ABSTRACT
Background: There is an established link between Hyperleptinemia and Obesity. Leptin resistance, characterized by elevated levels of circulating leptin together with disruption of hormone signalling, is an important feature of obesity. Hyperleptinemia has been demonstrated to correlate with insulin resistance. Aims and Objectives: Evaluation of Leptin In Obese and Non - Obese Diabetics. Methods: This cross - sectional study aimed to evaluate the levels of lepti n in non - obese and obese and its relationship. A total of 30 obese diabetics and 30 non - obese diabetics were involved in the study which was conducted in the Department of Physiology, Jawaharlal Nehru Medical College, Aligarh. Collected blood samples were estimated for HbA1C and leptin levels. Body Fat was estimated using Body Stat in Non - Obese Diabetics and Obese Diabetics. Results: In this study, Leptin levels were significantly higher in obese diabetics compared to non - obese diabetics. Data presents cor relations between leptin in obese with HbA1C, BMI, and Body Fat in Obese Conclusion: Elevated Leptin Levels is a strong marker of obesity which suggests Leptin Resistance
ABSTRACT
Background: Thyroid hormones play critical roles in differentiation, growth, and metabolism. Thyroid hormone play important role in development of Central Nervous System and in myelination of neurons. hypothyroidism is a chronic and insidious disease caused by failure of thyroid hormone production mostly due to inflammation, thyroidectomy, use of I131, and anti-hyperthyroidism drugs. Involvement of Peripheral nerve is frequent in hypothyroid patients. Objective of study: To evaluate the dysfunction of Sensory Nerve in Hypothyroid patients. Methods: 30 patients of hypothyroidism were included in the study, detailed history and clinical examination was performed. 30 normal subjects were included as control. Nerve Conduction Studies were performed in neurophysiology lab of Physiology dept of JNMC Aligarh. Results: While comparing the Sensory Nerve Conduction velocity of Median nerves between the two groups, the Sensory NCV of right Median (44.59±8.39) is found to be significantly decreased in hypothyroid subjects. While comparing the Sensory latency of Median nerve between the two groups, the latency of right median nerve (3.69±.69), left median nerve (3.43±.80) is significantly increased bilaterally in hypothyroid subjects. Conclusion: Hypothyroidism is a definite cause of neuropathy, it affects sensory nerves first than motor nerves. We suggest performing electrophysiological studies in hypothyroid patients, even asymptomatic patients in an early course of disease. So we can prevent the progression of neuropathy
ABSTRACT
Background: Neurodegenerative diseases are those affect the central nervous system (brain, spinal cord) and peripheral nervous system. It is characterized by progressive loss of neurons and synapses in these nervous systems. Calcium homeostasis receives key attention in the past few years in the field of neuronal physiology of Ageing and Neurodegenerative diseases. Objective: The aim of this study was to evaluate Calcium homeostasis in patients with Neurodegenerative diseases. Methods: 50 subjects (36 males and 14females) with Neurodegenerative diseases. And same number of healthy age-matched subject control group was assessed. A complete & detailed neurological examination were performed in all individuals and clinically evaluated for the occurrence of Neurodegenerative diseases. Calcium levels were estimated using (Instrumentation Laboratory – IlyteTM) Automated Electrolyte Analyzer, with solution pack and reagents. Results: ‘The Serum Calcium (Ca2+) levels were estimated and comparison was done in both control and case group separately, for evaluating the changes due to ageing and in particular to neurodegenerative diseases. Conclusion: Neurodegenerative diseases showed significant differences in Calcium homeostasis.
ABSTRACT
Background: Obesity is an epidemic in 21st century especially rising among young population of developing nations is measured in terms of BMI (Body Mass Index). It affects almost every system. In present study we aim to investigate any correlation between NCV & BMI among professionals of mechanized jobs involving repeated wrist movements. Method: BMI and median nerve NCV is measured in dominant and non-dominant hand of young active professionals. Results: One way ANOVA is applied and MNCV of median nerve in dominant hand and SNCV of dominant as well as non-dominant hand is found to be significantly decreased but MNCV of non-dominant shows no significant difference. Conclusion: Early changes in nerve conduction due to increased carpal tunnel pressure are more pronounced in dominant hand and SNCV of median nerve could be used as an early screening and diagnostic tool for median neuropathy
ABSTRACT
Background: Nerve Conduction Velocity is affected by various factors like age gender & temperature. Various studies have been done regarding development of brain and dominance of right or left side, some studies have found differences between left and right hand for nerve conduction. Our aim is to compare NCV of dominant limb to nondominant limb in right hand dominant subjects and to find out if different normal values should be considered in right and left hand. Methods: The Median and Common Peroneal Nerve (CPN) of dominant as well as Non- dominant limb were used for measuring Motor & Sensory Nerve Conduction Velocity (MNCV & SNCV) in age groups of 31-35 and 36- 40 years using Medicaid system. Results: We found p value was insignificant using unpaired t-test for MNCV & SNCV of Median and Common Peroneal Nerve of left and right side. Similarly, the MNCV & SNCV of dominant and nondominant limb for median and CPN were insignificant. Conclusion: Consideration of right or left side dominance is not necessary while measuring NCV in asymptomatic subjects and different set of normal values are not required for right and left hand.
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Objective: To study the cardiovascular risk factors exposed to tobacco chewing and compare these findings with that of smokers and control subjects. Methods: This study was conducted at Jawaharlal Nehru Medical College, Aligarh. 180 subjects were included in this study. The subjects were divided in three groups. Group I (Tobacco chewers-chewed nicotine), Group II (Smokers-smoked nicotine) and Group III (control subjects). Each group consists of 60 subjects. Various anthropometric and cardiovascular parameters were recorded and compared among these three groups. Results: Significant difference was found for weight and body mass index (p<0.001) between smokers and control subjects. When compared to control subjects, tobacco chewers had significantly higher pulse rate (p<0.001), systolic blood pressure (p<0.011), diastolic blood pressure (p<0.004) and mean arterial pressure (p<0.001) but no significant difference was found between tobacco chewers and smokers.
ABSTRACT
Background: The beneficial effects of exercise on plasma lipids have been widely explored. These changes depend upon the type of sports in which one is indulged. The aim of the present study was to analyze these changes in different sportspersons. Methods: 32 male sportspersons participating in 3 different games in the university were selected for this study. Lipid profile of the three groups was compared to each other. Results : Total Cholesterol (TC), Triglyceride (TG) and Low Density Lipoprotein (LDL) levels were found to be significantly lower in distance runners as compared to football players and basketball players . Whereas High Density Lipoprotein (HDL) level was found to be significantly increased in runners as compared to other groups. Conclusion: The results of this study suggest that the lipid profile is more favourable in sports involving more aerobic activity with less physical stress.