ABSTRACT
Background: Systemic vasculitis are a group of heterogeneous diseases characterized by inflammation and necrosis of blood vessel walls. The etiology is not known, but geographic and environmental factors are implicated. Aim: To describe the clinical features of microscopic polyangiitis (MPA) and Wegener's granulomatosis (WG) in a Chilean cohort of patients. Patients and methods: Retrospective review of the medical records of 123 patients with the diagnosis of systemic vasculitis (65 MPA and 58 WG), seen from 1990 to 2001. The diagnosis were made based on the American College of Rheumatology and Chapel Hill criteria. Results: The mean follow-up for MPA was 15 months (1-120) and for WG, 20 months (1-120). The median age (years) at diagnosis for MPA was 61 (19-82) and WG 50 (20-82). Gender distribution was similar in both groups (male: 68percent and 57percent respectively).The main clinical features in the MPA group were renal involvement (68percent), peripheral nervous system involvement (57percent), pulmonary hemorrhage (28percent), and skin disease (32percent). In the WG group were alveolar hemorrhage (62percent), renal involvement (78percent), paranasal sinus involvement (57percent), and ocular disease (26percent). In both, creatinine levels above 2.0 mg/dl were associated with a higher mortality (p< 0.01). ANCA by immunofluorescence was performed in 56 MPA patients (75percent had pANCA, 4percent had cANCA and 21percent were ANCA negative) and in 55 WG patients (17percent had pANCA, 79percent had cANCA and 4percent were ANCA negative). Global mortality was 18percent and 17percent respectively, and the most common causes of death were infections. Conclusions: The clinical features of our patients are similar to other published data. In our WG and MPA patients the main predictor for death was a serum creatinine above 2 mg/dl.
Subject(s)
Adult , Male , Humans , Female , Middle Aged , Granulomatosis with Polyangiitis/complications , Granulomatosis with Polyangiitis/immunology , Granulomatosis with Polyangiitis/pathology , Polyarteritis Nodosa/complications , Polyarteritis Nodosa/immunology , Polyarteritis Nodosa/pathology , Chile , Follow-Up StudiesABSTRACT
Background: The congruence of interests between health care providers and clients is essential if subjects with chronic diseases will be educated. Aim: To assess, in patients with rheumatoid arthritis, those fields in which they would like to receive education. Patients and methods: Eighty eight patients with rheumatoid arthritis were surveyed about the topics in whicb they would like to be educated. The inquiry included medical aspects, handicap overcoming, social issues and labor aspects. Results: Eighty two percent of Patients were interested in medical aspects, 77 percent in social issues and 71 percent in handicap overcoming. Eighty three percent of Patients with greater handicaps preferred handicap overcoming, 75 percent social aspects and 74 percent medical aspects. Younger patients had a greater interest in labor aspects, those with a recently diagnosed disease were interested in legal rights and those with a prolonged disease wanted information about self help groups. Conclusions: The greater educational interests of patients with rheumatoid arthritis were on medical aspects. However, those impaired by the disease were interested in handicap overcoming. Age and duration of the disease also influenced the educational interests of patients. Thus, education in these patients must be individualized