ABSTRACT
Advanced glycation endproducts [AGEs] which accumulate in diabetic vasculature results in enhanced expression of endothelial cell associated vascular cell adhesion molecule-1 [VCAM-1] as well as release of soluble form of VCAM-1 [s.VCAM-1] into culture supernatant. The present work was designed to study plasma s.VCAM-1 concentration in diabetic patients and its relation to microalbuminuria, to study the hypothesis that s.VCAM-1 in diabetic plasma might reflect early vascular perturbation in diabetic vasculopathy. Diabetic patients with microalbuminuria [patients at risk for vascular complication] had increased s.VCAM-1 when compared to diabetic patients without microalbuminuria [p < 0.05] and when compared to control [p < 0.05]. In conclusion, s.VCAM-1 can serve as a marker of ongoing vascular perturbation in diabetic patients and it may be of potential benefit in the assessment of success of therapeutic intervention intended to minimize vascular injury
Subject(s)
Humans , Male , Female , Endothelium, Vascular , Biomarkers , Disease Progression , Albuminuria , Lipoproteins, HDL , Lipoproteins, LDL , Cholesterol , Triglycerides , Vascular Cell Adhesion Molecule-1/bloodABSTRACT
Variations in the level of scores and reaction patterns of the acid phosphatase [APh] activity were estimated in blood films of 60 patients with various hematologic disorders and 30 normal controls using the azo-dye method of Goldberg and Barka [1962] with some modifications. The percentage of lymphocytes showing dot-like APh. Positivity was high in disseminated lymphoblastic lymphoma [T cell pattern], but low in acute and chronic lymphatic leukaemia [Non T pattern]. These findings are considered an additional proof to the validity of APh. As a cytochemical marker for the recognition of T-lymphocytes in malignant lymphoproliferative disorders. Also, our study showed that APh. May be helpful in the detection of remission in malignant lymphoma. Neutrophil APh. Activity is increased in malignant lympho-proliferative disorders, myeloproliferative disease, bacterial infection and leukaemoid reaction