ABSTRACT
Cypermethrin (CYP) and Carbendazim (CAR) are synthetic pesticides that have been in use for more than a decade. A study of a low-dose exposure of these pesticides in rat administered different doses of each of these compounds, individually and in combination, followed by investigation of the biochemical and histological status of the rat brain, will highlight early enzymatic and histological changes that generally accompanied a toxic response in the animal. Thus, even though CYP was used at 5, 10, 25 and 50mM, for durations of 12 and 24hr in the different groups of rats, results of the study indicate that simultaneous with changes in enzyme activity, histological sections of specific rat brain yielded observations suggestive of degenerating tissue morphology and architecture even at the low-dose levels.. Tissue specific changes in the activities of these marker enzymes were suggestive of the lack of tissue resistance to pyrethroids or carbamates.
ABSTRACT
Enzymatic and histological change in the testicular cells of rats treated orally and intradermally for 45 days with gibberellic acid (GBA) in independent studies is reported. Assay of hexokinase (HK), acid phosphatase (AcP) and alkaline phosphatase (AkP) in rat testicular tissue homogenate preparations yielded results that suggested changes in these enzyme activities relative to their respective controls. Histological studies showed loss of germ cells, derangement of the germinal cells, and reduction in the size of the seminiferous tubules and dystrophy of Leydig cells. More importantly decreased sperm count in the lumen was observed. A dysregulatory role is thus established for GBA in rat testicular cell function. This compound may serve as an inhibitor of testicular cell function.