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Journal of Veterinary Science ; : 495-502, 2014.
Article in English | WPRIM | ID: wpr-24551

ABSTRACT

The purpose of this study was to investigate the genetic features of canine coronavirus (CCV) strains detected in Korea. M gene sequences obtained for isolates from 22 dogs with enteritis over a 5-year period were evaluated. Sequence comparison revealed that the 22 Korean CCV strains had an 87.2 to 100% nucleotide homology. Comparing to the typical reference CCV strains (type II), the nucleotide sequence of Korean strains had homology ranged from 86.3% to 98.3% (89.1% to 99.2% for the amino acid sequence) and 87.7% to 97.8% (92.4% to 100% for the amino acid sequence) when compared to FCoV-like CCV strains (type I). Three amino acid variations in the M gene were characteristic for the Korean CCV strains. Phylogenetic analysis demonstrated that the 22 Korean CCV strains belonged to four typical CCV clusters (i.e., a unique Korean CCV cluster, a type II and transmissible gastroenteritis virus cluster, an intermediate cluster between type I and II, and a type I cluster). This study was the first to identify genetic differences of the M gene from Korean CCV strains and provided a platform for molecular identification of different Korean CCV strains.


Subject(s)
Animals , Dogs , Female , Male , Amino Acid Sequence , Coronavirus Infections/epidemiology , Coronavirus, Canine/isolation & purification , Dog Diseases/epidemiology , Molecular Sequence Data , Phylogeny , Polymerase Chain Reaction/veterinary , Republic of Korea/epidemiology , Reverse Transcriptase Polymerase Chain Reaction/veterinary , Viral Matrix Proteins/genetics
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