ABSTRACT
In this article the activities of succinic dehydrogenase, H~+ -ATPase and creatine kinase in skeletal muscle and heart mitochondria of rats fed with low-Se diet from kashin-beck disease area for 3 to 5 months were observed. The experiments showed that the activities of these three membrane binding enzymes were decreased significantly in mitochondria of rats fed with low-Se diet for 3 to 5 months, as compared to rats suplemented with sodium selenite, but still had not reached the levels in rats fed with diet from Xi'an area.These results suggested that the disturbance of energy metabolism may be induced when the rats fed with low-Se diet for long term.
ABSTRACT
Effects of the low selenium diet in the Kashin-beck disease area on activity of lysosomal cathepsin D and alkaline phosphatase of cartilage in rats were studied. The results of the experiments showed that the free type and total activities of lysosomal cathepsin D of cartilage in rats fed with low-selenium diet were higher than Selenium-supplemented group and Xi'an group. The acuvity of alkaline phosphatase in low-selenium group was lower than selenium-supplemented group and Xi'an group.
ABSTRACT
Chronic hepatic injury animal model induced by TEF was made with carbontetrachloride, ethyl alcohol and a high-fat feed. An increase in serum GPT, LDH_5 and r-globulin, a decrease in serum albumin and a remarkable increase in hepatic collagen were found. The results indicated that all biochemical data obtained in this model is similar to those in patients with chronic active hepatitis.