ABSTRACT
The histopathological study of 61 cases of peripheral intrahepatic cholangiocarcinoma was reported. Of the 5 autopsied livers and 13 surgically resected livers, 89 per cent showed massive gross appearance, 94 per cent contained Opisthorchis viverrini or showed evidence of previous opisthorchiasis. Gall stones were found in 7 cases (11.5%), common bile duct stones were found in one case. The tumors were classified into well differentiated, less differentiated and uncommon types (adenosquamous, anaplastic and mucinous) which were found in 14.66, 70 and 13.66 per cent respectively. Of the 61 liver specimens, 92 per cent produced mucin and 53 per cent had more than one histological types. The important routes of intrahepatic spreadings were lymphatic involvement (90%) and permeation into the portal connective tissue (80%). One case of combined hepato-cholangiocarcinoma was observed in a cirrhotic liver containing Opisthorchis viverrini and positive HBsAg.