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Indian J Exp Biol ; 1990 Jan; 28(1): 10-7
Article in English | IMSEAR | ID: sea-59667

ABSTRACT

In this study initially a precancerous condition, leukoplakia, was develop at 6 weeks treatment of DMBA whereas in the animals treated both DMBA + Vit. A, leukoplakia was seen at 10 weeks followed by papilloma or nodules at 12 weeks. Tumours induced by DMBA were more in number than DMBA + Vit. A treated tumours. The histological and ultrastructural changes were enhanced and prominent in DMBA treated animals at 12 weeks, where as these changes were considerably less in animals treated with DMBA + vit. A at 12 weeks.


Subject(s)
9,10-Dimethyl-1,2-benzanthracene/toxicity , Animals , Cricetinae , Female , Leukoplakia, Oral/chemically induced , Male , Mesocricetus , Microscopy, Electron , Mouth Neoplasms/chemically induced , Papilloma/chemically induced , Vitamin A/pharmacology
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