Histological prenatal studies on the development of human glenoid labrum

In this work, histological studies were done on transverse sections from thewhole posterior part of human glenoid labra in different chosen prenatal agesand adult age. In eight weeks old fetus, the glenoid labrum was a primitivemesenchymal cellular structure. At 16 weeks old fetus, it becamefibrocellular structure. From 23 weeks old fetus, the migration of cartilagetissue from the articular cartilage of glenoid fossa to the glenoid margin ofthe labrum resulted from the beginning of fibrocartilaginous appearance of the glenoid labrum. At full term, the area near to the glenoidmargin was highly cellular, while the area near to the free margin was morefibrous. In this work, although the glenoid labrum was highly vascularizedthroughout the prenatal life, the adult labrum was not vascularized at all. The collagen fibers were detected early in the glenoid labrum with subsequentincrease in their content during the prenatal life and extended to the adultlife. In contrast, the elastic fibers appeared rare in the full term andadult labra

Cardiovascular effects of anloxone [experimental evaluation]

This work is an evaluation of possible haemodynamic effects of naloxone. The work was done on isolated perfused heart of rabbit, blood vessels of isolated rat hind limb and anaesthetized dogs. Injection of naloxone in concentration of 1 and 2 ug/ml increased force of myocardial conractility of rabbit's heart, while higher concentration of 4 ug/ml produced arrhythmia. Experiments on perfused blood vessels of isolated rat hind limb demonstrated that naloxone produced no effect on peripheral vascular resistance. While experiments on anaesthetized dogs showed that naloxone in a dose of 10 ug/kg produced significant increase in mean arterial blood pressure [P < 0.05] with no change in heart rate. Injection of naloxone in doses of 20 ug/kg and 40 ug/kg produced different types of ventricular arrhythmias. The increase in blood pressure following naloxone was produced primarily by an improvement in myocardial contractility