Pharmacokinetics of cefazolin and chloramphenicol in nephrotic syndrome among children

The antibacterial levels of Cefazolin and of Chloramphenicol were assayed microbiologically in the serum and urine of children suffering from nephrotic syndrome. Twenty five children suffering from nephrosis with equal number of normals as control of same sex were the subject of this study. The bioavailability of Cefazolin after parenteral route was found to be higher in corticosteroid resistant nephrotic syndrome with parallel lowering of urinary concentrations, while in corticosteroid sensitive nephrotics no variations from normal were noticed. Study of chloramphenicol levels in serum and urine did not show significant change from normal. The possible mechanism of these changes is discussed