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Objective To investigate the association of two functional polymorphisms of tryptophan hydroxylase 2(THP2) gene,rs4570625 and rs4565946,with poststroke anxiety disorders.Methods Totally 112 poststroke anxiety patients and 246 non-anxious stroke controls were included and completed Hamilton Anxiety Rating Scale.DNA was extracted from blood and genotyped for the two polymorphisms of THP2 gene by polymorphism chain reaction.Results The G allele of rs4570625 was associated with the increased risk of poststroke anxiety.Both the GG genotype and G allele were observed to be significantly higher in female case than in control.No significant difference in genotype and allele firequencies of the rs4565946 was found among the groups.Patients with the G-C haplotype had significantly increased the risk of poststroke anxiety compared to controls.Conclusions Our findings suggest that these ftmctional polymorphisms in TPH2 gene may be involved in development of poststroke anxiety.
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Objective To investigate the association between M235T polymorphism of angiotensinogen (AGT) gene and cerebral infarction(CI) in Chinese.Methods AGT gene M235T polymorphism was examined in 75 cases with CI and 48 healthy controls by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).Results The frequencies of AGT gene T235 allele and 235TT genetype were 0.78 and 0.64 respectively,compared with those of the control group (0.604 and 0.375 respectively ),the difference was significant(? 2=8.82, P
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Os cuidados intensivos no período pós-anestesico imediato tem como um dos objetivos detectar rapidamente alteraçöes que possam afetar a recuperaçäo normal do paciente e iniciar procemente o tratamento adequado. As Autoras relatam sua experiência no atendimento de 1791 pacientes que foram admitidos no Centro de Recuperaçäo Pós-Anestésica do Hospital Säo Paulo da Escola Paulista de Medicina no período de setembro a dezembro de 1988 e discutem as complicaçöes mais freqüentemente encontradas neste serviço. Além de descrever as características da unidade, as autoras ressaltam a importância de dispor de uma equipe de enfermagem treinada e de equipamentos adequados; recomendam o estabelecimento de rotinas de cuidados e controles e de registro de informaçöes relacionadas à evoluçäo dos pacientes