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Introduction: Systemic Lupus Erythematosus (SLE) is an autoimmune disease in which organs, tissues, and cells undergo damage mediated by tissue-binding autoantibodies and immune complexes. SLE primarily occurs in young women in their twenties. The disease expression is greatly influenced by the combined effect of genetic, environmental, demographic and geographical factors. Genetic factor superimposed on certain environmental factors plays a very pivotal role in manifesting abnormal immunological response. There is a wide variation in the natural history of systemic lupus erythematosus among different ethnic and geographical groups. Severity ranges from a mild disease with rash and arthritis to a devastating illness with renal failure and central nervous system involvement. The purpose of this study is to delineate the clinical pattern and disease course in patients with SLE at our centre and to compare it with National data on lupus patients. Aim and objectives: To describe the clinical profile in systemic lupus erythematosus patients and to assess the disease activity of SLE with SLEDAI criteria in SLE patients. Materials and methods: This study was an observational study conducted in 50 patients of Systemic Lupus Erythematosus who were admitted in Department Of Medicine, Gandhi Hospital, Telangana during the period from January 2017 – June 2018. Aishwarya Sirikonda, Mrudula Kolli, M. Raja Rao, Shyamala Srujana. A study of clinical profile and assessment of disease activity in systemic lupus erythematosus patients. IAIM, 2019; 6(10): 22-27. Page 23 Results: The age of the patients ranged from 16 to 48 years with a mean of 26.52 years. Diagnosis was based on the SLICC criteria for the diagnosis of SLE. All the patients satisfied at least 4 criteria needed for diagnosis of SLE as per the recommendations. Conclusion:
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Background: Respiratory tract lesions are commonest for which patients attend the chest clinics. The lesions may be inflammatory or neoplastic. Materials and methods: 594 patients attending to chest clinics and admitted in Government General and Chest Hospital Hyderabad during the period of 2 years from September 2006 to August 2008 were included. All of the patients with clear cut evidence of tuberculosis and pneumonia were excluded from the study. Results: Majority of patients were in the age group of 41-60 years. Youngest patient was 20 years. Males were 443 (74.57%) and females were 151 (25.43%). Commonest presentation was cough with expectoration 567 (94.45%) followed by fever 101 (17.0%), chest pain 84 (14.14%), hemoptysis 57 (9.59%), Shortness of breath 51 (8.58%) and weight loss 34 (5.72%). Conclusion: In the present study even though malignancy was proved with positive cytologic examination by identifying the malignant nature of the cells, the typing of cell was difficult in some cases, but was excellent with squamous cell carcinoma and small cell carcinoma.
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Introduction: Lichenoid tissue reaction or interface dermatitis embraces several clinical conditions, the prototype of which is lichen planus and its variants. Others include drug induced lichenoid dermatitis, special forms of lichenoid dermatitis, lichenoid dermatitis in lupus erythematosus, and other disorders all of which have salient clinical and histological features. The aim of this study was to correlate the clinical features with histopathological findings in all clinically suspected cases of lichen planus and assess the clinical diagnostic accuracy. Materials and methods: This study had been carried out over a period of 2 years from July 2015 to June 2017 in the Department of Pathology, Gandhi Hospital. Histopathological sections of skin biopsies from 85 patients were studied after routine H and E staining and morphological changes were noted. The patients’ clinical findings were then correlated with the histological changes. The results were then analysed. Results: Total numbers of biopsies inclusive of LP and LP like lesions were 85. Among them, the number of patients having LP was 50. The age ranged from 18 to 65 years (mean 37.1 years). The mean duration of the lesion was 12.02 months (approx 1 year). Males were affected more than females. Out of the 85 cases, 50 were Lichen planus and 35 were lichenoid eruptions. Of the Lichen planus, 31 (61.6%) cases were of classical lichen planus, 6 (13.3%) cases were of hypertrophic lichen planus, 4 (8.3%) cases were of lichen planus pigmentosus, 4 (6.6%) cases were of actinic lichen planus, 3 (5%) cases were of eruptive lichen planus, 1 (1.6%) case each of atrophic lichen planus, annular lichen planus. N. Srivani, B.V.N. Sravani, Shyamala Srujana, O. Shravan Kumar. A study of clinical and histopathological correlation of lichen planus. IAIM, 2017; 4(9): 136-144. Page 137 Conclusion: In the present study, maximum number of cases occurred in age group of 18-28 years. Though pruritis is a common symptom, it is nonspecific. Therefore, histopathology remains the most important diagnostic tool for proper evaluation of Lichenoid eruptions/ Lichen planus.