ABSTRACT
Cancer research is an attractive field in molecular biology and medicine. By applying large-scale tools such as advanced genomics and proteomics, cancer diagnosis and treatment have been improved greatly. Cancers of esophagus, gastric, and colon accounted for major health problem globally. Biomarker panel could bring out the accuracy for cancer evaluation tests as it can suggest a group of candidate molecules specified to particular malignancy in a way that distinguishing malignant tumors from benign, differentiating from other diseases, and identifying each stages with high specificity and sensitivity. In this review, a systematic search of unique protein markers reported by several proteomic literatures are classified in their specific cancer type group as novel panels for feasible accurate malignancy diagnosis and treatment. About thousands of introduced proteins were studied; however, a small number of them belonged to a specific kind of malignancy. In conclusion, despite the fact that combinatorial biomarkers appear to be hopeful, more evaluation of them is crucial to achieve the suitable biomarker panel for clinical application. This effort needs more investigations and researches for finding a specific and sensitive panel
ABSTRACT
There are several types of cancer, which cause millions of deaths worldwide every year. Many studies have confirmed that plants are adequate natural sources to be examined as anti-cancer drugs with fewer side effects than chemotherapy and radiotherapy. In this study the anti-cancer properties of Lavender aqueous extract on lymphocytes derived from patients with Hodgkin's lymphoma has been studied. In order to determine the cytotoxic effects of the extract on lymphocytes of patients in stages III and IV of Hodgkin's lymphoma and two different cell lines in the presence of different concentrations of aqueous extract of Lavender, MTT colorimetric assay and flow cytometry analysis were used. Findings indicated that Lavender inhibited cell proliferation in both lymphocytes and cell lines with different effects. The effective concentration of Lavender that decreased viability of Hodgkin's lymphoma cells below Lethal Concentration 50 [LC50] value was 100 micro g/ml and this was half of the therapeutic dose. In addition, apoptosis was the main mechanism the Hodgkin's lymphoma cell encountered when exposed to the aqueous extract of Lavender. Conclusion: This experiment proposes that aqueous Lavender extract can be regarded as a potential anti-cancer agent in future studies
Subject(s)
Humans , Plant Extracts , Hodgkin Disease , Lymphocytes , Cell Proliferation , Cell Line , CytotoxinsABSTRACT
Conceptualization for new findings is the main aim of science and technology development. Sometimes new concepts are pathfinders for science and starting fundamental revolutions in science. An important area in scientology or scientific studies is the concept and term field, so terminology and its effect on science and technology is one of the most important subjects in the last decade. Standardization in scientific terms [scientific term selection] is one of the strongest terminology methods. These methods break down the terms to their meaningful parts or use prevalent terms, which are common among people or use eponyms and abbreviation processes, and finds the appropriate equivalent for them. The word parts are prefixes, suffixes and stems. In medical sciences, terms are mostly originated from Latin stems, so this method could be extremely efficient in these fields. The terminology committee of Persian Academy studied the highly frequent prefixes, suffixes and stems to help the standardization of terminology in medical sciences. This research introduces methods of term selection, some approved terms and their Persian equivalents. Term selection for medical terms is not an obligatory rule, but is a proposal for meeting the researchers need to strength Persian language as a scientific language