Fabrication and in- vitro permeation studies of indomethacin-ficus carica fruit mucilage patches.

The main objective of the present study was to develop matrix-moderated transdermal systems of Indomethacin using various proportions of Ficus carica fruit mucilage. Physical evaluation was performed such as moisture content, moisture uptake, tensile strength, flatness and folding endurance. In-vitro permeation studies were performed in a Keshary-Chien diffusion cell. The matrix-type transdermal systems were prepared using Indomethacin with Ficus carica fruit mucilage by the solvent evaporation technique. The interactions between Indomethacin and Ficus carica fruit mucilage were performed. The transdermal patches were subjected to various physicochemical parameters viz., mechanical properties, permeation studies and skin irritation studies. The prepared patches possessed satisfactory pre-formulary and formulary characteristics. In vitro permeation studies were performed using a Keshary-Chien diffusion cell across hairless Albino rat skin. The non-ionic surfactants Span 80, Glycerin, Propylene glycol in the formulation played a role as permeability enhancer. The patches were seemingly free of potentially hazardous skin irritation. The experimental results shows that the release of drug from the patch delayed in controlled manner as the proportion of Ficus carica increased. It was concluded that Indomethacin can be developed as a transdermal patches with Ficus carica fruit mucilage.

Design and evaluation of sustained release matrix tablets of glimepiride based on combination of natural and synthetic polymers.

The present research work was aimed to develop matrix tablets of Glimepiride with Aloe barbadensis miller leaves mucilage and Povidone and to study its functionality as a matrix forming agent for sustained release tablet formulations. Physicochemical properties of dried powdered mucilage of Aloe barbadensis miller mucilage and Povidone tablet blend were studied. Various formulations of Glimepiride Aloe barbadensis miller mucilage and Povidone were prepared. They found to have better satisfactory physicochemical properties with low SD values. The swelling behavior and release rate characteristics were studied. The dissolution study proved that the dried Aloe barbadensis miller mucilage and Povidone combination can be used as a matrix forming material for making Sustained release matrix tablets.