10 pregnant women as a control were recruited. Leptin [GCF] leptin concentrations were analyzed by competitive ELISAkit. The leptin levels were significantly lower in pregnancy periodontitis patients as compared to normal pregnant women [p<0.01]. The higher leptin GCF levels in pregnant women without periodontitis may have a protective role in periodontal disease. Further studies are required to clarify role of GCF leptin, and the possibility of leptin receptors in gingiva and periodontal ligament in pathogenesis of periodontal disease in pregnancy and future cardiovascular risk
Subject(s)
Humans , Female , Gingival Crevicular Fluid , Pregnancy , Periodontitis , Enzyme-Linked Immunosorbent AssayABSTRACT
To determine the association between levels of salivary thiocynate and periodontitis. One hundred thirty eight samples were screened of which smokers with periodontitis were [n=35], periodontitis in non-smokers [n=33], healthy periodontium in smokers [n=38] and healthy periodontium [n=32], were recruited for the study and salivary thiocynate levels were analyzed. Salivary levels of thiocynate were significantly higher in smokers with periodontitis in smoker as compared to others. Thus, measurement of salivary thiocynate may prove to be useful in early detection of periodontal disease
Subject(s)
Humans , /diagnosis , Biomarkers , Smoking , SalivaABSTRACT
Periodontal disease is an inflammatory disorder in which tissue damage occurs through complex interactions between periodontal pathogens and components of the host defense mechanisms and oxidative stress is implicated in pathophysiology. Twelve subjects with periodontitis were selected and salivary samples were taken before treatment, after 3 weeks of treatment and after 10 weeks of the treatment for 8-OHdG levels [8-Hydroxydeoxyguanosine]. Salivary levels of 8-OHdG were significantly decreased with scaling and root planning. Thus, measurement of 8-OHdG may prove to be useful in identifying periodontal disease and risk of tooth loss
ABSTRACT
To determine the association between levels of a marker of oxidative stress, 8- hydroxydeoxyguanosine [8-OHdG], in saliva and presence of periodontitis in smokers and non-smokers. Forty subject samples, as healthy control [n=16], periodontitis in smokers [n=11] and periodontitis in non-smokers [n=13] were recruited for the study. The 8-OHdG were analyzed in the saliva of smoking and non-smoking patients of periodontitis and healthy control. Salivary levels of 8-OHdG were significantly higher in subject with periodontitis who smoked as compared to non-smoker [6.82 + 0.18 ng/ml and 4.83 + 0.16 ng/ml]. Thus, measurement of 8-OHdG may prove to be useful in identifying periodontal disease and risk of tooth loss