PHARMACOKINETIC STUDY OF ZINC L-LYSINATE AND ZINC GLUCONATE IN RABBITS / 西安交通大学学报(医学版)

In this paper, the pharmacokinetic parametersof Zinc L-lysinate and Zinc Gluconate in rabbits arestudied by using the atomic absorption spectropho-tometry method. The results show that the serumconcentration-time curves of Zinc L-lysinate andZinc Gluconate in rabbit fit to one-compatmentmodel and a two-compartment model, respective-ly, The main pharmacokinetic parameters of ZincL-lysinate are: t_(1/2) (ke) 1. 01 h, T (p) 1. 08 h, andCI/F (s) 39. 63 1/kg. h; of Zinc Gluconate are: t_(1/2)(?) 9. 49h, T (p) 1. 3h, and Cl (s) 13. 14 1/kg. h.