Frenectomia lingual com laser de diodo de alta potência: relato de caso / Lingual frenectomy with high-power diode laser: a case report / Frenectomía lingual con láser de diodo de alta potencia: informe de un caso

Introdução: A laserterapia de alta potência tem estabelecido proporções satisfatórias na odontologia e se tornando a primeira opção de conduta cirúrgica para procedimentos, trazendo qualidade de vida aos pacientes e praticidade aos Cirurgiões. Objetivo: Relatar caso clínico de frenectomia lingual com uso do laser de diodo de alta potência ressaltando os benefícios da conduta. Relato de caso: Paciente sexo feminino, leucoderma, sem alterações sistêmicas, chega à Clínica Escola de Odontologia da Universidade Federal de Campina Grande, com queixa principal de alterações na sua fonologia. No exame intraoral observou-se dificuldade de movimentação lingual e em formato de coração devido a inserção fibrosa do freio, sendo observado a Anquiloglossia. Após explicações da alteração, do tratamento, e assinatura do Termo de Consentimento, foi iniciado a cirurgia: antissepsia, anestesia com vasoconstrictor, e em modo contínuo utilizou-se o laser de diodo de alta potência (TW Surgical- MMO®) configurado em 2W de potência, fibra 600µm, no comprimento de onda infravermelho, de modo que as fibras fossem separadas uniformemente e promovesse mobilidade imediata da língua, por fim realizou-se uma sutura em ponto simples com fio reabsorvível. Para o pós-operatório foi prescrito Dipirona em caso de dor, e estabelecido o acompanhamento. No retorno de 7 dias observou-se cicatrização normal e não ingestão do medicamento, em 30 dias foi visto a completa cicatrização e mobilidade sem desconforto, além de relato da paciente de melhoria na condição de relacionamentos sociais, autoestima e deglutição. Conclusão: O resultado apresentado neste artigo ratifica a benefício da escolha do laser em comparação ao convencional, demonstrando que não há sangramento no trans e pós cirúrgico, além de favorecer o processo de reparação tecidual, da redução do tempo cirúrgico, aumento do conforto, e diminuição de uso de medicamento, desta forma associando o laser cirúrgico a melhoria da qualidade de vida.

Introduction: High-power laser therapy has established satisfactory proportions in dentistry and has become the first choice for surgical procedures, bringing quality of life to patients and convenience to surgeons. Objective: To report a clinical case of lingual frenectomy using high-power diode laser, highlighting the benefits of this approach. Case report: A female patient, leucoderma, without systemic alterations, arrived at the Dental School Clinic of the Federal University of Campina Grande with the main complaint of alterations in her phonology. In the intraoral examination, difficulty in lingual movement and a heart-shaped tongue due to fibrous insertion of the frenum were observed, indicating Ankyloglossia. After explanations of the condition, treatment, and signing of the Informed Consent Form, the surgery was initiated: antisepsis, anesthesia with vasoconstrictor, and continuous mode using a high-power diode laser configured at 2W of power, 600µm fiber, at an infrared wavelength, with the aim of uniformly separating the fibers and promoting immediate tongue mobility. Finally, a simple suture was performed using absorbable thread. For the postoperative period, Dipyrone was prescribed for pain relief, and follow-up was established. At the 7-day follow-up, normal healing was observed, and the patient did not require the medication. At 30 days, complete healing and discomfort-free mobility were observed, along with the patient's testimony of improvement in social relationships, self-esteem, and swallowing. Conclusion: The results presented in this article confirm the benefits of choosing laser therapy over conventional methods, demonstrating the absence of bleeding during and after surgery, promoting tissue repair, reducing surgical time, increasing comfort, and decreasing the use of medication. Therefore, the use of surgical laser is associated with an improvement in quality of life.

Introducción: La terapia láser de alta potencia se ha establecido en proporciones satisfactorias en odontología y se ha convertido en la primera elección para procedimientos quirúrgicos, aportando calidad de vida a los pacientes y practicidad a los cirujanos. Objetivo: Relatar un caso clínico de frenectomía lingual con láser de diodo de alta potencia, destacando los beneficios de este procedimiento. Relato del caso: Paciente del sexo femenino, leucoderma, sin alteraciones sistémicas, llegó a la Clínica de la Facultad de Odontología de la Universidad Federal de Campina Grande con la queja principal de alteraciones en su fonología. El examen intraoral reveló dificultad en el movimiento lingual y lengua en forma de corazón debido a la inserción fibrosa del freno, observándose anquiloglosia. Tras explicar la alteración, el tratamiento y firmar el consentimiento, se inició la cirugía: antisepsia, anestesia con vasoconstrictor y uso continuado de un láser de diodo de alta potencia (TW Surgical- MMO®) configurado a 2W de potencia, fibra de 600µm, a longitud de onda infrarroja, para que las fibras se separaran uniformemente y favorecieran la movilidad inmediata de la lengua, y finalmente una sutura de punto único con hilo reabsorbible. En el postoperatorio, se prescribió dipirona en caso de dolor y se estableció un seguimiento. En el seguimiento a los 7 días, se observó una cicatrización normal y no se tomó medicación. A los 30 días, se observó una cicatrización completa y movilidad sin molestias, así como el informe del paciente de una mejora de las relaciones sociales, la autoestima y la deglución. Conclusión: Los resultados presentados en este artículo confirman el beneficio de la elección del láser frente a la cirugía convencional, demostrando que no hay sangrado durante ni después de la cirugía, además de favorecer el proceso de reparación tisular, reducir el tiempo quirúrgico, aumentar el confort y reducir el uso de medicación, asociando así el láser quirúrgico a una mejor calidad de vida.

