ABSTRACT
The aim of the present study is to identify the incidence of Dissociative Stupor and Possessions in psychiatry OPD population. 8.92% of patients in last 10 years were in the screening group. There were 10.03% of the subjects in 2007 sliding through to 7.76% in 2016, a visible decline. Males are affected earlier (mean age 18.59 years) than females (mean age 23.4 years). The study also proved that females far outnumber males in this category of illness but in the ages between 6 to 12 years, this relationship is reversed.
ABSTRACT
Carbonic anhydrase (CA) inhibitors are very interesting target for designing anticancer (hypoxic) and antiglaucoma drugs. In the present study, a 3D homology modeling of human carbonic anhydrase-IX (hCA-IX) isozyme, based upon the crystal structure of murine CA-XIVA (PDB CODE 1RJ5) was performed, as no experimental 3D structures are available. A homology model of hCA-IX was developed and validated. To explore the responsible physicochemical properties of 1,3,4-thiadiazole and 1,3,4-triazole derivatives for carbonic anhydrase inhibition, a quantitative structure activity relationship (QSAR) study was performed having hCA-II and hCA-IX inhibitory activity respectively. In hCA-II and hCA-IX inhibitory activities, four significant models with good correlations ( 0.945 & 0.926) were obtained; two models (models 1 and 3) were selected based on statistical criterion. The QSAR study revealed that in case of hCA-II, overall increase in size and volume of molecule, introduction of electropositive surfaces might increase the inhibitory activity, whereas in case of hCA-IX, decreasing the hydrophobicity and introduction of electron releasing substituents might increase the hCA-IX inhibitory activity.