ABSTRACT
Circular RNAs (circRNAs) are a class of highly stable,long non-coding RNAs (lncRNAs),which shows greater conserved across species and highly specific in different tissue and development stage.There are numerous circRNAs in the central nervous system,which are not only closely related to development,differentiation and biological function of neuronal cells,also play a crucial role in nerve lesions and dysfunction after brain injury.Specific circular RNA could contribute to the regulation of gene expression by acting as miRNA sponges,involving in the protection against apoptosis in neurons and regeneration after brain injury.A comprehensive understanding of the specific circular RNA function and its underlying mechanism in the brain can provide a new strategy for the prevention,diagnosis,and treatment of brain injury at gene level.