Evaluation of the efficacy and safety of cannabidiol-rich cannabis extract in children with autism spectrum disorder: randomized, double-blind, and placebo-controlled clinical trial

Abstract Objective Autism spectrum disorder (ASD) is characterized by persistent deficits in social communication and social interaction and by restricted and repetitive patterns of behavior. Some studies have shown that substances derived from Cannabis sativa improve the quality of life of children with ASD without causing serious adverse effects, thus providing an alternative therapeutic option. The objective of this study was to evaluate the efficacy and safety of a cannabis extract rich in cannabidiol (CBD) in children with ASD. Methods In this randomized, double-blind, placebo-controlled clinical trial, 60 children, aged from 5 to 11 years, were selected and divided into two groups: the treatment group, which received the CBD-rich cannabis extract, and the control group, which received the placebo. They both used their respective products for a period of 12 weeks. Statistical analysis was done by two-factor mixed analysis of variance (two-way ANOVA). Results Significant results were found for social interaction (F1,116 = 14.13, p = 0.0002), anxiety (F1,116 = 5.99, p = 0.016), psychomotor agitation (F1,116 = 9.22, p = 0.003), number of meals a day (F1,116 = 4.11, p = 0.04), and concentration (F1,48 = 6.75, p = 0.01), the last of which was only significant in mild ASD cases. Regarding safety, it was found that only three children in the treatment group (9.7%) had adverse effects, namely dizziness, insomnia, colic, and weight gain. Conclusion CBD-rich cannabis extract was found to improve one of the diagnostic criteria for ASD (social interaction), as well as features that often co-exist with ASD, and to have few serious adverse effects.

Transtorno de uso de internet entre graduandos de Medicina no primeiro ano da pandemia de Covid-19 / Internet addiction disorder among medicine students in the first year of the covid-19 pandemic

Resumo: Introdução: Apesar das facilidades proporcionadas pela internet, seu uso inadequado e excessivo pode gerar Transtorno de Uso de Internet, principalmente entre os universitários que a utilizam para entretenimento, comunicação e atividades acadêmicas, como ocorreu durante a pandemia de Covid-19, quando o ensino ficou on-line. Esse transtorno culmina em prejuízos, como a redução no desempenho estudantil e a exacerbação ou o aparecimento de doenças psiquiátricas. Objetivo: Este estudo teve como objetivo avaliar a presença do transtorno de uso de internet entre estudantes de Medicina em universidades do estado de Alagoas, Brasil. Método: Trata-se de um estudo quantitativo, transversal e analítico realizado com estudantes de Medicina de duas instituições de ensino superior do estado de Alagoas durante o primeiro ano de pandemia de Covid-19. A coleta foi feita por um instrumento on-line com uma avaliação sociodemográfica, o Teste de Dependência de Internet e as variáveis sexo, idade, período, cidade de origem e coeficiente acadêmico de rendimento. Os dados foram analisados nos programas SPSS 24 e JASP 0.14. Resultado: Participaram da pesquisa 325 estudantes, dos quais 97,2% afirmaram ter aumentado o consumo da internet durante o período da pandemia. A média de pontuação no teste foi de 32,5, no qual 80,6% apresentaram algum grau de transtorno de uso de internet, sendo 66,8% leve e 13,8% moderado. Constatou-se maior prevalência da dependência no sexo masculino, com achado entre eles de criar novas amizades pela internet, de ocultar revelar o que faz on-line e gastar mais tempo que o planejado navegando. Houve maior gravidade de compulsão nos estudantes de classes sociais mais baixas, em períodos iniciais do curso, provenientes de instituição pública, oriundos de cidades com até 50 mil habitantes e nos imigrantes. Houve uma relação negativa significativa entre menor coeficiente do último período cursado e maior nota no teste (Pearson -0,121, valor de p: 0,045). Conclusão: Os dados apontaram que os estudantes de Medicina estão propensos a desenvolver transtorno de uso de internet e que houve maior gravidade entre o sexo masculino, em classes sociais mais baixas, nos períodos iniciais do curso, nos procedentes de instituição pública, de cidades com até 50 mil habitantes e nos imigrantes. A presença do transtorno foi inversamente proporcional à performance acadêmica.

