Relationship between OGTT blood glucose levels and early kidney damage in patients with essential hypertension / 医学研究生学报

Objective More and more research shows microangiopathy may occur in the early stage of diabetes. The purpose of this study was to observe the relationship between OGTT 1-hour hyperglycemia (1hPG) and 2-hour hyperglycemia (2hPG) levels and urinary albumin creatinine ratio (UACR).Methods We retrospectively analyzed 408 patients with primary hypertension of grade 2 or above who were eligible for 2015 World Health Organization (WHO) outpatient and inpatient visits from September 2015 to April 2018 in our hospital for a course of up to 10 years. All selected participants underwent an OGTT test (1 and 2 hour post-sugar glucose) and records were made on fasting plasma glucose (FPG), OGTT1-hour blood glucose (1 hPG), OGTT 2-hour blood glucose (2 hPG). All the patients were divided into 4 groups according to blood glucose levels: NGT group (n=100), 1 h PG group(n=102), 2h PG group(n=104), 1h PG/2h PG group (n=102). Records were made on the clinical data of 408 patients, including height, weight, BMI, gender, age, history of hypertension, smoking history, blood pressure, blood lipids, creatinine and other general clinical data, and the calculation of glomerular filtration rate (eGFR) values was based on creatinine values and age values to analyze the relationship between 1 hHPG and 2 hHPG levels with ACR.Results No significant difference was found among the four groups in the aspects of hypertension course, age, gender, body mass index (BMI), diastolic blood pressure, lipid metabolism index and fasting blood glucose(P>0.05). There were significant difference in systolic blood pressure, serumcreatinine, eGFR, and ACR among different levels of increased blood glucose(P<0.05). ACR in 1h PG group, 2h PG group and 1h PG/2h PG group were significantly higher than NGT group(P<0.01), ACR in 1h HPG/2hHPG was significantly higher than 1h PG group(P<0.05) and ACR in 1h PG group was significantly higher than 2h HPG group(P<0.05). The logistic regression analysis showed that 1h PG(OR=2.461, 95%CI:1.947-3.112), creatinine (OR=1.071, 95%CI:1.027-1.117) and 2h PG(OR=2.016, 95%CI:1.500-2.710) were risk factors for microalbuminuria(P<0.01).Conclusion The abnormalities of 1h PG and 2h PG are associated with ACR, which may become the key index for predicting early kidney damage.

Study on the status and related socio-psychological factors of maternal depression among high-risk pregnancy women in Harbin city / 中华预防医学杂志

<p><b>OBJECTIVE</b>This study aimed to investigate the depression status among high-risk pregnancy women, and to analyze its relevant social and psychological factors.</p><p><b>METHODS</b>A total of 42 high-risk pregnancy women and 40 normal pregnancy women in a teaching hospital in Harbin city were followed up at time points of 32 - 36 weeks pregnancy, one week before labor, one week postpartum, and six weeks postpartum, respectively. During follow-up, the basic situation, social psychosocial factors of pregnancy women were collected and the depression of pregnancy women was measured by self-designed questionnaire and self-rating depression scale. The Edinburgh Postnatal Depression Scale (EPDS) was applied at timepoint of one week postpartum. Single factor analysis and the unconditional multivariate logistic regression were applied for analyzing the on the related social-psychosocial factors among high-risk pregnancy women.</p><p><b>RESULTS</b>The age of high-risk pregnancy women was (31.0±5.6), and the age of normal pregnancy women was (30.5±3.8) (t=0.169, P>0.05). The results showed that the depression rate in high-risk pregnancy women was 45.2% (19/42), which was 25.0% (10/40) in normal pregnancy women, the difference was significant (χ2=3.671, P=0.045). The depression rates at different time points were 30.9% (13/42), 42.9% (18/42), 23.8% (10/42), 26.2% (11/42) in high-risk pregnancy women respectively, and 25.0% (10/40), 15.0% (6/40), 20.0% (8/40), 17.5% (7/40) in the control group respectively, the difference of the depression rates among groups at one week before labor was significant (χ2=7.680, P<0.01), the difference among groups at 32-36 weeks pregnancy (χ2=0.133, P=0.80), at one week postpartum (χ2=0.174, P=0.79) and at six weeks postpartum (χ2=0.903, P=0.43) were not significant. At one week postpartum and six weeks postpartum periods, the EPDS depression rate were 12.5% (4/32), 30.4% (7/23) in case group respectively, 8.3% (3/36), 22.9% (8/35) in control group respectively, the difference were not significant (χ2=0.319, 0.416, P=0.573, 0.519). There were significantly associations between the depression mood of one week before labor and the depressive symptoms of six weeks postpartum in both groups (r=0.824, 0.677, both P values were <0.05). The risk factors for maternal depression among high-risk pregnancy women were not ready for production (OR=2.73, P<0.01) and fearing of childbirth safety (OR=2.89, P<0.01).</p><p><b>CONCLUSION</b>The depression date of high-risk pregnancy was high, especially at the time point one week before labor. Risk factors of maternal depression among high-risk pregnancy were "not ready for production" and "fear of childbirth safety".</p>

