RNase F and 2',5'-oligoA synthetase activities in mice after poly(I). poly(C) administration.

The present study demonstrates the presence of considerable levels of 2',5'-oligoA synthetase activity in tissue extracts from mice. The interferon inducer, poly(I).poly(C), induced the synthetase activity in all the tissue extracts in vivo. Similarly, a significant amount of endonuclease RNase F activity is found to be present in these tissue extracts. But interferon induction does not seem to have any significant effect on RNase F activity.