Abstract: Introduction: Although the internet provides various facilities, its inadequate and excessive use can cause Internet Addiction Disorder, especially among university students, who browse the web for entertainment, communication and academic activities, and even more so during the COVID-19 pandemic, when education switched to online. This disorder results in several detrimental consequences such as diminished student performance and aggravation or triggering of other psychiatric conditions. Objective: To evaluate the presence of Internet Addiction Disorder in medical students at the state of Alagoas, Brazil. Methods: Quantitative, cross-sectional and analytic study conducted among medical students from two universities in the state of Alagoas during the first year of the COVID-19 pandemic. The data was gathered through an online form with a social-demographic questionnaire, the Internet Addiction Test, and variables (sex, age, semester of study, city of birth, grade point average). The data was analysed in the SPSS 24 and JASP 0.14 programs. Results: The survey was applied to 325 students, 97.2% of whom affirmed to have increased their internet usage during the pandemic. The average score in the Internet Addiction Test was 32.5, with 80.6% displaying some degree of disorder, 66.8% a mild dependence, and 13.8% moderate dependence. A higher prevalence of the disorder was found among males, who were also shown to be more used to making new friendships through the internet, to hide what they are doing online, and to spend more time logged in than planned. The compulsion was more severe in lower social classes, initial semester and those who came from public university, cities with a population of less than 50.000, and immigrants. There was a negative correlation between lower final semester grades and higher grades in the Internet Addiction Test (Pearson -0,121, p-value: 0,045). Conclusions: The data of this study point to a major possibility of medical students developing Internet Addiction Disorder, with more severe dependence among those who are males, from lower social classes, in earlier periods of study, students from public universities, from cities with a population of less than 50.000 inhabitants and immigrants. The presence of Internet Addiction Disorder was inversely proportional to academic performance.

Antimalarials and macrolides: a review of off-label pharmacotherapies during the first wave of the SARS-CoV-2 pandemic

Abstract We critically analyzed clinical trials performed with chloroquine (CQ) and hydroxychloroquine (HCQ) with or without macrolides during the first wave of COVID-19 and discussed the design and limitations of peer-reviewed studies from January to July 2020. Seventeen studies were eligible for the discussion. CQ and HCQ did not demonstrate clinical advantages that justified their inclusion in therapeutic regimens of free prescription for treatment or prophylactic purposes, as suggested by health authorities, including in Brazil, during the first wave. Around August 2020, robust data had already indicated that pharmacological effects of CQ, HCQ and macrolides as anti-SARS-CoV-2 molecules were limited to in vitro conditions and largely based on retrospective trials with low quality and weak internal validity, which made evidence superficial for decision-making. Up to that point, most randomized and nonrandomized clinical trials did not reveal beneficial effects of CQ or HCQ with or without macrolides to reduce lethality, rate of intubation, days of hospitalization, respiratory support/mechanical ventilation requirements, duration, type and number of symptoms, and death and were unsuccessful in increasing virus elimination and/or days alive in hospitalized or ambulatory patients with COVID-19. In addition, many studies have demonstrated that side effects are more common in CQ-or HCQ-treated patients.

McKittrick-Wheelock syndrome secondary to rectal adenocarcinoma

Introduction: McKittrick-Wheelock syndrome is a rare condition that arises from a hypersecretory state secondary to large colorectal tumors, mainly villous adenomas, leading to an electrolytic disorder associated with chronic diarrhea that usually persists for years. It is a relatively unknown disease that can lead to severe complications such as acute kidney injury, severe hyponatremia, and hypokalemia. In fact, it causes death in most untreated cases. Surgical removal of the tumor is the most successful treatment, and symptoms tend to disappear after proper management. Case Report: A 62-year-old man with a 2-year history of mucoid diarrhea preceded by abdominal pain presented with acute kidney injury, hyponatremia, and hypokalemia. A digital rectal examination and sigmoidoscopy were performed, and revealed a large laterally-spreading tumor in the rectum. Further investigation showed a rectal tubulovillous adenoma with secondary McKittrick-Wheelock syndrome. An anterior resection of the rectum with a colonic J-pouch and a diverting ileostomy were performed, and the patient improved with the resolution of the renal failure and electrolyte disturbances. The histopathological analysis revealed an invasive rectal adenocarcinoma. Discussion: McKittrick-Wheelock syndrome is a condition with a low incidence that needs early intervention and proper diagnosis. It is of extreme importance that this disease is included in the differential diagnoses for chronic diarrhea associated with an electrolytic disorder. (AU)

