ABSTRACT
Objective To explore and compare the clinical efficacy of levetiracetam tablets and compound sodium valproate sustained release tablets in the treatment of children and adolescents with epilepsy.Methods From April 2017 to April 2018,80 children and adolescents with epilepsy treated in Chaonan Minsheng Hospital of Shantou were selected as study objects,and they were randomly divided into two groups by drawing lots,with 40 cases in each group.The observation group was given levetiracetam tablets,and the control group was treated with valproate.The improvement of EEG after therapy,the total effective rate,and the incidence of adverse reactions were observed and evaluated.Results The EEG improvement rates after treatment for 6 months in the observation group and control group were 41.17％,45.71％,respectively,the difference was not statistically significant(x2 =0.508,P ＞0.05).The EEG improvement rates after treatment for 9 months in the observation group and control group were 70.58％,74.28％,respectively,the difference was not statistically significant (x2 =0.225,P ＞ 0.05).The total effective rate in the observation group was 92.50％,which was 95.00％ in the control group,the difference was not statistically significant between the two groups (x2 =0.354,P ＞ 0.05).However,the incidence rate of adverse reactions of the observation group(22.50％) was significantly lower than that of the control group(45.00％)(x2 =6.864,P ＜ 0.05).Conclusion Both levetiracetam tablets and compound sodium valproate sustained release tablets have appreciable efficacy and safety in the treatment of epilepsy in children and adolescents,but levetiracetam therapy has less adverse reactions,which deserves further promotion in monotherapy of epilepsy in children and adolescents.
ABSTRACT
Objective To investigate the treatment effect of amlodipine atorvastatin calcium for hypertensive patients with dyslipidemia.Methods The clinical data of 200 hypertensive patients with dyslipidemia were retrospectively studied.They were divided into the control group and the intervention group according to treatment method,100 cases in each group.The control group was given amlodipine besylate based on the conventional treatment,the intervention group was treated with amlodipine besylate and atorvastatin calcium tablets.The clinical effect was observed and compared between the two groups.Results After treatment,the systolic and diastolic blood pressure of the two groups were significantly lower than before treatment (t =4.57,5.32,4.72,4.61,all P ＜ 0.05) ; After treatment,IMT and plaque area of the two groups were obviously lower than before treatment(t =3.16,3.43,all P ＜ 0.05) ;After treatment,IMT and plaque area of the intervention group were (0.71 ± 0.29) mm and (1 t.13 ± 3.61) mm2,which were significantly lower than those of the control group [(0.82 ± 0.26) mm and (13.64 ± 2.86) mm2] (t =3.28,4.05,all P ＜ 0.05).Conclusion Amlodipine besylate and atorvastatin calcium tablets can effectively reduce hypertension,which has good synergistic effect and protective effect on blood vessels.
ABSTRACT
Objective To evaluate the imaging features of acute necrotizing encephalopathy caused by children A H1N1 influenza.Methods CT and MRI brain imaging data of three children acute necrotizing encephalopathy caused by A H1N1 influenza virus and proved by clinical and laboratory investigation were analyzed.All the three children got CT and MRI scan because of coma while in hospital.Results All cases represented multifocal damage,and some were symmetrical.Bilateral thalamencephalons were involved in the all cases.Bilateral grey and white matters of frontal lobe,temporal lobe,parietal lobe and occipital lobe,and hippocampi,putamina,external capsule,brain stem,bilateral cerebellum,could be seen multifocal damage,and some were symmetrical.All the cases showed brain swelling in varying degrees.These region presented low density in CT,hypointensity on T1 weighted series and hyperintensity on T2 weighted series and FLAIR series in MRI.Conclusion The imaging features of acute necrotizing encephalopathy caused by children A H1N1 influenza represented multifocal and symmetrical damage and brain swelling.It may be characteristic that bilateral thalamencephaloas were involved.The patient was serious,and fatality rate was high.So we should pay much attention to acute necrotizing encephalopathy caused by children A H1 N1 influenza.