ABSTRACT
Statement of the Problem: The expression of minichromosome maintenance-3 [MCM3] proteins and their diagnostic value in oral mucosal dysplasia and squamous cell carcinoma [SCC] is not well known.
Purpose: This study was conducted to evaluate the usefulness of minichromosome maintenance 3 [MCM3] as a biomarker for diagnosis of oral premalignant lesions and SCC.
Materials and Method: In this study, 31 oral SCC, 20 dysplastic epithelium and 20 controls were selected and immunohistochemical staining was done for MCM3. ANOVA, Tukey HSD, Mann-Whitney and Kruskal-Wallis tests were used to compare the groups and the correlation between different grades
Results: There was increasing trend of MCM3 from control to dysplastic epithelium and from dysplastic epithelium to SCC both in suprabasal layers and in total epithelial layers. MCM3 expression was elevated with increasing the grade of dysplasia, but there was no statistically significant difference [p= 0.93]. The expression was also increased in high grades of SCC compared to lower grades
Conclusion: MCM3 can be used as a useful biomarker in the diagnosis of premalignant lesions and oral SCC
ABSTRACT
Elastofibroma is a rare neoplasm that characteristically occurs in subscapular area in response to microtrauma. There are some reports of this tumor in other sites of the body but, up till now, there has been no report of elastofibroma in the face. A 20-year-old man presented with a slow growing painless mass in the face without any history of trauma. Histopathologic examination revealed a soft tissue mass composed of eosinophilic fibers admixed with aggregation of fat cells, capillary blood vessels, and fibroblasts. Elastic stain and Masson's trichrome stain confirmed the nature of elastic and collagen fibers. It was a case of elastofibroma in the face