Deep dermatophytosis caused by Trichophyton rubrum in immunocompromised patients

Abstract In immunosuppressed patients, dermatophytosis can be more invasive, affecting the dermis and subcutaneous tissues. The authors describe the cases of two patients with kidney and heart transplanted, respectively, that developed a deep dermatophytosis caused by Trichophyton rubrum, confirmed by culture and DNA sequencing. Both patients had concomitant onychomycosis, and both were treated with itraconazole for about two months, which was interrupted due to pharmacological interactions with the immunosuppressive drugs and switched to terbinafine, leading to clinical resolution within four months. Deep dermatophytosis should be considered when dealing with immunocompromised patients, especially when a superficial dermatophytosis is present. Oral treatment is necessary and terbinafine is a preferable option in solid organ transplant recipients because it has less pharmacological interactions.

Tempo de uso do smartphone e condições de saúde relacionadas em idosos durante a pandemia da covid-19 / Smartphone usage time and related health conditions in older people during the COVID-19 pandemic

Resumo Objetivo Avaliar o tempo de uso do smartphone e as condições de saúde relacionadas em idosos durante a pandemia da covid-19. Método Trata-se de estudo transversal com 237 idosos (≥60 anos) brasileiros, realizado entre junho e agosto de 2020. Responderam a um formulário on-line para obtenção das seguintes variáveis: perfil socioeconômico, condições de saúde e uso do smartphone. Análises bivariada e multivariada foram realizadas pelo programa SPSS, tendo como desfecho tempo de uso do smartphone. Resultados Do total, 69,2% (n=164) eram do sexo feminino, 48,5% (n=115) queixavam-se de dor cervical, 57,4% (n=136) tinham incapacidade cervical e permaneciam 6,2 horas por dia sentados na semana. Cerca de 54,4% (n=129) relataram aumento do uso do smartphone nos últimos meses, passando 4,2 horas/dia. Os idosos mais novos (p=0,038), não praticantes de atividade física (p=0,001), com avaliação de saúde boa (p=0,009) e maior tempo sentado (p=0,011) permaneciam mais tempo usando o dispositivo. Conclusão Devido ao uso do smartphone durante a pandemia da covid-19 associado a maior tempo sentado e ao sedentarismo alerta-se para as repercussões negativas na saúde física e mental dos idosos.

Abstract Objective To evaluate smartphone usage time and related health conditions in older people during the COVID-19 pandemic. Method This is a cross-sectional study of 237 older people (aged ≥60 years) Brazilians, carried out between June and August 2020. An online form was used to obtain the following variables: socio-economic profile, health status, and smartphone usage. Bivariate and multivariate analyzes were performed using the SPSS program with the outcome of smartphone usage time. Results Of the study individuals, 69.2% (n=164) were females, 48.5% (n=115) complained of cervical pain, 57.4% (n=136) had a cervical disability and remained 6.2 hours a day in the sitting position per week. Approximately 54.4% (n=129) reported increased smartphone usage in the past few months, reporting 4.2 hours of usage/day. Younger senior individuals (p=0.038), who did not practice physical activities (p=0.001), with good health assessment (p=0.009) and who spent more extended periods in the sitting position (p=0.011) spent more time using the device. Conclusion Considering the smartphone usage during the COVID-19 pandemic associated with more extended periods in the sitting position and a sedentary lifestyle, it is worth mentioning its adverse effects on the physical and mental health of older people.

Cannabis and cannabinoid use in autism spectrum disorder: a systematic review

Abstract Introduction Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by persistent deficits in social communication and social interaction, associated with the presence of restricted and repetitive patterns of behavior, interests, or activities. Cannabis has been used to alleviate symptoms associated with ASD. Method We carried out a systematic review of studies that investigated the clinical effects of cannabis and cannabinoid use on ASD, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA checklist). The search was carried out in four databases: MEDLINE/PubMed, Scientific Electronic Library Online (SciELO), Scopus, and Web of Science. No limits were established for language during the selection process. Nine studies were selected and analyzed. Results Some studies showed that cannabis products reduced the number and/or intensity of different symptoms, including hyperactivity, attacks of self-mutilation and anger, sleep problems, anxiety, restlessness, psychomotor agitation, irritability, aggressiveness perseverance, and depression. Moreover, they found an improvement in cognition, sensory sensitivity, attention, social interaction, and language. The most common adverse effects were sleep disorders, restlessness, nervousness and change in appetite. Conclusion Cannabis and cannabinoids may have promising effects in the treatment of symptoms related to ASD, and can be used as a therapeutic alternative in the relief of those symptoms. However, randomized, blind, placebo-controlled clinical trials are necessary to clarify findings on the effects of cannabis and its cannabinoids in individuals with ASD. Systematic review registration International Prospective Register of Systematic Reviews (PROSPERO), code 164161.

