The Change of Histologic Features and Eicosanoids Level in Rat Testicular Ischemia-Reperfusion Injury / 대한비뇨기과학회지

PURPOSE: It has been suggested that prostaglandins (PGs) play an important role in ischemia-reperfusion (IR) organ injury. However, the significance of PGs is not well documented for a testicular IR injury. The purpose of this study was to assess the potential role of PGs in rat testicular ischemia and IR injury MATERIALS AND METHODS: Sprague-Dawley male rats were divided into 7 groups, each containing 7 rats. The right spermatic cord was clamped with vascular clamps for 30 minute (group B, C), 90 minute (D, E) and 240 minute (F, G). Groups B, D, and F were ischemia groups and the group C, E, and G were reperfusion groups. Reperfusion was carried out after ischemia lasting 30, 90 and 240 min. The levels of thromboxane B2 (TxB2), 6-keto-PGF1alpha and prostaglandins E2 (PGE2) were measured using High-Performance Liquid Chromatography (HPLC). RESULTS: The levels of TxB2 were significantly elevated in groups D, E, F, and G than in the controls (p<0.05, each group). The TxB2 levels in the ischemia group F were significantly decreased compared to that of group D (p<0.05). The histological features shown in groups D, and F were typical ischemic changes, but atypical in groups B, and C. The most severe damage was noted in group G. These features were well matched with the changes of TxB2 in testicular ischemia and IR injury. The levels of 6-keto-PGF1alpha were significantly elevated in all the ischemia and IR groups compared to that of the controls (p<0.05). CONCLUSIONS: These results suggested that TxB2 might have an active role in testicular IR injury, although PGE2 and 6-keto-PGF1alpha seemed not to have an active role.

Analysis of Lower Urinary Tract Injury Associated with Pelvic Fracture / 대한비뇨기과학회지

PURPOSE: The purpose of this study was to determinate a relationship of pelvic fracture, lower urinary tract injury and injury severity scale (ISS) in multiple organ injury patients. MATERIALS AND METHODS: We retrospectively reviewed the results collected from 54 cases with pelvic fracture associated with lower urinary tract injury during the period of 6 years. Emphasis was placed on the relationship of location of pelvic bone fracture, number of fractured rami, lower urinary tract injury and ISS. RESULTS: The most common cause of pelvic fracture was traffic accident giving the rate of 65.5% (38 cases). The highest score of ISS was 39.3 in pedestrian injury. Fracture of unilateral multiple rami was most common (29.3%). Among lower urinary tract injuries, urethral injury was most common giving the rate of 44.8% (26 cases). Among single urethral injuries, the type I injury was most common (50%). Suprapubic cystostomy was most common method (44.8%) in initial management. Complications of lower urinary tract injury were predominant in urethral injury and most common complication was urethral stricture (44.8%). Mortality rate was 5.2%. CONCLUSIONS: The risk of urethral injury is influenced by the number of broken pubic rami, but bladder injury by fractured bone site. ISS score was correlated with mortality rate.