ABSTRACT
Objectives: The efficacy of single oral dose KetorolacTromethamine, Tramadol and Placebo was evaluated in paincontrol after periodontal surgery.Materials and Methods: The study design is a split mouthstudy involving three quadrants of the same patient. 20patients requiring flap surgeries in at least three quadrantswere recorded. Patients were randomly divided into threegroups as per the medications given, either 10 mg ketorolac or50 mg tramadol or placebo tablets at least 30 minutes beforeadministration of local anesthesia (LA). The duration of surgeryfrom the time of incision to the placement of the last suture isrecorded. After the completion of the surgery, patients wereasked to rate their subjective operative pain intensity using avisual analog scale.Results: Differences were statistically significant in VAS scorebetween ketorolac and placebo, and tramadol and placebogroup. Comparison of sum of pain intensity showedsignificantly greater pain levels in the placebo than in theketorolac group and tramadol group.Conclusion: The results of this single-dose, parallel-group,and double blind placebo-controlled study showed that 10-mgketorolac and 50-mg tramadol administered immediately beforeperiodontal surgery was effective for better response by thepatient during the procedure. However, ketorolac and tramadolpremedication neither affected delayed pain levels, norpostoperative analgesic consumption.
ABSTRACT
Objective: Periodontal disease results the production ofdifferent enzymes that are released by epithelial orinflammatory cells. There are important enzymes associatedwith cellular alteration and cell death like: Lactatedehydrogenase (LDH), Creatine Kinase (CK), Alkaline andAcidic phosphatase (ALP, ACP). Enzymatic activity changesresults in changes health and metabolic changes in Gingivaland Periodontal condition.Design of study: We have examined the activity of CK, LDH,ALP and ACP in saliva from patients with periodontal diseasebefore and after periodontal treatment (experimental group –40samples) and in saliva from healthy patients (control group –30 samples). Periodontal disease was determined based onclinical parameters (gingival index (GI), bleeding on probing(BOP), probing depth (PD). Patients with periodontal diseasewere under periodontal treatment.Results: Results showed statistically significant increases ofactivity of CK, LDH, ALP and ACP in saliva from patients withperiodontal disease in relation to control group. There ispositive correlation between the examined salivary enzymesand value of the gingival index. After periodontal therapy theactivity of all salivary enzymes was significantly decreased.Conclusions: Based on these results, it can be stated thatactivity of these enzymes in saliva, as biochemical markers forperiodontal tissue damage, may be useful in diagnosis,prognosis and evaluation of therapy effects in periodontaldisease.