Nitrous oxide as an adjunctive therapy in major depressive disorder: a randomized controlled double-blind pilot trial

Objective: Major depressive disorder (MDD) is related to glutamatergic dysfunction. Antagonists of glutamatergic N-methyl-D-aspartate receptor (NMDAR), such as ketamine, have antidepressant properties. Nitrous oxide (N2O) is also a NMDAR antagonist. Thus, this study aimed to evaluate the effects of augmenting antidepressant treatment with N2O. Methods: This double blind, placebo-controlled randomized parallel pilot trial was conducted from June 2016 to June 2018 at the Hospital das Clínicas, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo. Twenty-three subjects with MDD (aged 18 to 65, on antidepressants, with a score > 17 on the 17-item-Hamilton Depression Rating Scale [HAM-D17]) received 50% N2O (n=12; 37.17±13.59 years) or placebo (100% oxygen) (n=11; 37.18±12.77 years) for 60 minutes twice a week for 4 weeks. The primary outcome was changes in HAM-D17 from baseline to week 4. Results: Depressive symptoms improved significantly in the N2O group (N2O: from 22.58±3.83 to 5.92±4.08; placebo: from 22.44±3.54 to 12.89±5.39, p < 0.005). A total of 91.7% and 75% of the N2O group subjects achieved response (≥ 50% reduction in HAM-D17 score) and remission (HAM-D17 < 7), respectively. The predominant adverse effects of N2O treatment were nausea, vomiting, and headache. Conclusion: N2O treatment led to a statistically significant reduction in HAM-D17 scores compared to placebo. Clinical trial registration: Brazilian Register of Clinical Trials, RBR-5rz5ch

The dark side of the esophagus

Acute esophageal necrosis (AEN), also known as "black esophagus," is an entity characterized by the circumferential black appearance of esophageal mucosa, usually associated with hypoperfusion and gastric outlet obstruction. This entity has a reported prevalence of up to 0.2%, affecting predominantly elderly men with multiple comorbidities. Most cases resolve with conservative treatment with no need of surgical intervention. However, the overall prognosis is poor, with mortality reaching one-third of cases due to the patient's underlying illness. In this article we present three cases of patients with AEN.

The dark side of the esophagus

Acute esophageal necrosis (AEN), also known as "black esophagus," is an entity characterized by the circumferential black appearance of esophageal mucosa, usually associated with hypoperfusion and gastric outlet obstruction. This entity has a reported prevalence of up to 0.2%, affecting predominantly elderly men with multiple comorbidities. Most cases resolve with conservative treatment with no need of surgical intervention. However, the overall prognosis is poor, with mortality reaching one-third of cases due to the patient's underlying illness. In this article we present three cases of patients with AEN.

Mucinous adenocarcinoma of the appendix with inguinal node metastases

Mucinous adenocarcinoma of the appendix is a rare neoplasm with a low propensity for lymph node metastasis. The present case refers to an appendicular mucinous adenocarcinoma with inguinal lymph node metastasis. A 71-year-old woman underwent an appendectomy due to a clinical presentation of acute appendicitis. However, the histological examination of the surgical specimen revealed a mucinous adenocarcinoma of the appendix. After staging, the patient underwent a right hemicolectomy and was proposed for adjuvant chemotherapy. At the 3rd year of follow-up, inguinal lymphadenopathy was diagnosed, which biopsy confirmed inguinal node metastases from primary colorectal cancer, with areas of extracellular mucin. Restaging revealed liver and peritoneal metastasis, and the patient was proposed for palliative chemotherapy. Appendicular neoplasms, due to their rarity, represent a diagnostic and therapeutic challenge. This clinical case depicts an unusual metastasis pathway for an unusual neoplasm.

Cross-cultural adaptation of the Internet Gaming Disorder Scale - Short Form (IGDS9-SF) to the Brazilian context

Abstract Introduction The Internet Gaming Disorder Scale - Short Form (IGDS9-SF) assesses the severity, harmful effects and/or consequences of excessive online and offline gaming. Its conciseness and theoretical foundations on current diagnostic criteria of gaming disorders make it a useful resource for clinical and screening settings. Objective To describe the process of cross-cultural adaptation of the IGDS9-SF to the Brazilian context. Methods The cross-cultural adaptation involved the steps of independent translation of the instrument, synthesis version, back-translation, pre-test and elaboration of the final version. Content validity assessment was conducted by a multidisciplinary committee of experts and consisted of both a quantitative analysis (calculation of content validity coefficients - CVC) and a qualitative analysis (assessment of the experts' comments and suggestions). The pre-test sample consisted of 30 gamers with variable sociodemographic characteristics. Results The cross-cultural adaptation of the scale followed the proposed protocol, and the CVC was satisfactory (≥ 0.83) for all the structures and equivalences assessed. Most of the suggestions made by the experts were accepted (mainly adjustments and language standardization). The gamers who participated in the pre-test judged the scale easy to understand and did not suggest changes. Discussion The Brazilian version of the IGDS9-SF showed adequate content validity and is available for researchers and clinicians, as well as for the investigation of additional psychometric characteristics.

