ABSTRACT
Abstract Trichilia catigua A. Juss., Meliaceae, known as "catuaba" in Brazil, has been popularly used as a tonic for fatigue, impotence and memory deficits. Previously, we have demonstrated that T. catigua ethyl-acetate fraction exerted antidepressive-like effects in mice. Affective-like symptoms are also well recognized outcome of cerebral ischemia in clinical and preclinical settings. Therefore, here we evaluated the effects of ethyl-acetate fraction on the emotional outcomes and its relation with hippocampal neurogenesis in ischemic mice. Male Swiss mice were subject to the bilateral common carotid occlusion during 20 min. The animals received ethyl-acetate fraction (400 mg/kg, orally) 30 min before and once per day during 7 days after reperfusion. Emotional outcomes were assessed using the open field test, elevated zero maze, and the tail suspension test. After the behavioral testing, the animals were sacrificed and their brains were processed to immunohistochemistry and Nissl staining. Ischemic mice exhibited anxiogenic-like behaviors in the elevated zero maze, hippocampal neurodegeneration and decreased hippocampal neurogenesis. The anxiogenic-like effect was counteracted by ethyl-acetate fraction administration. Furthermore, ethyl-acetate fraction restored the number of newborn neurons in the dentate gyrus of hippocampus of ischemic mice. In conclusion, T. catigua ethyl-acetate fraction promoted functional recovery and restored hippocampal neurogenesis in ischemic mice.
ABSTRACT
O segmento populacional de idosos cresceu nas últimas décadas. Constatou-se isso em um asilo em Itajaí/SC, despertando assim o desejo de verificar a percepção dos cuidadores de enfermagem sobre a morte dos idosos...
Subject(s)
Aged , Humans , Attitude to Death , Death , Nursing, Team , Emotions , Caregivers , Homes for the Aged , Geriatric NursingABSTRACT
Uma das grandes dificuldades por que passa o Sistema Único de Saúde na questão assistencial, tem a ver com o crescente desinteresse dos Hospitais Filantrópicos de perfil regional em atender pacientes na Urgência-Emergência. Independente dos motivos que levaram a esta situação, a posição desses hospitais sobrecarrega as Unidades de Emergência dos Hospitais Universitários, com casos que muito provavelmente poderiam ser resolvidos no nível de referência local ou micro-regional. A partir desse diagnóstico, a Secretaria de Estado da Saúde propõe criar um Sistema organizado e regulado, para atender e garantir o acesso ao tratamento adequado, aos cidadãos que sofrem agravos agudos a sua saúde, sejam por causas externas, doenças agudas ou complicações de doenças crônicas pré-existentes (AU).