[Assessment of quality of life in patients with irritable bowel syndrome: a cross-sectional study in south-east Iran]

Background: Improving life is the main goal of therapeutic interventions for chronic diseases. Although we needed to determine quality of life by various variables. This study aimed to determine quality of life in patients with Irritable Bowel Syndrome [IBS] in Kerman

Materials and Methods: This is a cross sectional study of 143 patients with IBS referred to a specialist, assessed by IBS-QOL.34. Data analyzed by descriptive statistics, Pearson correlation coefficients, t-test and ANOVA, using SPSS software. p.Value <0.05 was considered as statistically significant

Results: In this study from 143 samples, 82 were females [57.3%] and 61 males [42.7%]. Quality of life score in patients was 37.16 +/- 16.72, and there was significant difference in terms of employment and education level [p.value<0.05]

Conclusion: Among patients with IBS, quality of life is far from desired. Therefore, health care providers should consider psychosocial support alongside medical management for achieving better quality of life in these patients

Small bowel bacterial overgrowth in patients with irritable bowel syndrome: the first study in Iran

Small intestinal bacterial overgrowth [SIBO] may have a role in the pathophysiology of irritable bowel syndrome [IBS]. So, the aim of this study was to assess the association between SIBO and IBS by using glucose breath test [GBT] in Kerman city as the first study in Iranian population. 107 patients with IBS and 107 healthy individuals were enrolled in our study. All the participants underwent GBT. A peak of H2 values >20 p.p.m above the basal value after glucose ingestion was considered suggestive of SIBO. SPSS software version 17 was used for data analysis. P value < 0.05 was considered as statistically significant. Of the 107 patients with IBS, 40 had positive GBT [37.4%] compared with 14[12.1%] out of the 107 control participants [p< 0.001]. Dominant symptoms in patients with IBS were diarrhea in 36[33.6%], constipation in 12[11.2%], abdominal pain in 22[20.6%], bloating in 28[26.2%], and change in bowel habit in 9[8.4%] patients. There was not statistically significant difference among any of this IBS subgroups and positive GBT [p=0.44]. There is a positive association between IBS and SIBO. We suggest a Placebo-controlled bacterial eradication study for identifying the role of SIBO in IBS

incidence rate of inflammatory bowel disease in an urban area of Iran: a developing country

The incidence of inflammatory bowel disease [IBD] varies among different societies. The aim of this study is to determine the incidence rate of IBD in Kerman, a city in Southeast Iran. All medical records that indicated a new diagnosis of ulcerative colitis [UC] or Crohn's disease [CD] were retrieved from the gastrointestinal endoscopy and pathology departments of 12 centers from October 2011 to September 2012. The incidence rate of UC in Kerman was estimated at 4.98/100,000 [95% CI: 2.44-6.94]. The mean age of patients was 39.4 years and male to female ratio was 0.89:1.0. UC patients had the following prevalence: cigarette smoking [30%], appendectomy [36%] and oral contraceptive [OCP] use [78.9%]. The incidence rate of CD was 0.8/100,000 [95% CI: 0.6 4-1.14]. The mean age at diagnosis was 33.3 years and male to female ratio was 0.5:1.0. Cigarette smoking was reported in 33.3%, appendectomy in 66.6% and OCP useing in 75% of CD patients. Rectal and distal colitis, left side colitis and extensive colitis was seen in 20 [55.4%], 12 [33.3%] and 4 [11.1%] of patients with UC, respectively. All patients with CD had large intestinal involvement and one case [16.6%] had ileocolonic disease. Our study has shown that the incidence rate of both UC and CD in Kerman is lower than Western populations but it is the same as some Asian countries. Characteristics of disease involvement in this study are similar to other studies that have been conducted in Iran and elsewhere.

[ assessment prevalence of functional constipation and associated factors in adults: a community-based study from Kerman, Southeast, Iran [2011-2012]]

Chronic constipation is a common problem worldwide that negatively impacts quality of life. Because of the effects of psychological and cultural factors on the function of the bowel tract and the vast variety of ethnicities and diet among the Iranian people, the present study describes the occurrence of constipation and its associated factors in Kerman, the largest city in Southeast Iran. This was a cross-sectional study conducted in Kerman, Iran from 2011 to 2012 that included 2191 adults who were randomly selected and interviewed face to face using a validated questionnaire based on Rome III criteria. Demographics, cigarette smoking, opium dependence, amount of fiber consumption, physical activity and psychological factors were assessed. Inclusion criteria was ages 15 to 85 years old. Exclusion criteria was the presence of any metabolic and/or neuro-muscular disease that caused constipation. All data were analyzed with Stata11 software, with a confidence interval of 95%. A p-value of 0.2]. Although the prevalance of constipation in Iran is estimated to be lower than Western countries, new changes in life style can cause an increase in the burden of constipation in the future

Blue Rubber Bleb Nevus Syndrome as a rare cause of iron deficiency anemia: a case report and review of literature

Blue Rubber Bleb Nevus Syndrome is a rare disorder that is characterized by multiple recurrent vascular malformations of skin and gastrointestinal tract. The affected patients may present with diverse manifestations including iron deficiency anemia. We report this syndrome in a 22-year-old man that was referred to our hospital for iron deficiency anemia with unknown cause and vascular malformations in the skin and gastrointestinal tract. Because of stable hemoglobin level, we decided to treatment him by iron supplementation and close follow up. We report this case along with a review of literature

Detection of A2142C, A2142G, and A2143G mutations in 23s rRNA gene conferring resistance to clarithromycin among Helicobacter pylori isolates in Kerman, Iran

Clarithromycin resistance in Helicbacter pylori has been found to be associated with point mutations in 23s rRNA gene leads to reduced affinity of the antibiotic to its ribosomal target or changing the site of methylation. The aim of this study was to determine the most important point mutations in 23s rRNA gene in H. pylori that are closely related to clarithromycin resistance among such isolates. Sixty three H. pylori isolates, obtained from gastric biopsy speciemens in Kerman, Iran, were used to evaluate their susceptibility to clarithromycin by disk diffusion test, and to detect the most common point mutations in 23s rRNA gene associated with clarithromycin resistance by Polymerase chain reaction-amplification and restriction fragment length polymorphism [PCR-RFLP] and 3'-mismatch PCR. 31.7% of the H. pylori isolates were resistant to clarithromycin, and each of the resistant isolate had at least one of the most common point mutations in 23s rRNA gene associated with calrithromycin resistance. According to our results three common point mutation in 23s rRNA gene in H. pylori are closely related to clarithromycin resistance. There was an absolute relation between 23s rRNA gene point mutations and clarithromycin resistance in this study. Helicbacter pylori resistance to clarithromycin can cause failure in the eradications of the bacteria. The resistance of the bacteria is expanding in most parts of the world including Iran