Effect of pregnancy-induced hypertension syndrome on complications in very low birth weight preterm infants / 中国当代儿科杂志

<p><b>OBJECTIVE</b>To study the effect of pregnancy-induced hypertension syndrome (PIH) on complications in very low birth weight (VLBW) preterm infants.</p><p><b>METHODS</b>The VLBW preterm infants were enrolled as research subjects, and according to the presence or absence of PIH in their mothers, they were divided into PIH group and non- PIH group. The incidence of major complications and length of hospital stay were compared between the two groups.</p><p><b>RESULTS</b>There were no significant differences between the two groups in gestational age, birth weight, sex, incidence rate of maternal diabetes, and use of antepartum hormone. The PIH group had a significantly higher rate of birth of small-for-gestational-age infants than the non-PIH group. The PIH group had a significantly lower incidence rate of bronchopulmonary dysplasia (BPD) than the non-PIH group, while there were no significant differences between the two groups in the incidence rates of apnea of prematurity, necrotizing enterocolitis, retinopathy of prematurity, and intraventricular hemorrhage-periventricular leukomalacia, and the length of hospital stay. There was no significant difference in the incidence rate of neonatal respiratory distress syndrome between the two groups, but the PIH group had a significantly lower proportion of infants who used pulmonary surfactant than the non-PIH group.</p><p><b>CONCLUSIONS</b>PIH can alleviate respiratory complications and reduce the use of pulmonary surfactant and the incidence rate of BPD in preterm infants.</p>

Effects of probiotics on feeding intolerance in low birth weight premature infants / 中国当代儿科杂志

<p><b>OBJECTIVE</b>To study the efficacy and safety of probiotics for the prevention of feeding intolerance in low birth weight (LBW) premature infants.</p><p><b>METHODS</b>Sixty eligible LBW premature infants were randomly divided into probiotics and conventional treatment groups (n=30 each). Both groups received treatment of the primary disease. Additionally, the probiotics treatment group was administered with probiotics (0.25 g, twice daily). The incidence of feeding intolerance, the time to regain birth weight and to reach full enteral nutrition and the length of hospitalization were compared between the two groups. The occurrence of adverse reactions was recorded.</p><p><b>RESULTS</b>The incidence of feeding intolerance in the probiotics treatment group was lower than that in the conventional treatment group (4% vs 14%; P<0.01). The time to regain birth weight (6.8±1.2 days vs 7.7±1.6 days; P<0.05) and the time to reach full enteral nutrition (8.0±1.4 days vs 9.0±2.0 days; P<0.05) in the probiotics treatment group were shorter than those in the conventional treatment group. No adverse reactions were observed in the probiotics treatment group.</p><p><b>CONCLUSIONS</b>Probiotics can reduce the incidence of feeding intolerance in LBW premature infants, can promote weight gain and shorten the time to reach full enteral nutrition. The application of probiotics appears to be safe in LBW premature infants.</p>