Study of the correlation of ET and CGRP in cough variant asthma patients / 中国综合临床

Objective To understand the levels of plasma endothelin (ET) and calcitonin gene-related peptide (CGRP) in cough variant asthma(CVA) patients, and to investigate their correlation and clinical implications. Methods Thirty CVA patients,30 typical bronchial asthma patients and 25 healthy controls were recruited. Three milliliter limosis venous blood were drawn from each patient to measure the levels of plasma ET and CGRP by radioimmanity. Results ①The levels of ET in the CVA group and typical bronchial asthma group were higher than that in healthy controls (P < 0.01). Their values were (103.58±28.66) ng/L, (129.37±27.28) ng/L and (72.63±21.52)ng/L, respectively. The levels of CGRP in the CVA group and typical bronchial asthma group were (7.62±2.56) ng/L and(6.63±2.09)ng/L The level of CGRP in the healthy controls group was (21.60±3.29) ng/L. The first two groups were lower than the latter(P < 0.01). However, there was no significant difference between the CVA group and typical bronchial asthma group(P >0.05). ②ET and CGRP were negatively correlated in both CVA group(r= -0.819,P<0.05) and typical bronchial asthma group(r= -0.738,P<0.05). Conclusions ET and CGRP were negatively correlated in both CVA group and typical bronchial asthma group, which means that ET and CGRP were a couple of antagonistic factors participated in the regulation of CVA, and may play an important role in the process of CVA.

Clinical observation on treatment of diabetic nephropathy with Huangqi Danggui Mixture / 中成药

AIM: To observe the effect of Huangqi Danggui Mixture on diabetic nephropathy. METHODS: Using Huangqi Danggui Mixture to treat 32 patients with diabetic nephropathy,In control group 22 patients were treated with Losartan.The therapeutic course was 3 months for both groups.The changes of clinical symptoms,blood glucose,lipid metabolism and urinary albumin were observed and compared. RESULTS: The total effective rate in the treated group was 80.9% while in the control group 63.3%.The symptoms,urinary protein and albumin as well as lipid metabolism in the treated group all significantly improved after treatment (P