ABSTRACT
Context: reproductive domains of the Tehran lipid and glucose study [TLGS] are unique in that they provide reliable information on reproduction of an urban population ofWest Asia. The aim of this review is to present the most important reproductive findings of TLGS
Evidence Acquisition: this review is summarizing all articles published in the context of reproductive aspects of TLGS results over the 20-year follow-up. A comprehensive databases search was conducted in PubMed [including Medline], Web of Science and Scopus for retrieving articles on the reproductive histories in context of the TLGS
Results: the mean [SD] age at menarche and menopause was 13 [1.2] and 49.6 [4.5] years respectively. While pills were the most commonly used modern methods at the initiation of TLGS, the prevalence of condoms rose sharply and significantly over the follow up duration. Among women with history of gestational diabetes, the risk of diabetes and dyslipidemia progression were 2.44 and 1.2 fold higher than others. Prevalences of PCOS and idiopathic hirsutism among reproductive age participants of TLGS were 8.5% [95% CI: 6.8% - 10.2%] and 13.0% [95% CI: 10.9% - 15.1%], respectively. Trend of cardio-metabolic risk factors among women with PCOS showed that there were no statistically significant differences between mean changes of each cardio metabolic variables between PCOS and healthy women; PCOS status also significantly associated with increased hazard of diabetes and prediabetes among women aged younger than 40 years [HR: 4.9; 95% CI: 2.5 - 9.3, P value < 0.001]] and [HR: 1.7; 95% CI: 1.1 - 2.6], P value < 0.005], respectively
Conclusions: the population based nature of TLGS provides a unique opportunity for valid assessment of reproductive issues, the results of which could provide new information for modification of existing guidelines
ABSTRACT
Background: Women engaged with polycystic ovarian syndrome [PCOS], as the commonest endocrine disorder, are known to have a specific type of adiposity. Birth weight is among different contributors reported to be responsible for this diversity
Objective: We aimed to compare the relation between birth weight and body fat mass [BFM]/ body lean mass [BLM] in PCOS and their age and body mass index [BMI] matched normal controls
Materials and Methods: In this case-control study, a total number of 70 reproductive aged women, diagnosed with PCOS and 70 age- BMI matched healthy women without hirsutism and/or ovulatory dysfunction were recruited., control group had no polycystic ovaries in ultrasonographic scans. A detailed history of birth weight was taken and was divided into the following categories: <2,500 [low birth weight, LBW] and 2,500-4,000 [normal birth weight; NBW]
Results: Results showed that LBW prevalence was higher in women with PCOS than in controls [19.3% [27] vs. 15.7% [22]]. Also body fat and lean mass [BFM, BLM] have increased in adult women with PCOS who were born underweight compared to their normal [19.8+/-9.05 vs. 12.9+/-4.5, p=0.001 and 48.9+/-6.9 vs. 43.2+/-5.8, p=0.004 respectively]
Conclusion: Fetal birth weight influences on the adulthood obesity, BFM and BLM. This impact is different among women with and without PCOS