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Objective Toinvestigatethevalueof3.0T MRreducedfield-of-view (rFOV)IVIM-DWIondistinguishingprostate cancerandprostatehypertrophy.Methods 30patientswithpathologicallyprovenprostatecancerand38patientswithprostatehypertrophy accordingtotheresultsofbiopsywereanalyzedretrospectively,whounderwent3.0T MRrFOV multipleb-valueDWIscanpreoperatively.The DWIscanwasperformedusing11b-valuesof0,30,50,100,150,200,400,800,1000,1500and2000s/mm2.ADC,slowdiffusion coefficient(D),fastdiffusioncoefficient(D?)andperfusionfraction(f)weremeasuredoncancerousfociandprostatehyperplasiafoci.Allofthe datawereanalyzed.Results TheADC,D,D?andfvaluesoftheprostatecancerwere(0.61±0.12)×10-3 mm2/s,(0.41±0.08)×10-3 mm2/s, (88.0±40.3)×10-3mm2/s,289.3%±29.4%,respectively,and(09.0±01.7)×10-3mm2/s,(05.4±01.3)×10-3mm2/s,(46.1±15.3)×10-3 mm2/s, 474.3%±10.85%,respectively,forprostatehypertrophy.Thedifferencesamongthefourparameterswerestatisticallysignificant(P<0.05).The areasofADC,D,D?andfvaluesunderROCcurvestodistinguishbetweenprostatecancerandprostatehypertrophywere09.32,08.27,01.58,0.976, respectively.Conclusion 3.0T MRrFOVIVIM-DWIcanreflectthetruewaterdiffusion motionandperfusionintheprostate,and maycontributetothedifferentialdiagnosisofprostatecancerandbenignprostatehyperplasia.
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Objective To investigate the value of quantitative analysis parameters of dynamic contrast-enhanced MRI (DCE-MRI) in distinguishing low or high grade prostate cancer.Methods Data of DCE-MRI in 26 patients with prostate cancer confirmed by surgical pathology following radical prostatectomy were retrospectively analyzed.These patients were divided into low grade prostate cancer (n=10) group or high grade prostate cancer group (n=16).The parameters,including transport constant (K trans),rat constant (Kep) and extravascular extracellular volume fraction (Vc.) were measured and compared between the two groups.ROC curve was used to determine the efficacy of the parameters in distinguishing low or high grade prostate cancer.The correlation between the parameters and Gleason score were assessed.Results Ktrans,Kep and Ve values in the low grade prostate cancer group was (0.22± 0.07)/min,(1.24 ± 0.57)/min and 0.21±0.08 respectively,and (0.36±0.10)/min,(1.82±0.66)/min,0.21±0.10 respectively in the high grade prostate cancer group.The differences of K trans and Kep were statistically significant between the two groups (both P＜0.05),while of Vc.was not statistically significant (P=0.994).The area under ROC curves of K trans and keapvalues for distinguishing low or high grade prostate cancers was 0.872 and 0.737,respectively.No correlation was found between any parameters nor Gleason scores (all P＞0.05).Conclusion K trans and Kep,the quantitative analysis parameters of DCE-MRI,contribute to the differential diagnosis of low and high grade prostate cancer.
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Objective To explore the diagnostic value of MRI in female non-genital origin masses in pelvis.Methods The MRI features of female non-genital origin masses confirmed by surgery pathology in 15 patients were analyzed retrospectively.Results Preoperative MRI showed that 10 masses were mixed type,3 masses were solid,and other 2 masses were cystic,5 masess were mis-diagnosed as genital origin tumors.Pathological results revealed the masses in 6 patients from digestive system,5 from abdominal and retroperitoneal tumor,and other 4 from other tumors,including small intestine stromal tumors in 4 patients,sigmoid colon ade-nocarcinoma in 1,mucinous cystadenoma of the appendix in 1 patients,mesenteric liposarcoma in 1 schwannomas in 2,retroperitoneal fibromatosis in 1,hibernoma in 1,gossypiboma in 2,lymphatic cyst in 1,and lymphoma in 1.Conclusion Female non-genital origin masses in pelvis are easily misdiagnosed as ovarian tumor before operation,and other clinical features should be paid attention in or-der to reduce misdiagnosis.
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Objective To investigate the features and diagnostic value of MRI in prenatal and postpartum for placenta accreta. Methods 18 cases of placenta accreta confirmed by surgical pathologically and clinical were retrospectively analyzed,including 10 ca-ses of prenatal and postpartum 8 cases,observed the signal feature and diagnostic value of MRI images.Results In the 10 cases of prenatal patients with placenta accreta,MRI manifestations of 9 cases of placenta prevail,totally or partly covering cervical,10 cases of partial placenta and uterine muscle gap disappeared,boundaries are not clear,2 cases of uterine wall bars low signal-image inter-rupted,bulging outward placenta,increased sub placental vascular wag detected in 8 patients;8 cases of postpartum patients with pla-centa accrete,MRI show 4 examples which were mixed signals within the uterine cavity,with the junctional zone boundaries were not clear,the junctional zone was discontinuous interruption in 7 cases,8 cases of muscular layer appear oval,high and low,patchy mixed signals in shadow,4 cases in the palace district,5 cases of invading the shallow layer,3 cases of infection and deep muscle layers. Conclusion MRI technique is of great value for diagnosis of placenta accreta.
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PurposeTo probe into the feasibility of small field of view intravoxel incoherent motion (IVIM) MRI in the grading of cervical cancer before surgery.Materials and Methods Twenty-three patients with cervical cancer confirmed pathologically underwent preoperative conventional MRI and IVIM sequence scan [IVIM sequence included 10 b value (0-1500 s/mm2)]. Based on postoperative pathological cell morphology the patients were divided into well differentiated group (10 cases) and moderately or poorly differentiated group (13 cases). Then the parameters such as the ADC standard, D value, D* value and f value were calculated in each group according to double exponential function analysis. The data in the two groups were compared and nonparametric test to see whether they had normal distribution.Results Compared with the well differentiated group, the moderately or poorly differentiated group had statistically lower ADC standard value and D value (t=140.5 and 129.5,P0.05).Conclusion Small field of view IVIM MRI is feasible in predicting the differentiation of tumor in the preoperative grading of cervical cancer.
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Objective To discuss the clinical value of CT-guided percutaneous embedding of 125I seeds in combined chemotherapy with TP regime for non-small cell lung cancer(NSCLC). Methods Thirty two patients with NSCLC received CT-guided percutancous embedding of 125I particles, TP chemotherapy plan (paclitaxcl 135 mg/m2 /d1, cisplatin 75 mg/m2/d2 ～ 4 ) for four cycles after operation. The follow-up CT for observing therapeutic effects at 1, 3, 6, 12 month after 125I seeds implantation was undertaken. Results All cases were controlled effectively after one month revealed by CT follow up. The efficiency of tumor curing at 3, 6, 12 month were 87.5%, 90.63%, 92.31% respectively. None of the patients showed radiation injury and particle migration, and all of them had only slight side effects. Conclusion CT-guided percutaneous embedding of 125I seeds in combination with chemotherapy for non-small cell lung cancer is an effective and safe method, possessing valuable utilization clinically.