ABSTRACT
Objective To evaluate the diagnostic value of dynamic contrast enhanced MRI (DCE-MRI)in angiogenesis and invasion of ovarian tumors .Methods 98 patients with pathological-confirmed ovarian tumors without any treatment underwent plain MRI and DCE-MRI before operation .The plain MR images and DCE-MRI data were retrospectively analyzed .Value of Ktrans and Ve was detected by pharmacokinetic model .The expression of VEGF and MMP-2 in ovarian tumors was examined by immunohistochemistry .The correlation between DCE-MRI parameters and immunohistochemical results was analyzed .Results The expression of VEGF and MMP-2 was sig-nificantly higher in the malignant group compared with that in the benign group (both P<0.05).The value of Ktrans and Ve was significantly lower in the benign group compared with that in the malignant group ( both P<0.05) .The value of Ktrans and Ve was positively correlated with the expression of VEGF and MMP-2.Conclusion DCE-MRI can noninvasively evaluate the angiogenesis and invasion of ovarian tumors in vivo , which has important signifi-cance for clinical treatment and prognostic assessment .
ABSTRACT
Objective To probe into the anatomy and clinical application of the facial nerve canal surface by multislice spiral CT image curved planar reformation. Methods Fifty patients with facial nerve disease were selected as study group from January to November in 2010, 50 healthy subjects were selected as control group, using models of multislice spiral CT scan for the patient, scanning from the upper edge of the orbital under external auditory canal edge of the connection as a horizontal line, ranging from the lower edge of mastoid process to the petrous bone on the edge of the data obtained in the Wizard workstation reconstruction. All the measurements were more than two measurements of the average physician. Results Normal facial nerve canal in control group could be displayed clearly in an image, display rate was 100.00%(50/50), and the segment data could be accurately measured; axial reconstruction, reconstruction of coronal and sagittal reconstruction of the three comparison of measured direction, fan sections, horizontal and vertical segments of the length and diameter were not significantly different (P＞0.05), and the first and second bending angle of bending angle was no significant difference (P ＞ 0.05 ). Compared with control group, the patients with vascular disease in study group showed significantly decreased rate, the difference was significant (P ＜ 0.05). Conclusion Curved planar reformation of multislice spiral CT diagnosis of facial nerve canal disease has great clinical significance, should be widely applied.