ABSTRACT
Objective To discuss the clinical manifestations and the characteristics of spondyloarthritis (SPA) complicated with Turners syndrome,in order to promote the understanding of this disease.Methods A case of ankylosingspondylitis complicated with Turner syndrome in our department was re-ported,7 similar reports of SpA complicated with Turner syndrome in recent chinese and foreign literatures were reviewed.Their symptoms,signs,laboratory examinations etc were analyzed.Results All 8 cases were female,the median age when patients first their visited doctors was 25 (10 to 34 years old),7 of them showed peripheral arthritis,4 of them showed remarkable low back pain and limited motion of the spine,1 showed pain in hip area,3 showed varus or valgus joint deformity,5 combined with osteoporosis.There were 3 chromosome karyotypes:① 45,XO;② 45,XO/46,XX;③ 45X/46,X,psu,idic (X).Per treatment,6 patients received treatment with sulfasalazine tablets and non steroidal anti-inflammatory drugs,1 combined with methotrexate tablets,5 received calcium and vitamin D,1 received treatment with bisphosphonates.For the treatment of Turner syndrome,2 received estrogen replacement therapy,1 received growth hormone therapy.Conclusion The characteristics of SpA complicated with Turner syndrome are remarkable peripheral arthritis,prone to osteoporosis.For treatment we should give consideration to both of the 2 diseases,especially pay attention to the treatment of calcium and vitamin D.