A Over View to Diagnosis of Oral Lichen Planus: A Hospital Based Clinical Study

Objective: To evaluate the clinical characteristics,predisposing/aggravating factors and malignant potential oforal lichen planus (OLP).Study design: This study was conducted at department ofSkin & V.D., S. P. Medical College Bikaner at outpatient basis.Results: Reticular form was the most common clinical typeseen in 64 patients (54.7%), followed by erosive in 37 (32.6%)and erythematous types in 15 (12.6%) patients. The diseasecaused pain, burning and other symptoms in 72 (75.7%)patients. Buccal mucosa was the chief site of involvement(n=29). Other sites involved were tongue (n=8), lips (n=21),palate (n=3) and floor of mouth (n=0). Stress, spicy foods andpoor oral hygiene aggravated disease in most (n=77) of thepatients. A malignant transformation rate of 0.07% wasobserved.

Ulipristal Acetate: The Latest in Emergency Contraception.

Unintended pregnancy is a global reproductive health problem. Emergency contraception (EC) provides women with a safe means of preventing unwanted pregnancies following unprotected intercourse. Current gold standard emergency contraceptive is levonorgestrel (LNG) given within 72 hours of unprotected intercourse. Ulipristal acetate is a selective progesterone receptor modulator (SPRM) recently approved by US FDA for emergency contraception. It can be used upto five days (120 hours) after an unprotected intercourse and a single dose of 30 mg is effective.

Unresponsive cutaneous leishmaniasis and HIV co-infection: Report of three cases.

Cutaneous leishmaniasis (CL) is a vector borne disease caused by various species of Leishmania parasite. CL is endemic in the Thar desert of Rajasthan state and Himachal Pradesh in India. Immune suppression caused by human immunodeficiency virus (HIV) infection is associated with atypical clinical presentation of CL which responds poorly to the standard treatment and causes frequent relapses. We are reporting three cases of localized and disseminated CL due to Leishmania tropica which failed to respond to conventional intralesional/intramuscular sodium stibogluconate (SSG) injections. Initially, we did not think of HIV infection because CL is endemic in this region. When patients did not respond to SSG injections, we performed enzyme-linked immunosorbent assay (ELISA) tests for HIV and they turned out to be HIV positive. Our report showed that CL is emerging as an opportunistic infection associated with HIV/AIDS and may be the first manifestation in HIV positive patients in an endemic area.