Cross-cultural adaptation of the City Birth Trauma Scale for the Brazilian context

Abstract Background Posttraumatic stress disorder consists of a set of symptoms that occurs in response to one or more traumatic events and can occur in postpartum, from traumatic situations related to the birth or to the baby's health in the first days of life. It is important tracking the presence of birth trauma, but there is not available instruments in the Brazilian context for this purpose. Objectives To present the cross-cultural adaptation of City Birth Trauma Scale (BiTS) into Brazilian portuguese. Methods Cross-cultural adaptation involved independent translations, synthesis,back-translation, and submission to the original author's appreciation. After the scale was subjected to face validity, followed by a pilot study with postpartum mothers. Results All steps were performed for the cross-cultural adaptation. Regarding face validity, items evaluated concerning different types of equivalence, presented satisfactory agreement values (≥4.20). Most of the expert's suggestions were followed, being the main ones related to adjustments in prepositions, pronouns and verbal subjects. Pilot study showed that the mothers had been able to understand and respond to the instrument without adjustments. Discussion BiTS's Brazilian version proved to be cross-culturally adapted, ensuring the possibility of intercultural data comparison from the semantic, idiomatic, cultural, and conceptual perspectives. New studies are being conducted to attest its psychometric adequacy.

Etiologia e fatores associados à halitose: uma revisão integrativa da literatura / Etiology and factors associated with halitosis: an integrative literature review

Objetivo: avaliar quais as possíveis causas e quais são os fatores associados ao surgimento da halitose. Métodos: foi realizada uma revisão nos bancos de dados PubMed e SciELO, utilizando os descritores e sinônimos MeSH organizados em lógica booleana: 'Halitosis' AND 'Risk Factors' OR 'Association' OR 'Etiologies', com as seguintes etapas: identificação dos artigos, triagem, elegibilidade e inclusão. Apenas artigos publicados entre os anos de 2015-2020, ensaios clínicos randomizados, estudos transversais ou de coorte foram incluídos na revisão. Foram excluídos protocolos de estudos e os artigos que não estavam nos critérios e objetivo desta revisão. Resultados: de 240 artigos encontrados, 22 foram inclusos. Desses, 50% demonstraram que a falta ou a deficiência dos hábitos de higiene oral se relacionam com a halitose. Ainda, 40,9% deles se referem à saburra lingual como um forte fator etiológico e 36,4% demonstram que a doença periodontal está diretamente associada com o mau hálito. Além disso, em relação a outras condições locais e sistêmicas, xerostomia (13,6%), doença gastrointestinal e refluxo laringofaríngeo (9,1%), rinite e diabetes (4,5%) também demonstraram associação. Considerações finais: a halitose pode estar associada com higiene bucal, saburra lingual, doença periodontal, alguns hábitos e quadros sistêmicos.(AU)

Objective: to evaluate the possible causes and what are the factors associated with the onset of halitosis. Methods: a review was performed in the PubMed and SciELO databases, using the descriptors and synonyms MeSH organized in Boolean logic: 'Halitosis' AND 'Risk Factors' OR 'Association' OR 'Etiologies', with the following steps: identification of articles, screening, eligibility and inclusion. Only articles published between 2015- 2020; randomized clinical trials; cross-sectional or cohort studies were included in the review. Study protocols and articles that were not in the criteria and objective of this review were excluded. Results: Of 240 articles found, 22 were included. Of those, 50% showed that the lack or deficiency of oral hygiene habits are related to halitosis. Furthermore, 40.9% of them refer to tongue coating as a strong etiological factor and 36.4% demonstrate that periodontal disease is directly associated with bad breath. Moreover, in relation to other local and systemic conditions, xerostomia (13.6%), gastrointestinal disease and laryngeal reflux (9.1%), rhinitis and diabetes (4.5%) also demonstrated an association. Final considerations: Halitosis may be associated with oral hygiene, lingualcoating, periodontal disease, some habits and systemic conditions.(AU)

