ABSTRACT
Hemorrhoidal disease is a prevalent anorectal condition which is generally not managed well with current pharmacologic interventions. However, in Iranian traditional medicine (ITM) there are numerous plants with hemorrhoid-healing properties. The present research assembled plants with hemorrhoid-healing properties in ITM; their related pharmacological effects, phytochemical constituents and mechanisms of action in the modern medicine were also gathered. For this purpose, leading ITM textbooks were searched for plants with hemorrhoid-healing effects. Further, in vitro, in vivo and clinical studies on the most cited species were considered using scientific databases. Studying ITM textbooks revealed 37 medicinal plants with hemorrhoid-healing effects. Among the mentioned herbal medicines, six species, including Allium ampeloprasum, Phyllanthus emblica, Aloe vera, Terminalia chebula, Vitis vinifera and Commiphora mukul, had the largest number of related pharmacological effects documented in scientific databases. These herbs from ITM should be considered as important resources for producing novel drugs for hemorrhoid treatment.
ABSTRACT
Malaria is the most serious parasitic disease and one of the oldest recorded diseases in the world. Because of the resistance of malaria parasites to current drugs, it is necessary to discover new antiplasmodial drugs. Traditional medicine is one of the important sources of new antiplasmodial drugs. In this study, twenty methanolic extracts from different parts of sixteen medicinal plants used in traditional medicine of Iran for the treatment of "Nobeh fever" and/ or fever were screened for in-vivo antiplasmodial activity against Plasmodium berghei and cytotoxic effect on Madin-Darby bovine kidney cells [MDBK]. Eleven species [55%] were found to have antiplasmodial activity. Methanolic extract from Rosa damascena Mill. reduced parasitemia by 57.7% compared to untreated control mice at intra-peritoneal [i.p.] injection doses of 10 mg/Kg per day for 4 days. This is the first report that mentioned in-vivo antiplasmodial activity of Rosa damascena Mill
Subject(s)
Animals, Laboratory , Antimalarials , Plants, Medicinal , Medicine, Traditional , Fever/drug therapy , Malaria , MiceABSTRACT
Malaria is a major international public health problem. Drug-resistant parasites have made treatment and control of malaria more difficult. Therefore, safe, affordable and effective new drugs are urgently needed. Traditional medicine is an important source for new drugs. Determining the ancient medicinal books was the first step of this study for finding malaria or disease that has symptoms like malaria. Then the plants that used to treat "Ghebbe Khalesseh fever" were listed. Finally, recent antimalarial researches were explored. About 31 plants were identified. Information from these resources is valuable for the selection of plants for antiplasmodial screening programs
Subject(s)
Herbal Medicine , Plants, Medicinal , Fever , Medicine, Traditional , History, Ancient , History of Medicine , PlasmodiumABSTRACT
Primary dysmenorrhea is a prevalent disorder and its unfavorable effects deteriorates the quality of life in many people across the world. Based on some evidence on the characteristics of fenugreek as a medical plant with anti-inflammatory and analgesic properties, this double-blind, randomized, placebo controlled trial was conducted. The main purpose of the study was to evaluate the effects of fenugreek seeds on the severity of primary dysmenorrhea among students. Unmarried Students were randomly assigned to two groups who received fenugreek [n=51] or placebo [n=50]. For the first 3 days of menstruation, 2-3 capsules containing fenugreek seed powder [900 mg] were given to the subjects three times daily for two consecutive menstrual cycles. Pain severity was evaluated using a visual analog scale and systemic symptoms were assessed using a multidimensional verbal scale. Pain severity at baseline did not differ significantly between the two groups. Pain severity was significantly reduced in both groups after the intervention; however, the fenugreek group experienced significantly larger pain reduction [p<0.001]. With respect to the duration of pain, there was no meaningful difference between the two cycles in the placebo group [p=0.07] but in the fenugreek group, the duration of pain decreased between the two cycles [p<0.001]. Systemic symptoms of dysmenorrhea [fatigue, headache, nausea, vomiting, lack of energy, syncope] decreased in the fenugreek seed group [p<0.05]. No side effects were reported in the fenugreek group. These data suggest that prescription of fenugreek seed powder during menstruation can reduce the severity of dysmenorrhea
ABSTRACT
A high performance liquid chromatography method was studied for determination of 18 p-glycyrrhetinic acid in Glycyrrhiza glabra L. [licorice] extract. The operating condition were C-18 reversed phase column [VP-ODS, [250x4.6 mm, 5 mm]] at room temperature, acetonitril/phosphoric acid [3/1] as mobile phase, at flow rate of 0.6ml/min [0-8min], 0.4ml/ min [8-20min] and UV detection at 230 nm. The recoveries were%99.60-%102.81 with relative standard deviation between%0.01-% 1.58. The relative standard deviation of the repeatability test was%2.96. The method is simple, rapid, safe, accurate, economical and useful for standardization of the licorice products