ABSTRACT
Parasitic infections can seriously affect child development and cognition while the treatment is easy and cheap. To elucidate apolipoprotein [ApoE] and neurodevelopment in children with Giardiasis and the role of ApoE isoforms in childhood cognition and infant development. The present study was performed on 75 Giardia-infected patients [1-9 years] and 45 healthy children control group of similar age and sex.They were subjected to anthropometric measurements. cognitive functioning. developmental assessments and determination of ApoE allelic forms. ApoE genotypes frequency distribution in the studied children was 6. 8, 4, 42, 27 and 33 for E2/2, E2/3. E2/4, E3/3. E3/4 and [4/4, respectively. There were no significant differences regarding demographic and anthropometric measurements as well as cognitive function between ApoE4 carrier and non carrier in children above 4 years; but their scores of performance, part of the intelligence test, and of the frill scale IQs proved to be at the lower normal level. Meanwhile, highly significant differences were observed between ApoE4 carrier and minim carrier regarding developmental assay in children below 4 years. The ApoE4 isoforms have a protective role on cognitive development in children below 4 years sufferring from sole Giartia infection. So, children with ApoE4 negative genotypes should be notified for their susceptibility to cognitive impairment after diarrhea in early infancy and childhood and are advised for careful follow up
ABSTRACT
A cross-sectional survey was conducted to monitor and compare the prevalence of helminthes in rodents from Dakahlia and Menoufia governorates. The domestic rodents [271] were Rattus norvegicus, Rattus rattus frugivorous, Rattus r. alexandrinus, and Mus musculus. The overall prevalence of helminthes was 52.8%. In Dakahlia, 72/145 rats [49.6%] were infected. The highest prevalence of infection was in R. r. frugivorous 43 [60.4%], then R. r. alexandrinus 44 [47.7%], R. norvegicus 38 [44.7%], and the lowest was M. musculus 20 [40%]. In Menoufia, 71/126 rats [56.3%] were infected. The highest prevalence of infection was in R, r. frugivorous 36 [77.7%], then M. musculus 27 [48.1%], R. norvegicus 23 [47.8%], and the lowest was in R. r. alexandrinus 40 [47.5%]. A total of 24 species of helminthes [11 trem-atodes, 4 cestodes and 10 nematodes] were identified among the 271 rodents. The commonest trematode was Mesostephanus aegypticus followed by Stictodora tridactyla. The commonest cestode was Hym-enolepis diminuta followed by Taenia taeniaformis. The commonest nematode was Capillaria hepatica followed by Trichurus muris. Given the zoonotic potential of rodents' parasites and since several residential, commercial, and agricultural sites exist in the examined geographic areas, the potential health risk should not be ignored