Função renal alterada: prevalência e fatores associados em pacientes de risco / Altered renal function: prevalence and associated factors in risk patients / Función renal alterada: prevalencia y factores asociados en pacientes de riesgo

Introdução: a doença renal crônica (DRC) nos estágios iniciais não apresenta manifestações clínicas e, por isso, as pessoas somente procuram as unidades de saúde já na fase terminal da doença. Isso ainda é uma rotina no Brasil. Objetivo: identificar a prevalência de taxa de filtração glomerular estimada (TFGe) alterada e fatores associados em usuários do sistema único de saúde com Diabetes Mellitus e/ou com Hipertensão Arterial Sistêmica de alto e muito alto risco para doença cardiovascular. Materiais e Métodos: estudo transversal com prontuários de 331 usuários do Centro Estadual de Atenção Especializada no Centro-Oeste mineiro/ Minas Gerais/ Brasil, entre setembro de 2017 a junho de 2019. Realizou-se análise descritiva, univariada e regressão logística multivariada. Resultados: do total de participantes, 118 (35,6%) tiveram TFGe alterada. Identificou-se associação significativa da TFGe alterada com a idade: idosos ≥ 60 anos apresentaram 5,53 vezes mais chance de ter a TFGe alterada. Os participantes em uso da polifarmácia tiveram 2,64 vezes mais chance de terem a TFGe alterada. Discussão: em analogia com estudos semelhantes, registrou-se a ausência de acompanhamento da instalação e desenvolvimento da DRC nas fases iniciais, implicando em abordagem tardia e ações limitadas para preservação das funções renais. Conclusões: identificou-se alta prevalência de TFGe alterada (35,6%), sem registros nos prontuários que pudessem direcionar uma abordagem preventiva da degeneração das funções renais. A idade avançada e polifarmácia foram identificadas como variáveis independentes para alteração da função renal.

Introduction: Chronic kidney disease (CKD) does not have any clinical symptoms in the early stages and, therefore, most people only attend healthcare units when they are already in the terminal phase of the disease, which is still common in Brazil. Objective: To identify the prevalence of altered estimated glomerular filtration rate (eGFR) and associated factors in users of the unified health system suffering from diabetes mellitus and/or systemic hypertension at high risk of cardiovascular disease. Materials and Methods: A cross-sectional study was conducted based on the medical records of 331 users attending the State Specialty Care Center located in the west-central region of Minas Gerais, Brazil between September 2017 and June 2019. A descriptive univariate analysis and multivariate logistic regression were performed. Results: A total of 118 (35.6%) of the participants had altered eGFR. A significant association between altered eGFR and age was identified: older people ≥ 60 years old were 5.53 times more likely to have altered eGFR. Participants using polypharmacy were 2.64 times more likely to have altered eGFR. Discussion: In line with similar studies, a lack of follow-up on the initiation and development of CKD in the early stages was identified, implying a late approach and limited actions to preserve kidney function. Conclusions: A high prevalence of altered eGFR was identified (35.6%) with no records in the tables that could lead to a preventive approach to impaired kidney function. Advanced age and polypharmacy were identified as independent variables in the alteration of kidney function.

Introducción: La enfermedad renal crónica (ERC) en sus primeras etapas no presenta manifestaciones clínicas y, por lo tanto, la mayoría de las personas solo se acercan a las unidades de salud cuando ya están en la fase terminal de la enfermedad, lo cual sigue siendo habitual en Brasil. Objetivo: Identificar la prevalencia de la tasa estimada de filtración glomerular (TFG) alterada y los factores asociados en usuarios del sistema de salud único que sufran de diabetes mellitus y/o hipertensión sistémica de alto riesgo de enfermedad cardiovascular. Materiales y métodos: Se realizó un estudio transversal con las historias clínicas de 331 usuarios del Centro Estatal de Atención Especializada ubicado en el centro oeste de Minas Gerais, Brasil entre septiembre de 2017 y junio de 2019. Se realizaron un análisis univariado descriptivo y una regresión logística multivariante. Resultados: Del total de participantes, 118 (35,6%) tenían la TFG alterada. Se identificó una asociación significativa entre la alteración de la TFG y la edad: los ancianos ≥ 60 años tenían 5,53 veces más posibilidades de tener la TFG alterada. Los participantes que utilizaron la polifarmacia tenían 2,64 veces más probabilidades de que se alterara la TFG. Discusión: En consonancia con estudios similares, se registró la falta de seguimiento del inicio y el desarrollo de la ERC en las primeras etapas, lo que implica un enfoque tardío y acciones limitadas para preservar las funciones renales. Conclusiones: Se identificó una alta prevalencia de TFG alterada (35,6%) sin registros en las tablas que pudieran conducir a un enfoque preventivo de la degeneración de la función renal. La edad avanzada y la polifarmacia se identificaron como variables independientes en la alteración de la función renal.

