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Journal of Chinese Physician ; (12): 1197-1199, 2011.
Article in Chinese | WPRIM | ID: wpr-422483

ABSTRACT

Objective To investigate the.expression and significance of peritoneal fluid (PF) erythropoietin (EPO) and neutrophils activation peptide-78 (ENA-78)in patients with endometriosis.Methods The levels of EPO and ENA-78 in peritoneal fluid (PF) were measured by means of enzymelinked immunosobent assay (ELISA) in 30 women with endometriosis (9 in Ⅰ ~ Ⅱ stage,21 in Ⅲ~ Ⅳ stage)and 30 without endometriosis.And the relationship between the PF levels of EPO and ENA-78 in patients with endometriosis was analyzed.Results The PF levels of EPO and ENA-78 in women with endometriosis [ (9.272 ± 2.284 ) IU/L,( 2.068 ± 0.794 ) ng/ml ] were significantly higher than those in control group [ (5.759 ±0.502) IU/L,(0.886 ±0.145 ) ng/ml,P <0.05].There were no significant differences in the PF levels of EPO between stage Ⅰ ~ Ⅱ [ (9.549 ± 1.996) IU/L] and Ⅲ ~ Ⅳ [ (9.181 ± 1.897) IU/L,P >0.05].The ENA-78 concentrations of PF in stage Ⅲ~ Ⅳ [ (2.517 ± 0.518 )ng/ml] were significantly higher than those in stage Ⅰ ~ Ⅱ[ ( 1.137 ±0.169)ng/ml,P <0.05].There were no obvious correlations in PF EPO and ENA-78 in patients with endometriosis.Conclusions The excessive expression of EPO and ENA-78 in the PF of women with endometriosis suggests that EPO and ENA-78 may be an important role in the pathogenesis of endometriosis.

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