ABSTRACT
A total of 74 patients with apparent early stage epithelial ovarian cancer who underwent exploratory laparotomy at King Chulalongkorn Memorial Hospital or other hospitals and were referred for further treatment, were evaluated. Formalin fixed paraffin-embedded ovarian tissue specimens were collected and immuno-stained with HER-2/neu antibodies for comparison with clinicopathologic data after median follow up of 46 months (range 3 - 83 months). The prevalence of HER-2/neu overexpression in these patients was 10.2%. No significant correlation between HER-2/neu overexpression and clinicopathological parameters (stage, ascites, capsular rupture, capsular adherence, histological subtype and histological grade) was found. Disease free survival and overall survival did not statistically differ between those with lesions positive or negative for HER-2/neu overexpression.
Subject(s)
Adenocarcinoma, Clear Cell/metabolism , Adenocarcinoma, Mucinous/metabolism , Adult , Aged , Carcinoma, Endometrioid/metabolism , Cell Membrane/metabolism , Cystadenocarcinoma, Serous/metabolism , Female , Humans , Immunoenzyme Techniques , Middle Aged , Neoplasm Recurrence, Local/diagnosis , Neoplasm Staging , Ovarian Neoplasms/diagnosis , Paraffin Embedding , Prognosis , Receptor, ErbB-2/metabolism , Retrospective Studies , Biomarkers, Tumor/metabolismABSTRACT
OBJECTIVE: To investigate the prevalence of abnormal Papanicolaou smear in pregnant patients who attend the Antenatal Care Clinic at Thammasat University Hospital. MATERIAL AND METHOD: Pregnant patients who attended the antenatal care clinic at Thammasat University Hospital from August 2003 to December 2003 were recruited for Papanicolaou test. Patients who had abnormal results of equally or over "abnormal squamous/glandular cells of undetermined significance" were assigned for colposcopy and colposcopic biopsy to confirm the result. RESULTS: From 500 Papanicolaou smear performed, there were only four patients who had abnormal Pap tests, which were: 2 ASC-US and 2 LSIL. The prevalence of abnormal Pap smear in pregnant patients who attended the antenatal clinic at Thammasat University Hospital was 0.8 percent. CONCLUSION: The prevalence of abnormal Papanicolaou smear in pregnant patients attending antenatal care clinic at Thammasat University Hospital was quite low in compares with other literature.