ABSTRACT
Objective:To investigate the influencing factors of hyperuricemia(HUA) and explore early intervention of metabolic diseases.Methods:A total of 70 523 participants were selected from the database of check-ups in 2016. Univariate analysis and logistic regression analysis were used to identify related factors of HUA. Correspondence analysis was performed for the aggregation of different levels of uric acid(UA) and related factors. The mediating effect of mean blood pressure(MBP) between abnormal metabolic indicators and abnormal renal function was tested.Results:The age, sex, occupation, body mass index(BMI), systolic blood pressure, diastolic blood pressure, blood urea nitrogen(BUN), creatinine(Cr), estimated glomerular filtration rate(eGFR), fasting plasma glucose(FPG), total cholesterol(TC), triacylglycerol(TG), high density lipoprotein-cholesterol(HDL-C), low density lipoprotein-cholesterol, plasma viscosity were significantly related to HUA( P<0.001). Logistic regression analysis showed that youth, male, hypertension, TC, TG, and Cr were risk factors for HUA, while HDL-C was a protective factor for HUA( P<0.001). Correspondence analysis showed that during the gradual increase of UA, TC was the first to appear abnormal, followed by hypertension and TG, and the increase of Cr appeared last. Mediating effect showed that in changes of UA, the mediating effects of MBP on TC, TG, and HDL-C were 36.35%, 12.63%, and 9.41%, respectively. In changes of eGFR, the mediating effects of MBP on TC, TG and HDL-C were 30.20%, 27.70%, and 6.13%, respectively. Conclusions:UA is positively correlated with blood pressure, TC, and TG, and inversely with HDL-C. TC and TG have an impact on renal impairment, in which MBP plays a mediating role.
ABSTRACT
Objective To observe the effect of different concentration sodium bicarbonate gastric lavage on newborn with swallow syndrome.Methods 88 patients from our hospital were enrolled in this study.They were randomly divided into control group (A group) and experimental groups(B、C、D、E group) according to numerical table.Separately using water and 1.0%, 1.5%, 2.0%, 2.5% sodium bicarbonate solution gastric lavage.Vomiting, abdominal distention, gastric retention and weight changes was observed.Results The result showed that the vomiting, abdominal distention, gastric retention of patients in experimental group were better than that of patients in control group, and there were significant differences between them(p0.05).And there were no significant difference among experimental and control groups in weight changes(p>0.05).Conclusion 1%sodium bicarbonate can much shorten the time to stop vomit and reduce complication.Therefore it is highly recommended and popularized.