Changes in the serum cartilage biomarker levels of healthy adults in response to an uphill walk

<p><b>INTRODUCTION</b>To prevent long-term unfavourable consequences to the articular cartilage of weight-bearing joints, serum biomarkers can be used to identify optimum loading of activities. This study aimed to investigate the circulation pattern of serum cartilage biomarkers in healthy adults in response to an uphill walk.</p><p><b>METHODS</b>This study recruited 58 healthy participants for the experimental group and 24 matched participants for the control group. Participants in the experimental group walked continuously for 14 km on a pathway with a 5.97° incline, while participants from the control group walked on a horizontal pathway. Serum was collected from both groups preactivity (i.e. T1), immediately after activity (i.e. T2) and 24 hours after T1 (i.e. T3). The serum cartilage oligomeric matrix protein (COMP), chondroitin sulfate-WF6 (WF6) and hyaluronic acid (HA) levels at each time point were quantified using enzyme-linked immunosorbent assays, and the results analysed.</p><p><b>RESULTS</b>Both groups shared similar demographic characteristics and activity duration. At T2, the serum COMP level of the experimental group was significantly higher than that of the control group, but the serum HA level of the experimental group was significantly lower than that of the control group. No significant difference between the serum WF6 levels of the experimental and control groups was observed at T2.</p><p><b>CONCLUSION</b>Increasing levels of serum COMP demonstrate articular cartilage susceptibility to the increasing load. An unsustainable, high serum COMP level and an undetectable change in WF6 level were considered to be a reversible physiological change of the cartilage. A change in ser um HA level could be related to intensive physical activity and dynamic clearance rather than a change in cartilage structure.</p>

A MODIFIED PIN AND WIRING TECHNIQUE FOR OCCIPITOCERVICAL FUSION IN A CHILD WITH OCCIPITALIZATION OF THE ATLAS: A CASE REPORT

A rare case of occipitalization of the atlas with spinomedullary compression was reported. Thechild presented with neck pain and quadriplegia. Radiographic images showed occipito-atlantalinstability. Posterior stabilization was performed using a contoured pin modifi ed in Maharaj NakornChiang Mai Hospital, wiring, and strut bone grafts between the occiput and C4 vertebra. Use of themodifi ed pin and wiring technique, as described herein, achieved solid bone fusion and maintainedstable constructs. The patient has shown symptomatic improvement and no remarkable complicationsafter 5 years postoperatively.Chiang Mai Medical Journal 2010;49(1):35-39.