ABSTRACT
Background: In Indian societies womanhood is defined through motherhood and infertile women usually carry the blame for the couple’s inability to conceive. In many cases, the childless woman is made to feel inferior and may be abused or even tortured by the family. In India estimated infertility to be in the range of 4–6 %.Among all causes of female infertility, ovulatory dysfunction due to endocrinal abnormalities like, thyroid dysfunction and hyperprolactinemia are most common and most reversible (treatable) cause. Method: Hospital based study of thyroid dysfunction and prolactin level in infertile women a case control study. Hundred consecutive infertile women from Infertility clinic of OBGY department was enrolled and equal number of fertile women of reproductive age group, controls were taken from OBGY OPD. Result: Thyroid dysfunction (OR = 4.85, 95% CI = 2.39 – 9.81, P = 0.0001), Hyperprolactinemia (OR = 4.25, 95% CI = 1.82 – 9.92, P = 0.0004), Menstrual abnormalities (OR = 4.13, 95% CI = 2.12 – 8.02, P = 0.0001) were significantly associated with infertility. Difference between mean TSH values and mean prolactin level in cases and controls were found to be highly significant (p=0.0001). Conclusion:Thyroid dysfunction, hyperprolactinemia and menstrual abnormalitieswere significantly higher in infertile women as compared to the fertile women.There was weak positive correlation between hypothyroidism and hyperprolactinemia in infertile women.Routine screening of infertile women will facilitate early diagnosis and treatment of these two disorders which will certainly help in restoring fertility in these women.