Synthesis of coumarian derivatives of expected B-adrenergic blocking activity

The synthesis and structure activity relationships of a number of new synthesized coumarins, derived from 6- and 7-hydroxycoumarins are described. The structure of the obtained new products is confirmed by elemental analyses, i.r. and 1H-n-m.r. 7-Novel compounds were evaluated for B-adrenergic blocking and antihistaminic activities and the results are reported