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Background:An unknown pneumonia broke out in Wuhan City in December 2019 and it was confirmed as an acute respiratory infectious disease caused by Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2, formerly known as 2019-nCoV). Consumption coagulopathy, which should be obviated in order to decrease mortality, arises in disseminated intravascular coagulation with a decrease in fibrinogen and an increase in D-dimer levels. However, studies on the predictive and prognostic values of coagulation parameters in the setting of patients with COVID-19 are still limited. The objectiveof this retrospective study was to investigate the correlation of D-dimer and computed tomography severity score in patients with COVID-19 pneumonia.Methods:The present retrospective study was conducted among 108 subjects reported COVID RT-PCR positive admitted during the study period i.e.;January-August 2021 in the department of medicine of Rural Medical College, Loni. Pneumonia was confirmed by Computed tomography (CT) examination and coagulation test completed within 12 hr after admission were enrolled. Coagulation tests, which Fibrinogen (Fib) and D-dimer were performed. CTscore was categorized into mild (0-7), moderate (8-16) and advanced grade (17-25 points).Results:The mean age of male and female was 38.52�34 and 35.67�22 years respectively, with an overall age of 37.79�58 years. Mean D-dimer level was 0.54�09, 0.91�22 and 1.96�47 mcg/ml among subjects having mild, moderate and severe CT score respectively. According to multivariate analysis, higher D-dimer (OR:3.61, p<0.01) was significantly associated with CTseverity score.Conclusions:Study concluded that the D-dimer level's time point was matched to the time of CTscan, we have reasons to correlate that the D-dimer level may predict the severity of inflammation prior to coagulopathy/thrombosis
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Background: The global incidence of dengue has grown dramatically in recent decade. Half of world’s population is now at risk. India represents significantly a larger burden, accounting for nearly 34% of the global burden of dengue infection. Dengue infection needs to be addressed as a single disease with different clinical presentations ranging from asymptomatic conditions to severe clinical courses that may lead to high morbidity and mortality.Method: This was retrospective observational study carried out during period of July 2017 to April 2018, to study clinical profile and laboratory parameters in dengue fever patients. Confirmed dengue cases having NS1 positive or IgM positive or having both NS1 and IgM positive or dengue ELISA reactive, having minimum one CBC reports done and not having other confounding factor such as co-infection, bone marrow diseases etc. that may altered clinical and laboratory results are included in study. Statistical analysis was done by SPSS software version 18.0.Results: Out of 48 confirmed dengue cases maximum patients 58.33% was from young age group (21 to 40 years) with M:F ratio was 2.43:1. Fever was found in 100% patients, in order of frequency followed by headache, bodyache, abdominal pain, weakness, retro-orbital pain, anorexia, dry cough, back pain, nausea, diarrhoea, vomiting, rash, joint pain, itching and malena.NS1was positive in 41.67% cases, dengue ELISA in 31.25%, IgM was positive in 20.83% cases, and both NS1 and IgM positive were in 4.17% cases. TLC count was low 35.42%, high in 12.50% of cases and remaining had normal TLC count. Platelet count was ranged between normal platelet counts to thrombocytopenia. One case had platelet count less than 20000. Out of 48 patients, 2 (4.17%) had malena.Conclusion: In this study, fever was found in all patients, and headache, body ache and weakness were common symptoms, but significant number of patients also had gastroentstinal and respiratory symptoms like abdominal pain, nausea, diarrhea, vomiting and dry cough. TLC count ranging from normal TLC, leukopenia to leucocytosis. Large number of patients had low platelet count that shows dengue fever had varied clinical presentation.
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Background: Diabetes has become a major health problem in India. Inadequate knowledge and training of frontline medical care givers like nursing staff, intern doctors and resident doctors may result in increase in both acute and chronic complications amongst diabetes patients. So, it results to high economic burden on family especially in rural parts of India. So, objective of this study was to assess knowledge about diabetes and its management amongst medical interns and nursing staff in tertiary care teaching hospital in Marathwada region of Maharashtra.Methods: This was a cross-sectional study conducted at IIMSR Medical College, Badnapur, Jalna, Maharashtra amongst 70 nursing staff and 70 medical interns by convenient sampling method during the period of June to August 2018. Knowledge on diabetes was assessed through 30 questions.Results: Knowledge related to diabetes and its management is assessed in 70 nursing staff and 70 medical interns using 50 item questionnaires. Out of 70 nursing staff mean knowledge score was 38.13 and out of 70 medical interns mean knowledge score was 40.17. Those nursing staff that had experience more than 5 years and positive family history of DM had significant greater knowledge than counterpart. There was no significant difference in knowledge level in gender, age, degree or diploma and whether in-service education opted or not amongst nursing staff. Amongst intern knowledge was more in those who had positive family history of DM. There was no significant difference in knowledge level in male and female interns.Conclusions: This study concluded that there was knowledge gap about diabetes and its management amongst frontline care givers like nursing staff as compared to medical interns suggesting requirement of additional training and educations amongst frontline health care providers.
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Background: The long QT syndrome (LQTS) is a disorder of myocardial repolarization characterized by a prolonged QT interval on the electrocardiogram (ECG). Hence the present study was aimed to determine prevalence of QT prolongation of the ECG and to assess its impact on outcomes in patients admitted in medical ICU of Noor Hospital of IIMSR Medical College, Badnapur, Jalna, Maharashtra, India.Methods: This prospective observational study was carried out during the period of October 2016 to March 2018, for assessment of prevalence of prolonged QTc at admission and its impact on outcomes in medical ICU. QTc calculated by bazett’s formula of >440 ms for males and >460 ms for females was considered as prolonged. Details of illness, clinical observations and laboratory parameters were also monitored.Results: The total 150 patients were studied and there was a high prevalence (32%) of prolonged QTc at admission to the ICU which reduced to 20.5% on day 3. Patients with prolonged QTc were found to be at high risk for adverse outcomes and their ICU and hospital stay was more.Conclusions: The study concluded that prolonged QTc is common in authors’ medical ICU at admission (32%). Patients with QTc prolongation were at higher risk for adverse outcomes and their ICU and hospital stay was more.