ABSTRACT
Objective :To analyze therapeutic effect of Mongolian medicine Guanxinshutong (MM) capsule on restenosis af—ter stenting in patients with acute myocardial infarction (AMI).Methods : The 108 AMI patients ,who received stenting in our hospital from May 2014 to May 2016 ,were selected.The patients were equally divided into routine treatment group and MM group (received MM capsule based on routine treatment group ) ,therapeutic processes of both groups was one year .Serum levels of endothelin (ET)—1 ,nitric oxide (NO) and C reactive protein (CRP) before and one year after treat—ment ;recurrence rate of angina pectoris ,coronary restenosis rate and incidence rate of adverse cardiac events during one—year follow—up were observed and compared between two groups .Results : Recurrence rates of angina pectoris on six months and one year after treatment were significantly lower than that of three months after treatment (9.25%,5.56%vs.33.33%) in MM group (P＝0.002 ,0.001) ,and significantly lower than those of routine treatment group (25.93%, 22.22%) , P＝0.023 ,0.012. On one year after stenting ,coronary restenosis rate of MM group was significantly lower than that of routine treatment group (9.26% vs.33.33%) , P＝0.002. Compared with before treatment ,on one year af—ter treatment ,there were significant reductions in serum ET—1 and CRP levels ,and significant rise in NO level in two groups , P＜0.01 all ;compared with routine treatment group on one year after treatment ,there were significant reductions in serum levels of ET—1 [(125.09 ± 33.41) ng／L vs.(107.16 ± 34.26) ng／L] and CRP [(18.59 ± 4.63) mg／L vs.(7.23 ± 3.74) mg／L] ,and significant rise in NO level [ (6.81 ± 1.47) μmol／L vs.(11.45 ± 1.35) μmol／L] in MM group , P＜0.01 all.During one—year follow—up ,incidence rate of adverse cardiac events in MM group was significantly lower than that of routine treatment group (9.26% vs.25.93%) , P＝0.023. Conclusion : Mongolian medicine Guanxinshutong cap—sule can significantly prevent restenosis ,reduce recurrence of angina pectoris ,serum ET—1 and CRP levels and incidence of adverse cardiac events ,and improve prognosis in AMI patients after stenting .
ABSTRACT
Objective To investigate the relationship of galectin 3(Gal-3)and microalbuminuria(MAU) with left ventricular hypertrophy(LVH)in elderly patients with hypertension. Methods 120 patients with LVH were included in the study as LVH group and another patients with non-LVH group as NLVH group with the age, sex ratio and length of stay matched to the LVH group.The conditional Logistic regression was used to analyze the independent risk factors of LVH.Results The single factor analysis showed a positive correlation of LVH with the course of disease,blood pressure control,BMI,NT-proBNP,Gal-3,MAU and education level. By multivariate Logistic regression,course of disease,blood pressure,Gal-3 and MAU were included in the model,with the OR (95% CI)of 1.062(1.001~2.237),1.643(1.527~5.185),2.816(2.231~8.872)and 3.736(3.151~11.391). Conclusion As independent risk factors,the course of disease,control of blood pressure,Gal-3 and MAU are significantly correlated with LVH.