Associação entre condições sistêmicas e gravidade da doença periodontal em pacientes atendidos na Clínica-Escola da UFCG / Association between systemic conditions and the gravity of periodontal disease in patients attended at the UFCG School clinic

Introdução: A doença periodontal é uma doença inflamatória crônica dos tecidos de proteção e suporte dos dentes. As doenças ou alterações de ordem sistêmica, como diabetes, alterações cardiovasculares e pulmonares, distúrbios hormonais e outras, não iniciam a doença periodontal, mas podem acelerar uma doença preexistente, aumentando sua progressão e destruição tecidual. Objetivo: O presente estudo teve como objetivo avaliar, por meio de prontuários clínicos, uma possível associação entre as condições sistêmicas e a gravidade da doença periodontal em pacientes atendidos na Clínica-Escola de Odontologia da Universidade Federal de Campina Grande, campus CSTR (UFCG-CSTR). Material e método: Para o estudo, foram avaliados 1.035 prontuários clínicos dos pacientes que procuraram atendimento na Clínica-Escola de Odontologia da UFCG-CSTR durante os anos de 2012 a 2017. Resultado: A população estudada apresentou prevalência do sexo masculino (50,9%) e diagnóstico de doença gengival (63,6%) e periodontal (35,8%). As condições sistêmicas mais prevalentes foram hipertensão (15%), diabetes (7,5%) e cardiopatias (5,8%). Além disso, 20,2% relataram ser fumantes ou ex-fumantes, enquanto o uso de medicação foi observado em 28,3% dos casos. Foi verificada associação estatisticamente significativa entre doença periodontal, sexo masculino, faixa etária mais avançada, hipertensão arterial, tabagismo ou histórico de tabagismo e diabetes. Conclusão: Foi observada uma quantidade de dentes igual ou menor do que 10 com maior frequência entre os pacientes com idade igual ou superior a 60 anos, hipertensos, diabéticos, cardiopatas e fumantes ou ex-fumantes, sugerindo, desse modo, uma maior gravidade da doença periodontal nesses indivíduos.

Introduction: Periodontal disease is a chronic inflammatory disease of the protective and supporting tissues of the teeth. Systemic diseases or changes, such as diabetes, cardiovascular changes, lung changes, hormonal disorders and others, do not start periodontal disease, however they can accelerate a pre-existing disease increasing its progression and tissue destruction. Objective: The present study aimed to evaluated, through clinical records, a possible association between systemic conditions and the severity of periodontal disease in patients seen at the Clinical School of Dentistry, Federal University of Campina Grande, Campus CSTR (UFCG-CSTR). Material and method: The study evaluated 1035 medical records of patients who sought care at the Clinical School of Dentistry of the Federal University of Campina Grande, Campus CSTR during the years 2012 to 2017. Result: The studied population had a prevalence of males (50.9%) and a diagnosis of gingival and periodontal disease of 63.6% and 35.8%, respectively. The most prevalent systemic conditions were hypertension (15.0%), diabetes (7.5%) and heart disease (5.8%). About 20.2% reported being smokers or ex-smokers. The use of medication was observed in 28.3% of the cases. There was a statistically significant association between periodontal disease, male gender, older age group, arterial hypertension, smoking or history of smoking and diabetes. Conclusion: A number of teeth equal to or less than 10 was observed more frequently among patients aged 60 years or more; hypertensive, diabetic, cardiac patients and smokers or ex-smokers, thus suggesting a greater severity of periodontal disease in these individuals.

Safe-by-design development of a topical patch for drug delivery

Few topical products have been developed specifically to treat acute and chronic arthritis and inflammation, using non-steroidal anti-inflammatory drugs (NSAIDs). The lack of dosing accuracy commonly found in locally applied semisolid products for cutaneous use is a critical issue that leads to treatment failure. The aim of the present work is to develop a differentiated and innovative topical patch based on a monolithic hydrogel for ibuprofen skin delivery, in order to provide a safer and accurate way of drug administration along with improved treatment compliance. Topical patches based on hydroxypropylmethylcellulose (HPMC) were optimized in composition, in terms of enhancer and adhesive, supported on a systematic assessment of in vitro release and permeation behavior and adhesion properties. Several mathematical models were used to scrutinize the release mechanisms from the patches. In vitro release kinetics was shown to be mainly driven by diffusion. However, other mechanisms seemed to be also present, supporting the feasibility of using patches for sustained drug delivery. PEG 200 provided the best permeation rate, with a permeation enhancement ratio of ca. 3 times higher, than the commercial reference. The addition of Eudragit L30D 55 to the formulation led to the best adhesion profile, thus achieving a successful development based on a safe-by-design concept.