Familial aggregation of metabolic syndrome in adolescents with paternal metabolic syndrome / 中华流行病学杂志

Objective To analyze the impact of parental Metabolic Syndrome(MS)on adolescents,and to explore the familial aggregation of MS with its components.Methods Using a 1:3 case-control familial study design to choose 26 MS male patients as proband and 78 healthy men as controls.Data regarding phenotype of their adolescence offspring were collected.Height,weight,waist circumference(WC),blood pressure,body mass index(BMI),waist-to-hip ratio(WHR)and waist-to-height ratio(WHtR)were measured or calculated.FPG,TC,TG,HDL-C and LDL-C were detected by automatic biochemical analyzer and hs-CRP was detected.Results WC,WHtR,WHR,DBP and hs-CRP of those adolescents with paternal MS were significantly higher than in controls(P＜0.05).Rates of MS,Obesity depend WC,low level of HDL-C of adolescent with paternal MS were significantly higher than in controls(P＜0.05).The rate of number on MS was significantly higher in case group than in control(r=0.231,P＜0.05).Conclusion The phenotypes of MS were different between adolescents with or without parental MS,indicating that the familial aggregation of MS had been existed in their adolescent offspring,and mainly presented in central obesity,increased blood pressure and inflammation.

Risk factors for emotional abuse in 844 adolescents / 中国当代儿科杂志

<p><b>OBJECTIVE</b>Emotional abuse and neglect is an under-recognized, but is a common form of child abuse. This study aimed to investigate the risk factors for emotional abuse in adolescents.</p><p><b>METHODS</b>A cross-sectional survey on emotional abuse was conducted by anonymous self-administered questionnaire in 865 adolescents randomly sampled from three junior schools in Harbin City. A total of 844 valid questionnaires were received. Risk factors were studied by multivariate non-conditional regression analysis.</p><p><b>RESULTS</b>Over the past year, 47.3% of the 844 respondents suffered from emotional abuse. Monovariate regression analysis indicated that emotional abuse was related to 19 factors, including children's health status, parental marital status, parental educational levels, family rearing patterns, family atmosphere and so on. Multivariate regression analysis showed poor children's health status (OR=1.877, P=0.001), bad parental marital status (OR=1.768, P=0.004), and unjustifiable family rearing patterns [over-interference (OR=3.004, P=0.006) and assentation (OR=5.430, P=0.032)] were risk factors for the occurrence of emotional abuse. The harmonious family atmosphere and the harmonious relations between children and their parents were protective factors for emotional abuse.</p><p><b>CONCLUSIONS</b>The prevalence of emotional abuse is high in adolescents. Poor children's health status, bad parental marital status and unjustifiable family rearing patterns are risk factors for the occurrence of emotional abuse.</p>