ABSTRACT
Aim of the work: This work aimed to study the biochemical and histopathological changes in the kidney of male albino rats post exposure to 6Gy of gamma radiation and the protective role of transplanted bone marrow cells against damage induced in rat's kidney by a chemical carcinogen
Materials and Methods: In this study, forty eight healthy and active male albino rats about 120 grams in body weight were used. The animals were housed in plastic cages under normal temperature, pressure, humidity and good ventilation conditions during the whole period of experimentation. The animals were fed on a standard pellet diet and water
Results: Exposure of rats to gamma-radiation caused a significant increase in kidney function tests, decreased significantly the antioxidants with numerous histopathological changes in the rat kidney tissue. These changes were ameliorated by bone marrow transplantation either after whole body gamma-irradiation and/or Fe-NTA treatment
Conclusion: Bone marrow transplantation either after whole body gamma-irradiation and/or Fe-NTA treatment restored the kidney functions and ameliorated the oxidative stress and antioxidants markers. The histopathological observations showed amelioration in the structure of the kidney cortex. So, BM transplantation exerts some curative effects on the function and histological structure of kidney cortex of rats exposed to gamma-irradiation and/or Fe-NTA treatment
ABSTRACT
Aim of work: this work aimed to study the biochemical and histopathological changes in the liver of male albino rats post exposure to 6Gy of gamma radiation and the possible protective effect of bone marrow [BM] transplantation on the liver tissues by a chemical carcinogen ferric nitrilotriacetate [Fe-NTA] or gamma- radiation in rats
Materials and methods: In this study, thirty six healthy and active male albino rats about 120 grams in body weight were used. The animals were housed in plastic cages under normal temperature, pressure, humidity and good ventilation conditions during the whole period of the experiment. The animals were fed on a standard pellet diet and water. Animals were categorized into six groups and served as the following groups: control, gamma irradiated[R], Fe-NTA, BM+R, BM + Fe-NTA and BM.+Fe-NTA+R
Results: the present results suggested that exposure to gamma-radiation or Fe-NTA induced a significantly disturbance in the liver functions and structure. They increased significantly the oxidative stress and decreased significantly the antioxidants tissues and they also increased necrotic and apoptotic cells in rat's liver tissue. Bone marrow transplantation either after whole body gamma-irradiation or Fe-NTA treatment restored the liver functions and structure. BT also ameliorated the oxidative stress and antioxidative markers. The histopathological observations recorded some amelioration in the apoptotic and necrotic evaluation in liver tissue